DYRK1A Signaling in the Brain: Molecular Mechanisms and Neurotransmitter Regulation [0.03%]
脑中的DYRK1A信号传导：分子机制和神经递质调节
Sampriti Paul,Sonal Dubey,Prashant Tiwari
Sampriti Paul
Introduction: DYRK1A (dual-specificity tyrosine phosphorylation-regulated kinase 1A) is a dosage-sensitive regulator of central nervous system development. Dysregulation contributes to major neurodevelopmental disorders, ...
Early Arthritis Detection Using Convolutional Neural Networks for Enhanced Diagnostic Accuracy [0.03%]
基于卷积神经网络的早期关节炎检测以提高诊断准确性
Kamini Solanki,Arpitkumar Shah,Arpankumar Raval et al.
Kamini Solanki et al.
Introduction/objective: Arthritis is a widespread musculoskeletal disease, which is characterized by inflammation, pain, stiffness, and progressive loss of joint mobility and has a significant impact on quality of life ac...
Neuroprotection Through Nature: The Role of Bioactive Phytocompounds in Alzheimer's and Parkinson's Disease [0.03%]
源于自然的神经保护作用：植物活性成分在阿尔茨海默病和帕金森病中的作用
Namra Aziz,Pranay Wal,Gagandeep Singh Basra et al.
Namra Aziz et al.
Introduction: Neurodegenerative diseases, notably Alzheimer's Disease (AD) and Parkinson's Disease (PD), represent a significant and growing global health burden, characterized by progressive cognitive and motor dysfuncti...
In Silico Prediction, Characterization, and Pre-clinical Appraisal of the Neuroprotective Effect of the Methanolic Extract of Cassytha filiformis [0.03%]
基于计算机的预测、鉴别及药理评价：Cassytha filiformis甲醇提取物具有神经保护作用
Nithya R,Sonal Dubey,Dileep Kumar et al.
Nithya R et al.
Introduction: Alzheimer's disease (AD) is a severe neurodegenerative disorder that progressively worsens with age. Medicinal plants have demonstrated potential for the management of AD. Cassytha filiformis, a native plant...
Retrospective External Validation of the ELAPSS Score for the Prediction of Unruptured Intracranial Aneurysm Growth Risk [0.03%]
ELAPSS评分预测颅内未破裂动脉瘤风险的外部验证研究
Sun Yoon,Chang Ki Jang,Nak-Hoon Son et al.
Sun Yoon et al.
Introduction: This study aimed to evaluate the accuracy of the Earlier Subarachnoid Hemorrhage, Aneurysm Location, Age, Population, Aneurysm Size, And Shape (ELAPSS) score in predicting the growth risk of unruptured intra...
Therapeutic Potential of Natural Chalcones Against Alzheimer's Disease: A Mechanistic Insight [0.03%]
天然查尔酮治疗阿尔茨海默病的潜力：机制见解
Sweta Sinha,Sandeep Gupta,Prashant Tiwari
Sweta Sinha
Introduction: Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive deficits, amyloid-beta (Aβ) plaque deposition, tau hyperphosphorylation, oxidative stress, and chronic neuroin...
Therapeutic Potential of a Phytochemical-rich Herbal Formulation (Ezenus) in the Modulation of Stress and Anxiety-related Behaviors: Evidence from Preclinical Models [0.03%]
一种富含植物化学物质的草药配方（Ezenus）在调节应激和焦虑相关行为方面的治疗潜力：来自临床前模型的证据
Samaresh Pal Roy,Dhaval M Patel,Suchismita Bhowmik et al.
Samaresh Pal Roy et al.
Background: Chronic stress and anxiety have been linked to detrimental physiological impacts that can diminish quality of life. Herbal formulations are being progressively investigated as alternative therapies. This study...
Ferroptosis Transferrin Receptor Protein 1 (TFRC) Improves the Functional Prognosis After Ischemic Stroke by Regulating Gut Microbiota: A Mendelian Randomization and Mediation Analysis [0.03%]
转铁蛋白受体蛋白1（TFRC）通过调节肠道微生物群改善缺血性卒中的功能预后：孟德尔随机化和中介分析
Chunshu Rong,Zhen Wei,Xue Wang et al.
Chunshu Rong et al.
Introduction: Recent research indicates that ferroptosis plays a role in Ischemic Stroke (IS). This study aims to investigate the causal connections and underlying mechanisms involving Ferroptosis-related genes, Gut Micro...
The Relationship between Traumatic Brain Injury and Systemic Health: Dissecting the Somatic and Neurological Effects [0.03%]
创伤性脑损伤与全身健康之间的关系：解剖其躯体和神经效应
Sachin Gulia,Megha Thakur,Vipin Kumar et al.
Sachin Gulia et al.
Introduction: Traumatic brain injury (TBI) is a neurological disorder caused by external biomechanical forces such as sports impacts and vehicular accidents. It is a leading cause of morbidity and long-term disability acr...
Evaluating the Causal Relationship between Personality and Parkinson's Disease [0.03%]
人格和帕金森病之间因果关系的评估
Fuquan Zhang,Ning Zhou,Hongbao Cao et al.
Fuquan Zhang et al.
Introduction: Understanding personality is crucial for monitoring progression and evaluating treatments for Parkinson's disease (PD). However, the causal relationships between personality and PD have yet to be elucidated....