TEAD4 Identified as a Potential Biomarker for Gastric Cancer Via Genes Associated with Liquid-Liquid Phase Separation [0.03%]
通过与液-液相分离相关基因鉴定TEAD4为胃癌潜在生物标志物
Jianzhong Liu,Jingwen Zhang,Aixia Gong
Jianzhong Liu
Introduction: Liquid-liquid phase separation (LLPS) has emerged as a critical mechanism in tumor progression, and its relevance to gastric cancer (GC) is increasingly recognized. However, the mechanisms linking LLPS to GC...
2026: The Year of Innovation, Sustainability, and Education in Protein and Peptide Science [0.03%]
2026：蛋白质和肽科学的创新、可持续性和教育之年
Anna Maria Papini
Anna Maria Papini
Protocatechuic Acid Alleviates Neurodemyelination by Modulating PKCα-p38/MAPK Pathways in an LPC-Induced Model of Neurodegeneration [0.03%]
没食子酸通过调节PKCα-p38/MAPK信号途径缓解溶血磷脂诱导的神经退行性病变中的轴突脱髓鞘病理损伤
Sonia Siddiqui,Priya Tufail,Faisal Khan et al.
Sonia Siddiqui et al.
Introduction: Neuroinflammation, axonal damage, and alterations in extracellular matrix (ECM) protein expression are hallmarks of neurodegenerative diseases. Therapies that enhance recovery from brain injury are of signif...
The Role of Mitochondrial Ion Channels in the Evolution of Anticancer Drug Resistance [0.03%]
线粒体离子通道在抗癌症药物耐药性进化中的作用
Swaroop Kumar Pandey,Ayush Kulshreshtha,Anuja Mishra
Swaroop Kumar Pandey
Apoptosis, drug resistance, and cellular metabolism are all crucially regulated by mitochondria, especially through ion channels and translocases embedded in their membranes. The outer mitochondrial membrane (OMM) contains the voltage depen...
Multi-omics Analysis Reveals the Role of lncRNAs and Peptides in the Age-related Hearing Loss [0.03%]
多组学分析揭示长链非编码RNA和肽在年龄相关性听力损失中的作用
Cong Li,Danyang Liu,Kunyan He et al.
Cong Li et al.
Introduction: The pathogenesis of age-related hearing loss (ARHL), especially the role of long non-coding RNAs (lncRNAs) and their encoded peptides, remains incompletely understood. This study aimed to characterize expres...
Research Progress on the Intervention of Traditional Chinese Medicine Monomers on Signaling Pathways Related to Sarcopenia and Osteoporosis [0.03%]
中医药单体干预防治骨骼肌衰减和骨质疏松症相关信号通路的研究进展
Zhuo-Xu Gu,Xian-Quan Zhang,Guang-Hui Zhou et al.
Zhuo-Xu Gu et al.
Sarcopenia and osteoporosis are conditions characterized by the synergistic effects of sarcopenia and osteoporosis, leading to the loss of muscle mass, muscle strength, bone density, and bone quality. This condition is marked by a high disa...
Bhawna Sharma,Iti Chauhan,Rohit Pandey et al.
Bhawna Sharma et al.
Plant-based proteins are receiving increasing attention as sustainable and healthconscious alternatives to animal-derived proteins, addressing both environmental concerns and growing consumer demand. This review explores key plant protein s...
Intricacies of PKB/Akt Activity after Sciatic Nerve Damage: A Comprehensive Review [0.03%]
胫神经损伤后PKB/Akt活性的复杂性：全面综述
Rajesh Dabur
Rajesh Dabur
Sciatic nerve injury represents a prevalent and incapacitating condition characterized by denervation, muscular atrophy, and compromised functionality. The Protein Kinase B (PKB)/ Akt signaling cascade serves as a vital modulator of skeleta...
Molecular Signaling and Biased Agonism of the CHEMR23 Receptor: Implications for Inflammation Resolution and Bone Remodeling [0.03%]
CHEMR23受体的分子信号传导和偏向性激动作用：对炎症消退和骨重建的意义
Olga A Neprelyuk,Inessa G Romanenko,Oksana L Irza et al.
Olga A Neprelyuk et al.
The chemerin chemokine-like receptor 1 (CHEMR23), a member of the G proteincoupled receptor (GPCR) family, has emerged as a key regulator of immune homeostasis and skeletal remodeling. Notably, CHEMR23 exhibits ligand-specific biased agonis...
Advances in the Role of FOXM1 and Ferroptosis in the Diagnosis, Treatment, and Prognosis of Hepatocellular Carcinoma [0.03%]
FOXM1和铁死亡在肝细胞癌诊断、治疗及预后中的作用进展
Xin Li,Ruonan Zhang,Xiaoyue Zhao et al.
Xin Li et al.
Hepatocellular carcinoma (HCC) is a highly lethal cancer with a poor prognosis due to difficulties in early diagnosis. In recent years, the roles of FOXM1 and ferroptosis in HCC have attracted attention. FOXM1, a key transcription factor hi...