Hypaconitine inhibits TGF-β1-induced epithelial-mesenchymal transition and suppresses adhesion, migration, and invasion of lung cancer A549 cells [0.03%]
滇乌头碱对TGF-β1诱导的上皮间质转化的抑制作用及对肺癌A549细胞黏附、迁移和侵袭的抑制作用研究
Hai-Tao Feng,Wen-Wen Zhao,Jin-Jian Lu et al.
Hai-Tao Feng et al.
Epithelial-mesenchymal transition (EMT) has been implicated in tumor invasion and metastasis and provides novel strategies for cancer therapy. Hypaconitine (HpA), a diester-diterpenoid alkaloid isolated from the root of the Aconitum species...
Survey of traditional Dai medicine reveals species confusion and potential safety concerns: a case study on Radix Clerodendri Japonicum [0.03%]
对传统傣药的调查发现了物种识别错误和潜在的安全隐患：日本青木香为例的研究
Bao-Zhong Duan,Hai-Lan Fang,Xi-Wen Li et al.
Bao-Zhong Duan et al.
The adulteration of herbal products is a threat to consumer safety. In the present study, we surveyed the species composition of commercial Radix Clerodendri Japonicum products using DNA barcoding as a supervisory method. A reference databa...
Novel natural product therapeutics targeting both inflammation and cancer [0.03%]
兼具抗炎和抗癌作用的天然产物新药研究
Jiangjiang Qin,Wei Wang,Ruiwen Zhang
Jiangjiang Qin
Inflammation is recently recognized as one of the hallmarks of human cancer. Chronic inflammatory response plays a critical role in cancer development, progression, metastasis, and resistance to chemotherapy. Conversely, the oncogenic aberr...
Characterization and quantitation of aristolochic acid analogs in different parts of Aristolochiae Fructus, using UHPLC-Q/TOF-MS and UHPLC-QqQ-MS [0.03%]
采用UHPLC-Q/TOF-MS和UHPLC-QqQ-MS测定不同部位马兜铃果实中原生苷和次生苷类马兜铃酸类成分的含量及指认其结构类型
Wen-Wen Mao,Wen Gao,Zhi-Tao Liang et al.
Wen-Wen Mao et al.
Aristolochiae Fructus, a Chinese herbal medicine derived from the fruit of Aristolochia contorta Bge., contains nephrotoxic aristolochic acid analogues (AAAs). According to ancient medical texts, various medicinal parts of the fruit of A. c...
Identification of C-geranylated flavonoids from Paulownia catalpifolia Gong Tong fruits by HPLC-DAD-ESI-MS/MS and their anti-aging effects on 2BS cells induced by H2O2 [0.03%]
毛梾果HPLC-DAD-ESI-MS/MS指纹图谱研究及茋类成分抗氧化抗衰老作用机制分析
Wen-Zhao Tang,Ying-Ai Wang,Tian-Yang Gao et al.
Wen-Zhao Tang et al.
The fruits of Paulownia catalpifolia Gong Tong are used as a Chinese folk herbal medicine for the treatment of enteritis, tonsillitis, bronchitis, and dysentery, etc. Our previous study has identified new C-geranylated flavanones with obvio...
Mechanism for ginkgolic acid (15 : 1)-induced MDCK cell necrosis: Mitochondria and lysosomes damages and cell cycle arrest [0.03%]
银杏毒酸（15：1）诱导肾小管上皮细胞坏死的机制：线粒体和溶酶体损伤及细胞周期阻滞
Qing-Qing Yao,Zhen-Hua Liu,Ming-Cheng Xu et al.
Qing-Qing Yao et al.
Ginkgolic acids (GAs), primarily found in the leaves, nuts, and testa of ginkgo biloba, have been identified with suspected allergenic, genotoxic and cytotoxic properties. However, little information is available about GAs toxicity in kidne...
Nuclear magnetic resonance based metabolomic differentiation of different Astragali Radix [0.03%]
基于核磁共振代谢组学的两种黄耆根性状区别分析
Ai-Ping Li,Zhen-Yu Li,Ting-Li Qu et al.
Ai-Ping Li et al.
Astragali Radix (AR) is one of the most popular herbal medicines in traditional Chinese medicine (TCM). Wild AR is believed to be of high quality, and substitution with cultivated AR is frequently encountered in the market. In the present s...
A lipophilic prodrug of Danshensu: preparation, characterization, and in vitro and in vivo evaluation [0.03%]
丹参素脂溶性前药的制备、表征及体内外评价
Xue-Jiao Guo,Xue-Jiao Fan,Bin Qiao et al.
Xue-Jiao Guo et al.
Danshensu [3-(3, 4-dihydroxyphenyl) lactic acid, DSS], one of the significant cardioprotective components, is extracted from the root of Salvia miltiorrhiza. In the present study, an ester prodrug of Danshensu (DSS), palmitoyl Danshensu (PD...
Synthesis and evaluation of 2-cyano-3, 12-dioxooleana-1, 9(11)-en-28-oate-13β, 28-olide as a potent anti-inflammatory agent for intervention of LPS-induced acute lung injury [0.03%]
2-氰基-3, 12-乌头烷二酮-1, 9(11)-烯-28-丙酸-13β，28-内酯的合成及其作为潜在抗炎剂防治LPS致急性肺损伤的研究
Yi Mou,Yan-Lin Jian,Tong Chen et al.
Yi Mou et al.
The present study was designed to synthesize 2-Cyano-3, 12-dioxooleana-1, 9(11)-en-28-oate-13β, 28-olide (1), a lactone derivative of oleanolic acid (OA) and evaluate its anti-inflammatory activity. Compound 1 significantly diminished nitr...
Triptolide reduces prostate size and androgen level on testosterone-induced benign prostatic hyperplasia in Sprague Dawley rats [0.03%]
三氧化二醒可缩小良性前列腺增生大鼠的前列腺体积并降低雄性激素水平
Yu-Rong Wang,Yuan Xu,Zhen-Zhou Jiang et al.
Yu-Rong Wang et al.
Benign prostatic hyperplasia (BPH) is an age-related disease of unknown etiology, characterized by prostatic enlargement coincident with distinct alterations in tissue histology. In the present study, we investigated whether triptolide can ...