Glucagon-like Peptide-1 Boosts Plumbagin's Neuroprotection Against Rotenone-Induced Motor Deficits [0.03%]
胰高血糖素样肽-1增强泽泻烯对罗tenone诱导的运动障碍的神经保护作用
Aanchal Verma,Ahsas Goyal
Aanchal Verma
Introduction: Parkinson's disease (PD), a condition that involves neural degeneration, develops due to dopaminergic neuronal death in the substantia nigra pars compacta, resulting in reduced striatal dopamine levels. This...
Therapeutic Horizons for Parkinson's Disease: Current Relevance of PNA5 in Memory and Cognition [0.03%]
帕金森病的治疗前景：PNA5目前在记忆和认知中的相关性
Kousik Maparu,Dhrita Chatterjee,Nileshwar Kalia et al.
Kousik Maparu et al.
Parkinson's disease (PD) is a neurodegenerative disorder characterized primarily by the progressive loss of dopaminergic neurons in the substantia nigra and the pathological aggregation of α-synuclein. While some genetic and environmental ...
Solid-Phase Synthesized Imunofan Confers Clinically Relevant Protection using a Chimeric Protein Vaccine Candidate Against E. coli O157:H7 in BALB/c Mice [0.03%]
固相合成免疫原利用嵌合蛋白候选疫苗对BALB/c小鼠预防大肠杆菌O157:H7感染提供临床相关保护作用
Ali Mozaffari Mansourabad,Hossein Samiei-Abianeh,Yousof Tarverdizadeh et al.
Ali Mozaffari Mansourabad et al.
Introduction/Objective: This study aimed to evaluate the efficacy of Imunofan, a synthetic peptide adjuvant, compared to Freund's adjuvant. We hypothesized that imunofan would enhance protective immunity while avoiding the adverse effects a...
Enzymatic Characterization of Alkaline Protease from a Novel Microorganism Isolated from a Halophilic Environment [0.03%]
从盐化环境中分离的一株新菌株中碱性蛋白酶的酶学性质研究
R P Rejisha,M Murugan
R P Rejisha
Introduction: Microbial enzymes, especially bacterial alkaline proteases, are essential to many industrial processes, including the manufacturing of detergents, food processing, bioremediation, medicines, and tanneries. Because of its possi...
Uma Agarwal,Garima Kapoor,Rajiv Kumar Tonk
Uma Agarwal
Introduction: Alzheimer's disease is characterized by a complex and multifactorial pathogenesis, involving key features such as amyloid-beta plaques, tau tangles, and neuron loss. Understanding the disease requires invest...
Versatility of Collagen as a Natural Biopolymer for Biomedical, Food, and Cosmetic Applications [0.03%]
胶原蛋白作为生物医学、食品和化妆品应用的天然生物聚合物的多功能性
Avijit Kumar Dey,Soumya Pal,Sonjit Das et al.
Avijit Kumar Dey et al.
Collagen is the most abundant structural protein and an essential connective tissue constituent. It plays vital roles in the body and is found in different tissues, including tendons, cartilage, bones, and skin. Collagen is mainly extracted...
RGD Peptide-Based Hydrogel Enhances the Osteogenic Differentiation of Periodontal Ligament Stem Cells via Wnt Signaling [0.03%]
基于RGD肽的水凝胶通过Wnt信号促进牙周韧带干细胞成骨分化
Nadia Naeem,Muhammad Atif Siddiqui,Nazia Ahmed et al.
Nadia Naeem et al.
Introduction: Periodontitis results in progressive loss of gingival tissue and periodontal ligament, eventually resulting in tooth instability. As regenerating degraded periodontal tissue is not possible without intervent...
Artificial Intelligence in Proteins and Peptides: A Comprehensive Overview from Hybrid Modeling to Deep Learning [0.03%]
人工智能在蛋白质和肽中的应用：从混合建模到深度学习的全面概述
Yindan Luo,Jiaxin Cai,Xiaohua Niu
Yindan Luo
In-silico and In-vivo Investigations Reveal Ameliorative Potential of Myricetin Against Doxorubicin-induced Myocardial Damage via Modulation of NF-κB Signaling Pathway [0.03%]
基于Myricetin的多酚类化合物通过调节NF-κB信号途径对阿霉素诱导的心肌损伤具有改善潜力：从计算机模拟到体内实验研究
Purvaj G Barote,Harshal D Pawar,Mudassar Sayyed et al.
Purvaj G Barote et al.
Introduction: Although Doxorubicin (DOX) is an effective anticancer agent, its cardiotoxicity limits clinical use. DOX-induced oxidative stress augments NF-κB expression, elevates inflammatory cytokines, and causes myoca...
From CASP13 to the Nobel Prize: DeepMind's AlphaFold Journey in Revolutionizing Protein Structure Prediction and Beyond [0.03%]
从CASP13到诺贝尔奖：AlphaFold的aI蛋白质结构预测之旅及未来发展展望
Jad Abbass
Jad Abbass
Four years ago, at the 14th Critical Assessment of Structure Prediction (CASP14), John Moult made a historic announcement that the long-standing challenge of Protein Structure Prediction- a problem that had confounded scientists for over fi...