Traditional herbal formula Sini Powder extract produces antidepressant-like effects through stress-related mechanisms in rats [0.03%]
传统四逆汤提取物通过应激相关机制产生抗抑郁作用：对大鼠的研究
Shan-Shan Wei,He-Jin Yang,Jia-Wen Huang et al.
Shan-Shan Wei et al.
Sini Powder (SP), a traditional Chinese herbal formula, has long been used to treat depression in patients, although the underlying mechanisms remain to be elucidated. In the present study, we found that rats treated with SP extract for 7 d...
NAMPT inhibition synergizes with NQO1-targeting agents in inducing apoptotic cell death in non-small cell lung cancer cells [0.03%]
NAMPT抑制与NQO1靶向药物协同作用可诱导非小细胞肺癌细胞凋亡死亡
Hui-Ying Liu,Qing-Ran Li,Xue-Fang Cheng et al.
Hui-Ying Liu et al.
Nicotinamide phosphoribosyltransferase (NAMPT) catalyzes the first rate-limiting step in converting nicotinamide to NAD(+), essential for a number of enzymes and regulatory proteins involved in a variety of cellular processes, including dea...
Novel chinmedomics strategy for discovering effective constituents from ShenQiWan acting on ShenYangXu syndrome [0.03%]
基于肾阳虚证的中药新药研发策略研究——以金匮肾气丸中化合物群网络作用机制研究为例
Xiao-Hang Zhou,Ai-Hua Zhang,Liang Wang et al.
Xiao-Hang Zhou et al.
Elucidation of the efficacy of traditional Chinese medicine (TCM) is of importance for scientists of modern medicine to understand the value of TCM clinical experience, and it is necessary to have a biological language to scientifically des...
Screening and verifying potential NTCP inhibitors from herbal medicinal ingredients using the LLC-PK1 cell model stably expressing human NTCP [0.03%]
基于人源NTCP稳定表达的LLC-PK1细胞模型筛选和验证中药活性成分潜在的NTCP抑制剂
Zhuo-Wei Shen,Meng-Yue Luo,Hai-Hong Hu et al.
Zhuo-Wei Shen et al.
NTCP is specifically expressed on the basolateral membrane of hepatocytes, participating in the enterohepatic circulation of bile salts, especially conjugated bile salts, to maintain bile salts homeostasis. In addition, recent studies have ...
EPSAH, an exopolysaccharide from Aphanothece halophytica GR02, improves both cellular and humoral immunity as a novel polysaccharide adjuvant [0.03%]
来源于嗜盐红假单胞菌GR02的EPSAH通过充当新型多糖佐剂来改善细胞和体液免疫反应
Lei Zhu,Fan Zhang,Li-Jun Yang et al.
Lei Zhu et al.
EPSAH is an exopolysaccharide from Aphanothece halophytica GR02. The present study was designed to evaluate its toxicity and adjuvant potential in the specific cellular and humoral immune responses in ovalbumin (OVA) in mice. EPSAH did not ...
Effects of diammonium glycyrrhizinate on hepatic and intestinal UDP-Glucuronosyltransferases in rats: Implication in herb-drug interactions [0.03%]
甘草酸二铵对大鼠肝肠UGT酶的影响及潜在的中药相互作用研究
Fei-Yan Li,Hao Xie,Lin Weng et al.
Fei-Yan Li et al.
Glycyrrhizin is a major bioactive component of liquorice, which exerts multiple biochemical and pharmacological activities and is frequently used in combination with other drugs in the clinic. Mycophenolate mofetil (MMF), an immunosuppressa...
Anti-proliferative and apoptotic effects of S1, a tetrandrine derivative, in human gastric cancer BGC-823 cells [0.03%]
一种源自 Tetrandrine 的衍生物 S1 对人胃癌 BGC-823 细胞的增殖抑制和促凋亡作用
Rong-Rong Lei,Hai-Feng Hu,Fan Bai et al.
Rong-Rong Lei et al.
The aim of the study was to investigate the anti-proliferation and apoptosis-inducing effects of S1, a novel tetrandrine derivative, in human gastric cancer BGC-823 cells and explore the possible mechanism of action. The anti-proliferative ...
Berberine enhances antidiabetic effects and attenuates untoward effects of canagliflozin in streptozotocin-induced diabetic mice [0.03%]
番石榴碱可增强 канаглифロزين在链黴黴素诱导的糖尿病小鼠中的降糖作用并减轻其不良反应
Cai-Ming Tian,Xin Jiang,Xiao-Xi Ouyang et al.
Cai-Ming Tian et al.
The present study aimed at determining whether berberine can enhance the antidiabetic effects and alleviate the adverse effects of canagliflozin in diabetes mellitus. Streptozotocin-induced diabetic mice were introduced, and the combined ef...
A combination of four effective components derived from Sheng-mai san attenuates hydrogen peroxide-induced injury in PC12 cells through inhibiting Akt and MAPK signaling pathways [0.03%]
生脉散四种有效组分通过抑制Akt和MAPK信号通路减轻H₂O₂诱导的PC12细胞损伤
Guo-Sheng Cao,Shao-Xia Li,Yan Wang et al.
Guo-Sheng Cao et al.
The present study was designed to investigate whether a combination of four effective components derived from Sheng-mai san (SMXZF; ginsenoside Rb1: ginsenoside Rg1: DT-13: Schizandrol A as 6 : 9 : 4 : 5) could attenuate hydrogen peroxide (...
Siwu decoction attenuates oxonate-induced hyperuricemia and kidney inflammation in mice [0.03%]
四物汤通过减轻氧嗪酸诱导的高尿酸血症和小鼠肾脏炎症来发挥降尿酸作用
Rong Wang,Chun-Hua Ma,Fan Zhou et al.
Rong Wang et al.
The aim of the study was to investigate the effects of Siwu decoction on hyperuricemia, kidney inflammation, and dysfunction in hyperuricemic mice. Siwu decoction at 363.8, 727.5, and 1 455 mg·kg(-1) was orally administered to potassium ox...