Magnolol inhibits appetite and causes visceral fat loss through Growth/differentiation factor-15 (GDF-15) by activating transcription factor 4-CCAAT enhancer binding protein γ-mediated endoplasmic reticulum stress responses [0.03%]
紫花前胡素通过激活转录因子4-CCAAT增强子结合蛋白γ介导的内质网应激反应，经由生长/分化因子-15 (GDF-15)途径抑制食欲并导致内脏脂肪流失
Keru Cheng,Yanyun Zhou,Yilong Hao et al.
Keru Cheng et al.
Magnolol, a compound extracted from Magnolia officinalis, demonstrates potential efficacy in addressing metabolic dysfunction and cardiovascular diseases. Its biological activities encompass anti-inflammatory, antioxidant, anticoagulant, an...
NUMB endocytic adaptor protein (NUMB) mediates the anti-hepatic fibrosis effect of artesunate (ART) by inducing senescence in hepatic stellate cells (HSCs) [0.03%]
NUMB内吞适应蛋白通过诱导肝星形细胞衰老介导了青蒿琥酯的抗肝纤维化作用
Yangling Qiu,Yujia Li,Mengran Li et al.
Yangling Qiu et al.
Developing and identifying effective medications and targets for treating hepatic fibrosis is an urgent priority. Our previous research demonstrated the efficacy of artesunate (ART) in alleviating liver fibrosis by eliminating activated hep...
Zishen Huoxue decoction (ZSHX) alleviates ischemic myocardial injury (MI) via Sirt5-β-tubulin mediated synergistic mechanism of "mitophagy-unfolded protein response" and mitophagy [0.03%]
滋肾活血方(ZSHX)通过Sirt5-β-微管蛋白介导的"线粒体自噬-未折叠蛋白反应"和线粒体自噬的协同机制减轻缺血性心肌损伤(MI)
Xing Chang,Siyuan Zhou,Yu Huang et al.
Xing Chang et al.
Zishen Huoxue decoction (ZSHX) enhances cardiomyocyte viability following hypoxic stress; however, its upstream therapeutic targets remain unclear. Network pharmacology and RNA sequencing analyses revealed that ZSHX target genes were closel...
Saponins from Aralia taibaiensis protect against brain ischemia/reperfusion injuries by regulating the apelin/AMPK pathway [0.03%]
Aralia taibaiensis皂苷通过调节апелин/AMPK通路保护脑缺血再灌注损伤
Zhengrong Li,Yuwen Liu,Kedi Liu et al.
Zhengrong Li et al.
Aralia taibaiensi, widely distributed in western China, particularly in the Qinba Mountains, has been utilized as a folk medicine for treating diabetes, gastropathy, rheumatism, and cardiovascular diseases. Saponins from A. taibaiensis (sAT...
Recent advances in regulating the cell cycle through inhibiting CDKs for cancer treatment [0.03%]
通过抑制CDKs调节细胞周期以治疗癌症的近期进展
Weijiao Chen,Xujie Zhuang,Yuanyuan Chen et al.
Weijiao Chen et al.
The inhibition of cyclin-dependent kinases (CDKs) is considered a promising strategy for cancer treatment due to their role in cell cycle regulation. However, CDK inhibitors with no selectivity among CDK families have not been approved. A C...
The prospect and underlying mechanisms of Chinese medicine in treating periodontitis [0.03%]
中医药治疗牙周炎的前景及其作用机制
Aili Xing,Feng Wang,Jinzhong Liu et al.
Aili Xing et al.
Inflammation represents a critical immune response triggered by cellular activities and inflammatory mediators following tissue damage. It plays a central role in the pathological progression of diverse diseases, including psychiatric disor...
Expanding molecular diversity of ribosomally synthesized and post-translationally modified peptide (RiPP) natural products by radical S-adenosylmethionine (SAM) enzymes: recent advances and mechanistic insights [0.03%]
通过自由基S-腺苷甲硫氨酸(SAM)酶扩大核糖体合成和翻译后修饰的肽(RiPP)天然产物的分子多样性：近期进展和机理见解
Jiawei Feng,Jiarong Mo,Xinya Hemu
Jiawei Feng
Ribosomally synthesized and post-translationally modified peptides (RiPPs) constitute a vast and diverse family of bioactive peptides. These peptides, synthesized by ribosomes and subsequently modified by various tailoring enzymes, possess ...
Neuroprotective and antidiabetic lanostane-type triterpenoids from the fruiting bodies of Ganoderma theaecolum [0.03%]
来自红芝子实体的具有神经营养和抗糖尿病作用的齐墩果烷型三萜类化合物
Jiaocen Guo,Li Yang,Luting Dai et al.
Jiaocen Guo et al.
Eight previously undescribed lanostane triterpenoids, including five nortriterpenoids with 26 carbons, ganothenoids A-E (1-5), and three lanostanoids, ganothenoids F-H (6-8), along with 24 known ones (9-32), were isolated from the fruiting ...
Ent-pimarane and ent-kaurane diterpenoids from Siegesbeckiapubescens and their anti-endothelial damage effect in diabetic retinopathy [0.03%]
毛蕊花植物中的倍半萜和抗糖尿病性视网膜病变的内皮损伤活性成分研究
Mengjia Liu,Tingting Luo,Rongxian Li et al.
Mengjia Liu et al.
Diabetic retinopathy, a prevalent and vision-threatening microvascular complication of diabetes mellitus, is the leading cause of blindness among middle-aged and elderly individuals. Natural diterpenoids isolated from Siegesbeckia pubescens...
Xanthones from Garcinia pedunculata and Garcinia nujiangensis and their anti-inflammatory activity [0.03%]
来自Garcinia pedunculata和Garcinia nujiangensis的黄酮及其抗炎活性
Xiaojie Fan,Yufeng Jia,Jiaxin Guo et al.
Xiaojie Fan et al.
Ten novel xanthones, garpedunxanthones A-G (1-5, 6a/6b, 7a/7b) and nujiangxanthone Q (8), along with sixteen known analogs (9-24), were isolated from Garcinia pedunculata and G. nujiangensis. Their structures were elucidated through high-re...