Shristi Singh,Ajita Paliwal,Niranjan Kaushik et al.
Shristi Singh et al.
Protein kinase inhibitors (PKIs) are medicinal substances that target enzymes essential to vital cellular functions by controlling kinase activity. PKIs are being considered as targeted therapeutics to disrupt carcinogenic pathways since dy...
Profilin and Its Isoforms: Unravelling the Functional Diversity Across Life Forms [0.03%]
profilin及其异构体：揭示生命形式的功能多样性
Nupur Pathak,V Kohila
Nupur Pathak
The dynamic nature of the cell wall or plasma membrane is extremely important for the various cellular functions. The rearrangement of the cytoskeleton within the cell is a crucial process that is coordinated by the Profilin (PFN) protein. ...
Benzimidazole Derivatives in Alzheimer's Therapy: Exploring Multi-Target Pathways [0.03%]
苯并咪唑衍生物在阿尔茨海默病治疗中的多靶点作用机制研究
Shantanu Gavade,Sonal Dubey,Prashant Tiwari
Shantanu Gavade
Alzheimer's disease (AD) is a leading cause of dementia worldwide and continues to be one of the most frequently diagnosed neurodegenerative disorders in adults aged 65 and older. While much progress has been made in exploring AD pathophysi...
Enzymatic Synthesis of β-lactam Antibiotics: From Enzyme Dataset Construction to Action Mechanism and Semi-Rational Design [0.03%]
β-内酰胺抗生素的酶法合成：从酶数据集构建到作用机制及半理性设计研究
Wenqin Luo,Kaixuan Hu,Wentong Yu et al.
Wenqin Luo et al.
β-lactam Antibiotics (BLA) are characterized by the presence of lactam rings, which are widely used and have a huge market scale. Currently, the production of BLA is primarily achieved through a chemical process, which introduces a large n...
MmpS5-MmpL5 Transporters Deliver M. tuberculosis Resistance to Bedaquiline (BDQ) and Delamanid (DLM) [0.03%]
MmpS5-MmpL5转运蛋白赋予结核分枝杆菌贝达喹啉和德拉马尼抗性的机制研究
Khaoula Balgouthi,Emel Eker,Manaf AlMatar
Khaoula Balgouthi
Introduction: One of the earliest illnesses that has been identified is tuberculosis (TB). The largest challenge in managing tuberculosis today is the growing number of individuals infected with TB bacilli, particularly t...
Evaluation of FOXP3 Exons 2 and 7 Variants in Recurrent Pregnancy Loss among South Indian Women [0.03%]
评估FOXP3外显子2和7变异在南印度妇女反复自然流产中的作用
Sufaya Jameel,Sourish Sen,Rashmi Bhuwalka et al.
Sufaya Jameel et al.
Introduction: One to two percent of women worldwide experience recurrent pregnancy loss (RPL), defined as the loss of two or more consecutive pregnancies before 20 weeks of gestation. Genetic factors, including variations...
The Emergence of Bioactive Peptides as Anti-diabetic Agents: A Review [0.03%]
生物活性肽作为抗糖尿病制剂的研究进展：一篇综述
Ramanand -,Rohit Singh,Vedpal Singh et al.
Ramanand - et al.
A complex condition called diabetes mellitus is characterized by insufficient or resistant insulin production. The incidence of diseases is rising quickly, placing a significant economic, social, and health burden on the modern world. Inter...
The Role of Various Autoantibodies and Alpha2-Macroglobulin in Patients with Hashimoto Disease: Does the Presence of Elevated Antibodies Correlate with Alpha 2-Macroglobulin Levels in Hashimoto Disease? [0.03%]
桥本病患者各种自身抗体和α2巨球蛋白的作用：桥本病中 elevated 抗体的存在是否与 α 2 巨球蛋白水平相关？
Rena Rahimova,Gulnara Azizova,Ilaha Shahverdiyeva et al.
Rena Rahimova et al.
Introduction: Autoimmune Thyroiditis (AIT) is caused by defects in the immune system in people with a genetic predisposition to the disease. The most prevalent type of autoimmune thyroiditis is Hashimoto's thyroiditis (HT...
Comprehensive Analysis of Glycosyltransferase-Related Genes Reveals their Prognostic and Therapeutic Implications in Stomach Adenocarcinoma [0.03%]
糖基转移酶相关基因的全面分析及其在胃腺癌预后和治疗中的作用
Guizhen Lyu,Dongbing Li
Guizhen Lyu
Introduction: This study aimed to investigate the role of glycosyltransferase-related genes (GRGs) in stomach adenocarcinoma (STAD) through bioinformatic analysis and experimental validation, exploring their potential as ...
An In-Depth Study of Circular RNAs Related to Breast Cancer Treatment and their Implications [0.03%]
与乳腺癌治疗相关的环形RNA的深入研究及其意义
Fatima Akram,Zoha Naeem Rana,Ifrah Shabbir et al.
Fatima Akram et al.
Circular RNAs, or circRNAs, play a key role in breast cancer biology, directly impacting the diagnosis, prognosis, and treatment of the disease. This review explores the mechanisms, regulatory roles, and functional significance of circRNAs ...