Melatonin Inhibits the Malignant Progression of Glioblastoma via Regulating miR-16-5p/PIM1 [0.03%]
褪黑素通过调节miR-16-5p/PIM1抑制胶质母细胞瘤恶性进展
Zhaoxian Yan,Xin Zhang,Lin Hua et al.
Zhaoxian Yan et al.
Objectives: Melatonin (MT) is a pineal hormone with antineoplastic potential. This study aims to explore the therapeutic potential and mechanism of MT on glioblastoma (GBM). ...
Downregulation of CHCHD2 may Contribute to Parkinson's Disease by Reducing Expression of NFE2L2 and RQCD1 [0.03%]
CHCHD2表达下调通过降低NFE2L2和RQPQ1的表达可能参与帕金森病的发生发展
Kelu Li,Pingping Ning,Bin Liu et al.
Kelu Li et al.
Background: Parkinson's disease (PD) is associated with coiled-coil-helix-coiled-coilhelix domain containing 2 (CHCHD2) downregulation, which has been linked to reduced cyclocytase activity and increased levels of oxygen ...
Association Between Systemic Immune-Inflammation Index and Symptomatic Intracranial Hemorrhage in Acute Ischemic Stroke Patients Undergoing Endovascular Treatment [0.03%]
急性缺血性卒中患者血管内治疗的症状性颅内出血与全身免疫炎症指数的关系
Yuan Yang,Ting Cui,Xueling Bai et al.
Yuan Yang et al.
Background/objective: Systemic immune-inflammation index (SII) is a novel inflammatory factor, which may be involved in the destruction of the blood-brain barrier (BBB) after acute ischemic stroke (AIS); however, the asso...
Keap1 as Target of Genistein on Nrf2 Signaling Pathway Antagonizing Aβ induced Oxidative Damage of Cerebrovascular Endothelial Cells [0.03%]
染料木素靶向Keap1对抗Aβ诱导的脑血管内皮细胞氧化损伤及其对Nrf2信号通路的影响研究
Yuan-Di Xi,Xiao-Ying Li,Ya-Fei Chi et al.
Yuan-Di Xi et al.
Background: β-amyloid peptides (Aβ) induced oxidative damage contributes to the pathogenesis of neurodegenerative diseases, and the cerebrovascular system is more vulnerable to oxidative stress. Our earlier study showed...
Analysis of Prognostic Risk Factors for Ischemic Stroke in China: A Multicentre Retrospective Clinical Study; A National Survey in China [0.03%]
中国缺血性卒中预后影响因素分析及全国多中心横断面调查研究
Yuting Cao,Ying Chen,Xiaoli Zhang et al.
Yuting Cao et al.
Background: Stroke is a serious disease that threatens human health both in China and worldwide. Identifying and establishing its risk factors are prerequisites for intervention and evaluation of prognosis. Over the years...
Multicenter Study
Current neurovascular research. 2022;19(1):117-126. DOI:10.2174/1567202619666220331160024 2022
Cerebral Ischemia Induces Iron Deposit, Ferritin Accumulation, Nuclear Receptor Coactivator 4-depletion, and Ferroptosis [0.03%]
脑缺血诱导铁沉积、铁蛋白蓄积、辅激活因子4耗竭和铁死亡发生
Nora Hanke,Abdelhaq Rami
Nora Hanke
Background: The neuronal death upon cerebral ischemia shares not only characteristics of necrosis, apoptosis, and autophagy but also exhibits biochemical and morphological characteristics of ferroptosis. Ferroptosis is a ...
The Angiogenesis Effects of Electro-acupuncture Treatment via Exosomal miR-210 in Cerebral Ischemia-Reperfusion Rats [0.03%]
电针通过释放外泌体miR-210促进缺血再灌注大鼠脑内新生血管效应
Shu-Ying Xu,Chun-Li Zeng,Si-Ming Ni et al.
Shu-Ying Xu et al.
Background: Acupuncture has been recommended as an alternative and complementary therapy for preventing and treating cerebral ischemia by the World Health Organization (WHO) for years. However, the mechanisms remain uncle...
MicroRNA-17-5p Promotes Vascular Calcification by Targeting ANKH [0.03%]
microRNA-17-5p通过靶向ANKH促进血管钙化
Chao Shi,Jiaorong Tan,Jiancan Lu et al.
Chao Shi et al.
Background: MicroRNAs (miRNAs) may participate in the process of vascular calcification. However, the role of microRNA-17-5p in vascular calcification has not been clarified. In this study, we showed the effects of microR...
Propofol Rescued Astrocytes from LPS-induced Inflammatory Response via Blocking LncRNA-MEG3/NF-κB Axis [0.03%]
异丙酚通过抑制长链非编码RNA-MEG3/核因子-κB轴缓解LPS诱导的星形胶质细胞炎症反应
Fan Zhang,Zhihua Wang,Bei Sun et al.
Fan Zhang et al.
Objective: Evidences demonstrate that propofol attenuates neuro-inflammation following brain ischemia. Moreover, LncRNA-MEG3 has been identified as an independent prognostic marker for ischemic stroke patients, and found ...
Correlation Between Plasma Levels of RIP3 and Acute Ischemic Stroke with Large-Artery Atherosclerosis [0.03%]
RIP3蛋白血浆水平与大动脉粥样硬化性急性缺血性卒中的相关性研究
Beilei Chen,Jing Hang,Yuanyuan Zhao et al.
Beilei Chen et al.
Background: Receptor-interacting serine-threonine protein kinase 3 (RIP3) was previously discovered to be an important medium in the occurrence and development of major atherosclerotic cerebral infarction. However, the ro...