Quantitation of ligupurpurosides B and C in rat plasma using HPLC-MS/MS [0.03%]
使用HPLC-MS/MS定量测定大鼠血浆中Ligupurpurosides B和C的方法
Qian-Qian Chen,Jian-Ru Guo,Suo-Ming Feng et al.
Qian-Qian Chen et al.
The present study was designed to develop a sensitive and selective specific high performance liquid chromatography (HPLC)-tandem mass spectrometric method (MS/MS) for the determination of ligupurpurosides B and C in rat plasma. The samples...
Synthesis and cytotoxicity evaluation of 3-amino-2-hydroxypropoxyisoflavone derivatives [0.03%]
3-氨基-2-羟基丙氧基异黄酮衍生物的合成及细胞毒性评价
Jing-Jing Tang,Xiao-Ting Geng,Ya-Jing Wang et al.
Jing-Jing Tang et al.
Soy isoflavones exert a wide variety of biological activities, such as antioxidant, anti-inflammatory and anti-cancer properties. Nuclear factor erythroid 2-related factor 2 (Nrf2), a bZip transcription factor, plays a key role in soy isofl...
Chang-Long Xu,Jin-Xin Wang,Hui-Liang Li
Chang-Long Xu
In the present study, two new cyclic bisbibenzyls (1, 2) co-occuring with a known compound, isoplagiochins C (3) were isolated from Hebertus dicranus. The structures were determined mainly by extensive 1D and 2D NMR experiments, and the abs...
Bofutsushosan ameliorates obesity in mice through modulating PGC-1α expression in brown adipose tissues and inhibiting inflammation in white adipose tissues [0.03%]
半夏厚朴汤通过调节棕色脂肪组织中的PGC-1α表达及抑制白色脂肪组织的炎症改善肥胖小鼠表型
Ying-Ying Chen,Yan Yan,Zheng Zhao et al.
Ying-Ying Chen et al.
The inducible co-activator PGC-1α plays a crucial role in adaptive thermogenesis and increases energy expenditure in brown adipose tissue (BAT). Meanwhile, chronic inflammation caused by infiltrated-macrophage in the white adipose tissue (...
Zhi-Yi Yuan,Fan Lei,Yu-Shuang Chai et al.
Zhi-Yi Yuan et al.
Brazilein is an active small molecular compound extracted from Caesalpinia sappan L. with favorable pharmacological properties on immune system, cardiovascular system, and nervous system. C. sappan has been used as a traditional medicine in...
Gingerol activates noxious cold ion channel TRPA1 in gastrointestinal tract [0.03%]
姜酚激活消化道痛觉冷感受离子通道TRPA1
Meng-Qi Yang,Lin-Lan Ye,Xiao-Ling Liu et al.
Meng-Qi Yang et al.
TRPA1 channels are non-selective cation channels that could be activated by plant-derived pungent products, including gingerol, a main active constituent of ginger. Ginger could improve the digestive function; however whether ginger improve...
Cranberry extract supplementation exerts preventive effects through alleviating Aβ toxicity in Caenorhabditis elegans model of Alzheimer's disease [0.03%]
cranberry提取物补充通过缓解阿尔茨海默病秀丽隐杆线虫模型中的Aβ毒性发挥预防作用
Hong Guo,Yu-Qing Dong,Bo-Ping Ye
Hong Guo
Cranberry extract (CBE) rich in polyphenols are potent to delay paralysis induced by alleviating β-amyloid (Aβ) toxicity in C. elegans model of Alzheimer's disease (AD). In order to better apply CBE as an anti-AD agent efficiently, we sou...
An optimized micro-assay of myosin II ATPase activity based on the molybdenum blue method and its application in screening natural product inhibitors [0.03%]
基于钼蓝法的肌球蛋白ATP酶活微孔板测定及其天然产物抑制剂筛选应用
Hong-Lin Chen,Jing Zhao,Guan-Jun Zhang et al.
Hong-Lin Chen et al.
Myosin II plays multiple roles in physiological and pathological functions through its ATPase activity. The present study was designed to optimize a micro-assay of myosin II ATPase activity based on molybdenum blue method, using a known myo...
Estrogenic activity of osthole and imperatorin in MCF-7 cells and their osteoblastic effects in Saos-2 cells [0.03%]
补骨脂内酯和异欧前胡素的雌激素活性及其对破骨细胞的作用机制研究
Min Jia,Yuan Li,Hai-Liang Xin et al.
Min Jia et al.
There is an increasing interest in phytoestrogens due to their potential medical usage in hormone replacement therapy (HRT). The present study was designed to investigate the in vitro effects of estrogen-like activities of two widespread co...
Isoquercitrin suppresses the expression of histamine and pro-inflammatory cytokines by inhibiting the activation of MAP Kinases and NF-κB in human KU812 cells [0.03%]
异鼠李素通过抑制人类KU812细胞中MAP激酶和NF-κB的活化来抑制组胺及促炎症细胞因子的表达
Li Li,Xiao-Hui Zhang,Guang-Rong Liu et al.
Li Li et al.
Mast cells and basophils are multifunctional effector cells that contain abundant secretory granules in their cytoplasm. Both cell types are involved in a variety of inflammatory and immune events, producing an array of inflammatory mediato...