Comparative pharmacokinetics of bergenin, a main active constituent of Saxifraga stolonifera Curt., in normal and hepatic injury rats after oral administration [0.03%]
口服 bergenin 处理后健康和肝损伤大鼠体内主要活性成分岩白菜素的药代动力学比较研究
Rong-Hua Pan,Hong-Mei He,Yue Dai et al.
Rong-Hua Pan et al.
Bergenin, isolated from the herb of Saxifrage stolonifera Curt. (Hu-Er-Cao) has hepatoprotective, anti-inflammatory, antitussive, and neuroprotective activities. The aim of the present study was to establish a simple, rapid, and sensitive R...
LC-MS/MS analysis and pharmacokinetic study on five bioactive constituents of Tanreqing injection in rats [0.03%]
液相色谱-串联质谱法测定痰热清注射液中五个活性成分在大鼠体内的药动学参数
Feng Zhang,Liang Sun,Shou-Hong Gao et al.
Feng Zhang et al.
Tanreqing injection (TRQ), a well-known traditional Chinese medicine formula, is commonly used to treat respiratory diseases. In the present study, a rapid, selective, and sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) ...
Formulation of dried lignans nanosuspension with high redispersibility to enhance stability, dissolution, and oral bioavailability [0.03%]
一种具有高再分散性的干燥型木脂素纳米悬浮液的制备以增强稳定性、溶解度和口服生物利用度
Gang Shen,Ling Cheng,Li-Qiang Wang et al.
Gang Shen et al.
Herpetospermum caudigerum lignans (HTL), one of the potential drugs with anti-hepatitis B virus and hepatoprotective effects, has limited clinical applications because of poor aqueous solubility and low bioavailability. Both herpetrione (HP...
Petroleum ether sub-fraction of rosemary extract improves hyperlipidemia and insulin resistance by inhibiting SREBPs [0.03%]
迷迭香提取物石油醚亚分数通过抑制SREBPs改善高脂血症和胰岛素抵抗
Zhi-Shen Xie,Ling-Jun Zhong,Xiao-Meng Wan et al.
Zhi-Shen Xie et al.
As a culinary and medicinal herb, rosemary is widely used. The present work aimed to investigate the effects of rosemary extracts on metabolic diseases and the underlying mechanisms of action. Liver cells stably expressing SREBP reporter we...
Phytochemistry, pharmacology, and therapeutic uses of black seed (Nigella sativa) [0.03%]
黑种草子（Nigella sativa）的植物化学、药理学和治疗应用
Wesam Kooti,Zahra Hasanzadeh-Noohi,Naim Sharafi-Ahvazi et al.
Wesam Kooti et al.
Black seed (Nigella sativa) is an annual flowering plant from Ranunculaceae family, native to southwest Asia. This plant has many food and medicinal uses. The use of its seeds and oil is common for treatment of many diseases, including rheu...
Photochemistry and pharmacology of 9, 19-cyclolanostane glycosides isolated from genus Cimicifuga [0.03%]
单属боту利草的9, 19-环兰烷糖苷的光化学和药理学研究
Yang Su,Wen-Cheng Chi,Lun Wu et al.
Yang Su et al.
The constituents of Cimicifuga plants have been extensively investigated, and the principal metabolites are 9, 19-cyclolanostane triterpenoid glycosides, which often exhibit extensive pharmacological activities. 9, 19-Cyclolanostane triterp...
Identification of antioxidant activity of two new aromatic ring butyrolactone derivatives from Dictamnus dasycarpus Turcz [0.03%]
独活内酯抗氧化活性及其结构关系研究
Li-Na Guo,Yue-Hu Pei,Fei-Xiang Xie et al.
Li-Na Guo et al.
The present study carried out a phytochemical investigation on the root barks of Dictamnus dasycarpus Turcz, leading to the isolation and characterization of two new aromatic ring butyrolactone derivatives, dasycarpusphenol acid A (1) and d...
Isolation and characterization of two new 2-isobutylmalates from Bletilla striata [0.03%]
从白及中分离鉴定两种新的2-异丁基苹果酸类化合物
Huan-Yu Guan,Yan Yan,Yong-Lin Wang et al.
Huan-Yu Guan et al.
The present study isolated 17 compounds from the tubers of Bletilla striata (Orchidaceae), using various chromatographic techniques. Their structures were identified based on their physical-chemical properties and spectroscopic analyses. Am...
Isochlorogenic acid A affects P450 and UGT enzymes in vitro and in vivo [0.03%]
异氯ogenic酸A体内外影响P450和UGT酶
Jing Wang,Hong Wang,Ying Peng et al.
Jing Wang et al.
Isochlorogenic acid A (ICQA), which has anti-inflammatory, hepatoprotective, and antiviral properties, is commonly presented in fruits, vegetables, coffee, plant-based food products, and herbal medicines. These herbal medicines are usually ...
Agglutinin isolated from Arisema heterophyllum Blume induces apoptosis and autophagy in A549 cells through inhibiting PI3K/Akt pathway and inducing ER stress [0.03%]
天南星异形株提取的凝集素通过抑制PI3K/AKT途径和诱导内质网应激在A549细胞中诱导凋亡和自噬
Li-Xing Feng,Peng Sun,Tian Mi et al.
Li-Xing Feng et al.
Arisaema heterophyllum Blume is one of the three medicinal plants known as traditional Chinese medicine Rhizoma Arisaematis (RA). RA has been popularly used to treat patients with convulsions, inflammation, and cancer for a long time. Howev...