Food-advanced glycation end products aggravate the diabetic vascular complications via modulating the AGEs/RAGE pathway [0.03%]
食物Advanced 糖基化 终产物 通过 调节 AGEs/RAGE 途径 加重 糖尿病 血管 并发症
Xing Lv,Gao-Hong Lv,Guo-Ying Dai et al.
Xing Lv et al.
The aim of this study was to investigate the effects of high-advanced glycation end products (AGEs) diet on diabetic vascular complications. The Streptozocin (STZ)-induced diabetic mice were fed with high-AGEs diet. Diabetic characteristics...
Prophylactic effects of alkaloids from Ba lotus seeds on L-NNA-induced hypertension in mice [0.03%]
莲须生物碱对L-NAME诱导的高血压小鼠的预防作用
Peng Sun,Kai Zhu,Cun Wang et al.
Peng Sun et al.
Alkaloids from Ba lotus seeds (ABLS) are a kind of important functional compounds in lotus seeds. The present study was designed to determine its hypertension prophylactic effects in the L-NNA-induced mouse hypertension model. The mice were...
Jiawei Erzhiwan improves menopausal metabolic syndrome by enhancing insulin secretion in pancreatic β cells [0.03%]
姬威儿治丸通过增强胰岛β细胞胰岛素分泌改善围绝经期代谢综合征
Xiao-Meng Wan,Mu Zhang,Pei Zhang et al.
Xiao-Meng Wan et al.
Menopausal metabolic syndrome (MMS) is a series of syndrome caused by ovarian function decline and hormone insufficiency, and is a high risk factor for cardiovascular diseases (CVD) and type II diabetes mellitus (T2DM). Erzhiwan (EZW), comp...
Protective effects of Huanglian Wendan Decoction aganist cognitive deficits and neuronal damages in rats with diabetic encephalopathy by inhibiting the release of inflammatory cytokines and repairing insulin signaling pathway in hippocampus [0.03%]
黄连温胆汤通过抑制炎症因子的释放及修复海马胰岛素信号通路治疗糖尿病脑病大鼠的认知障碍及神经元损伤的作用机制研究
Yue-Bi Li,Wei-Hua Zhang,Hua-Dong Liu et al.
Yue-Bi Li et al.
Huanglian Wendan decoction (HLWDD) has been used for the treatment of symptom of "Re", one of major causes in diabetes and metabolic disorders, according to the theory of traditional Chinese medicine. The present study aimed at investigatin...
The phenylalanine ammonia-lyase gene family in Isatis indigotica Fort.: molecular cloning, characterization, and expression analysis [0.03%]
菘蓝苯氨酶基因家族的克隆、特征和表达分析
Rui-Fang Ma,Qian-Zi Liu,Ying Xiao et al.
Rui-Fang Ma et al.
Phenolic compounds, metabolites of the phenylpropanoid pathway, play an important role in the growth and environmental adaptation of many plants. Phenylalanine ammonia-lyase (PAL) is the first key enzyme of the phenylpropanoid pathway. The ...
Pharmacokinetic profiles of falcarindiol and oplopandiol in rats after oral administration of polyynes extract of Oplopanax elatus [0.03%]
齿叶人参ployenes提取物口服给药后falcarindiol和oplopandiol的药动学行为研究
Wei Sun,Yi-Sheng He,Ling-Hui Xu et al.
Wei Sun et al.
Polyynes, such as facarindiol (FAD) and oplopandiol (OPD), are responsible for anticancer activities of Oplopanax elatus (O. elatus). A novel approach to pharmacokinetics determination of the two natural polyynes in rats was developed and v...
Nano-LC-ESI MS/MS analysis of proteins in dried sea dragon Solenognathus hardwickii and bioinformatic analysis of its protein expression profiling [0.03%]
干燥少鳞海龙的蛋白质组nanoLC-ESI MS/MS分析及生物信息学研究
Dong-Mei Zhang,Li-Xing Feng,Lu Li et al.
Dong-Mei Zhang et al.
The sea dragon Solenognathus hardwickii has long been used as a traditional Chinese medicine for the treatment of various diseases, such as male impotency. To gain a comprehensive insight into the protein components of the sea dragon, shotg...
Establishment and reliability evaluation of the design space for HPLC analysis of six alkaloids in Coptis chinensis (Huanglian) using Bayesian approach [0.03%]
基于贝叶斯方法的黄连供试品溶液中6种生物碱成分含量测定设计空间的确立及可靠性评估
Sheng-Yun Dai,Bing Xu,Yi Zhang et al.
Sheng-Yun Dai et al.
Coptis chinensis (Huanglian) is a commonly used traditional Chinese medicine (TCM) herb and alkaloids are the most important chemical constituents in it. In the present study, an isocratic reverse phase high performance liquid chromatograph...
Two new limonoids isolated from the fuits of Melia toosendan [0.03%]
两种苦参素类化合物及其对血管生成的抑制作用研究——苦参果中的两种查尔酮类成分
Qiong Zhang,Qing-Hong Zheng,Jing-Yu Liang et al.
Qiong Zhang et al.
In the present study, two new limonoids, 1α, 7α-dihydroxyl-3α-acetoxyl-12α-ethoxylnimbolinin (1) and 1α-tigloyloxy-3α-acetoxyl-7α-hydroxyl-12β-ethoxylnimbolinin (2), together with other four known limonoids (3-6), were isolated from...
A new biocompatible microemulsion increases extraction yield and bioavailability of Andrographis paniculata [0.03%]
一种新型生物相容性微乳提高andrographis paniculata提取率和生物利用度
Xiao-Yan Liu,Xin Niu,Qian-Jin Feng et al.
Xiao-Yan Liu et al.
The purpose of this study was to design and prepare a biocompatible microemulsion of Andrographis paniculata (BMAP) containing both fat-soluble and water-soluble constituents. We determined the contents of active constituents of BMAP and ev...