Determinants of Epitope Immunodominance Hierarchies in Protein Antigens at the Molecular, Structural, and Cellular Levels, Including MHC-Dependent Mechanisms [0.03%]
蛋白质抗原位点的分子、结构和细胞水平上决定表位免疫优势层次的因素，包括MHC依赖机制的影响
David Pedroza-Escobar,Tania González-Cortés,Irais Castillo-Maldonado et al.
David Pedroza-Escobar et al.
Background: Epitope immunodominance describes the phenomenon whereby some antigenic epitopes preferentially elicit immune responses, whereas other epitopes remain subdominant or immunologically silent. Epitope immunodomin...
The Role of Antimicrobial Peptide (AMP) Delivery Systems in Combating Antimicrobial Resistance: Current Trends and Novel Approaches [0.03%]
抗菌肽(AMP)递送系统在对抗抗生素耐药性方面的应用：当前趋势和新颖方法
Anshu,Atul Pratap Singh,Himanchal Sharma et al.
Anshu et al.
The rise of antimicrobial resistance (AMR) has emerged as a critical global health concern, undermining the effectiveness of conventional antibiotics and complicating the treatment of infectious diseases. As a result, there is an urgent nee...
Critical Role of Calcitonin Gene-related Peptide (CGRP) in the Microbiome-gut-brain Axis [0.03%]
降钙素基因相关肽(CGRP)在微生态-肠-脑轴的关键作用
Wen-Juan Qiu,Yan Chen,Shen-Yi Ye et al.
Wen-Juan Qiu et al.
Calcitonin gene-related peptide (CGRP), a neuropeptide with α and β isoforms, is a pivotal regulator connecting the neural, immune, and gastrointestinal systems. This comprehensive analysis delineates the evidence-based mechanistic roles ...
Radiolabeled-NeoB: A Dual-Action Diagnostic and Therapeutic Agent Targeting Gastrin-Releasing Peptide Receptors in Cancer [0.03%]
放射性标记的NeoB：一种针对癌症胃泌素释放肽受体的双重作用诊断和治疗剂
Hiva Rahmati,Seyed Mehdi Mousavi,Fatemeh Jalali-Zefrei et al.
Hiva Rahmati et al.
Nuclear medicine has revolutionized diagnostic and therapeutic strategies in oncology by offering molecular-level insights into tissue function-often detecting pathological changes before they manifest structurally. At the heart of this adv...
Advancing Diabetic Wound Care: Topical Transferosomal Insulin Delivery for Improved Healing [0.03%]
糖尿病伤口护理的进展：外用转移体胰岛素递送促进伤口愈合
Arpita Bhakuni,Lalit Singh,Monika Gulia et al.
Arpita Bhakuni et al.
Background: Diabetes, a chronic metabolic disorder, is associated with severe health complications, including impaired wound healing, affecting approximately 25% of diabetic individuals worldwide. Factors such as neuropat...
Biomarker Revolution in Choriocarcinoma: Beyond β-hCG - Emerging Tools for Diagnosis, Prognosis & Therapeutic Monitoring [0.03%]
胎盘滋养细胞肿瘤生物标记革命：超越β-HCG——用于诊断、预后和监测治疗的新兴工具
Mishu Mangla,Seetu Palo,Aparna Setty et al.
Mishu Mangla et al.
Choriocarcinoma, a rare yet highly aggressive gestational trophoblastic neoplasia, is uniquely responsive to chemotherapy. The serum marker β-human chorionic gonadotropin (βhCG) has long been central to its diagnosis and monitoring, but n...
1 H NMR-Based Metabolomics Survey in Breast Cancer Cell Line Treated by Chimera Alpha - Fetoprotein (AFP) Peptide [0.03%]
基于1H核磁共振代谢组学的 chimera AFP 肽处理乳腺癌细胞系的谱效关系研究
Seyedeh Masoumeh Nourolahi,Mahdi Behdani,Monireh Movahedi et al.
Seyedeh Masoumeh Nourolahi et al.
Introduction: This study investigates the anticancer potential of the synthetic 15-mer HM-I peptide (SMAIRVSISERSLYI), derived from a chimeric rat/human α-fetoprotein (AFP). HM-I is proposed as a selective anti-cancer ag...
Recent Advances in Antimicrobial Proteins and Peptides: A Promising Clinical Breakthrough and Patent Landscape [0.03%]
近年抗菌蛋白质和肽的研究进展：颇具临床突破及专利价值的新兴领域
Sakshi Patel,Sanjay Sharma,Abhishek Kanugo
Sakshi Patel
Antimicrobial resistance (AMR, when microbes stop responding to medicines) is a growing worldwide concern calling for novel alternatives to conventional antibiotics. Because of their wide range of efficacy, ability to support the body's nat...
Nanoparticle-Driven Advances in Antimicrobial Therapy: Strengthening Peptide Effectiveness [0.03%]
纳米粒子驱动的抗菌疗法进展：增强肽类药效
Lalit Kumar,Vikas Aggarwal,Vishnu Das et al.
Lalit Kumar et al.
Introduction: Antimicrobial Peptides (AMPs) are intriguing alternatives to antibiotics for combating Multidrug-Resistant (MDR) pathogens; however, their clinical use is restricted by their rapid clearance, poor tissue pen...
Multi-Target Antioxidant Potential of Tricin Against Parkinson's Disease- Linked Oxidative Stress [0.03%]
天然黄酮类化合物山奈素的多靶抗氧化潜力及其对帕金森病氧化损伤的保护作用
Sushil Giri,Phool Chandra
Sushil Giri
Introduction: Oxidative stress (OS) is a key factor in the degeneration of dopaminergic neurons in Parkinson's disease (PD). It is closely associated with mitochondrial dysfunction, overproduction of reactive oxygen speci...