Advances in the Study of Noncoding RNAs in the Pathogenesis of Pregnancy-related Diseases [0.03%]
非编码RNA在妊娠相关疾病发病机制研究中的进展
Kunzheng Fan,Qingqing Xu,Wenjing Liang et al.
Kunzheng Fan et al.
Noncoding RNAs (ncRNAs) are a heterogeneous group of RNA molecules that lack protein-coding capability. The major classes of ncRNAs are long noncoding RNAs (lncRNAs), microRNAs (miRNAs), and circular RNAs (circRNAs). Numerous studies have c...
Bioactive Antioxidant Peptides as Novel Natural Interventions for Cardiometabolic Disorders: Mechanistic Insights and Phytotherapeutic Potential [0.03%]
具有抗氧化活性的肽作为心血管代偿失调的新天然干预机制及植物医药潜力
Prashant Mishra,M Salman Khan
Prashant Mishra
Cardiometabolic disorders (CMDs) represent a significant health challenge worldwide, and they consist of a vast range of cardiovascular and metabolic disorders such as dyslipidemia, hypertension, atherosclerosis, obesity, type 2 diabetes, a...
Edible Insects and the Brain: Historical Human Use and the Potential Benefits of Bioactive Peptides [0.03%]
可食用昆虫与大脑：人类历史使用及生物活性肽的潜在益处
Joyce Hellyen Santos Pereira,Bruna Kaicy Barbosa,Sérgio Henrique Santos
Joyce Hellyen Santos Pereira
Entomophagy is an ancient human strategy for obtaining nutritional value and treating diseases. In recent years, the importance of incorporating insects into the diet has increased as new studies demonstrate their numerous health benefits. ...
Marine-Derived Quinolinone CHNQD-00603 Triggers Autophagy via Suppressing the AKT/ERK/mTOR Pathway to Reverse Senescence and Restore Osteogenic Potential in Bone Marrow Mesenchymal Stem Cells [0.03%]
海洋来源的喹啉酮CHNQD-00603通过抑制AKT/ERK/mTOR信号通路诱导自噬以逆转衰老并恢复骨髓间充质干细胞成骨分化潜能
Shengqian Li,Baoying Peng,Xiaoxia Yang et al.
Shengqian Li et al.
Introduction: Cellular senescence of Bone Marrow Mesenchymal Stem Cells (BMSCs) acts as a primary driver of age-related bone loss. This study aimed to investigate the anti-senescence potential of CHNQD-00603, a marine-der...
Valorization of Keratin-Rich Waste: Extraction, Characterization, and Biomedical Applications [0.03%]
角蛋白废料的高值化利用：提取、表征及生物医药应用
Sourav Mandal,Kamalakanta Ray,Indranil Chatterjee et al.
Sourav Mandal et al.
Keratin is a fibrous structural protein that occurs in abundance in hair, wool, feathers, horns, and nails, and it is a valuable biopolymer with great biomedical applications. The poultry, textile, and leather industries produce millions of...
Optimization, Expression, Purification, and Activity Identification of Anti-PD-1 scFv [0.03%]
抗PD-1 scFv的优化、表达、纯化及活性鉴定
Wan Jiandong,Yu Peining,Liu Yulin et al.
Wan Jiandong et al.
Introduction: Anti-PD-1 monoclonal antibodies have revolutionized cancer therapy but face challenges, including immune-related adverse events, poor tumor penetration due to their large size, and high production costs. Sin...
In Vitro Synergistic Inhibition and Eradication of Pathogenic Bacterial Biofilms by Bacillus subtilis-derived Anti-biofilm Enzymes [0.03%]
枯草芽孢杆菌抗生物被膜酶体外协同抑制和消解病原菌生物被膜的作用研究
Ayisha Aman Ullah,Mawa Naeem,Fiza Khan et al.
Ayisha Aman Ullah et al.
Introduction: Biofilm formation is a crucial virulent attribute of pathogens that promotes their resistance to antibiotics and contributes to chronic illnesses in humans. Traditional antibiotic therapies have proven ineff...
Antimicrobial Peptides: Structure, Mechanisms, and Therapeutic Potential in Combating Infectious Diseases [0.03%]
抗菌肽：结构、机制及其在对抗传染病方面的治疗潜力
Shivendra Verma,Ranu Singh,Manoj Kumawat
Shivendra Verma
Antimicrobial peptides (AMPs) are small, naturally occurring molecules that play a key role in the immune defense of multicellular organisms. They show strong and broad activity against many harmful agents, including bacteria, viruses, fung...
Exploring Synergistic Anti-Psoriatic Potential of Bioactive Compounds Tyrosol and Farnesol through In-Silico and In Vitro Approaches [0.03%]
基于 silico 和 in vitro 方法探索生物活性化合物酪醇和法尼醇的抗银屑病协同潜力
Pankaj Singh Patel,Rajnish Srivastava,Naveen Singh et al.
Pankaj Singh Patel et al.
Introduction: Psoriasis is a chronic inflammatory skin disease affected by genetic, immune, and environmental factors. The purpose of the study was to examine the anti-psoriatic properties of Tyrosol and Farnesol against ...
Lipidation & Stapled Peptides: Enhancing Stability and Pharmacokinetics [0.03%]
脂化及环肽技术：提高稳定性和药代动力学性质
R P Rajesh,Masilamani Selvam,Srinivasan Palaniselvam et al.
R P Rajesh et al.
The potential of peptide therapeutics is high because the targeting is highly specific, toxicity is low, and also the ability to affect complex biological determinants. These things are, however, hampered by issues like low stability, faste...