GTS40, an active fraction of Gou Teng-San (GTS), protects PC12 from H2O2-induced cell injury through antioxidative properties [0.03%]
钩藤散的活性部位GTS40通过抗氧化作用保护H2O2诱导的PC12细胞损伤
Lei Chen,Meng-Lin Wei,Jiao-Jiao Zhao et al.
Lei Chen et al.
Oxidative stress, a predominant cause of apoptosis cascades triggered in neurodegenerative disorders, has been regarded as a critical inducement in the pathogenesis of Alzheimer's disease (AD). Gou Teng-San (GTS) is a traditional Chinese he...
Polymyxin B as an inhibitor of lipopolysaccharides contamination of herb crude polysaccharides in mononuclear cells [0.03%]
多粘菌素B抑制中药粗多糖中内毒素污染的作用研究
Xiao-Xiao Lu,Yi-Fan Jiang,Hong Li et al.
Xiao-Xiao Lu et al.
Lipopolysaccharides (LPS) contamination in herbal crude polysaccharides is inevitable. The present study was performed to explore the effect of polymyxin B on abolishing the influence of LPS contamination in mononuclear cells. LPS was pretr...
Identification of processed Chinese medicinal materials using DNA mini-barcoding [0.03%]
基于DNA条形码鉴定中药饮片物种真实性研究
Ming Song,Gang-Qiang Dong,Ya-Qin Zhang et al.
Ming Song et al.
Most of Chinese medicinal herbs are subjected to traditional processing procedures, including stir-frying, charring, steaming, boiling, and calcining before they are released into dispensaries. The marketing and identification of processed ...
UPLC/ESI-QTOF-MS-based metabolomics survey on the toxicity of triptolide and detoxication of licorice [0.03%]
基于UPLC/ESI-QTOF-MS的代谢组学研究三氧化二砷的毒性及甘草解毒作用
Zhuo Wang,Jian-Qun Liu,Jin-Di Xu et al.
Zhuo Wang et al.
Triptolide (TP) from Tripterygium wilfordii has been demonstrated to possess anti-inflammatory, immunosuppressive, and anticancer activities. TP is specially used for the treatment of awkward rheumatoid arthritis, but its clinical applicati...
Bioassay-guided isolation of saikosaponins with agonistic activity on 5-hydroxytryptamine 2C receptor from Bupleurum chinense and their potential use for the treatment of obesity [0.03%]
基于生物测定的中药柴胡中激动5-羟色胺2C受体的柴胡皂苷的分离及其潜在抗肥胖功效研究
Chang-Li Sun,Chang-An Geng,Xiao-Yan Huang et al.
Chang-Li Sun et al.
5-Hydroxytryptamine 2C (5-HT2C) receptor is one of the major targets of anti-obesity agents, due to its role in regulation of appetite. In the present study, the 70% EtOH extract of the roots of Bupleurum chinense was revealed to have agoni...
Triterpenoid saponins from the roots of Cyathula officinalis and their inhibitory effects on nitric oxide production [0.03%]
Cyathula officinalis根中三萜皂苷的分离鉴定及其抑制NO生成作用
Yun-Tao Jiang,Wen-Jing Yan,Chu-Lu Qi et al.
Yun-Tao Jiang et al.
The present study was designed to investigate the chemical constituents of the roots of Cyathula officinalis. Compounds were isolated by silica gel, Sephadex LH-20, ODS column chromatography, and preparative HPLC. Their structures were dete...
Two new diterpenoid lactones isolated from Andrographis paniculata [0.03%]
_evaluation_andropogin_k和_andropogen_k是从andrographis_paniculata中分离得到的两个新的二萜内酯化合物
Gui-Yang Wang,Ting Wen,Fei-Fei Liu et al.
Gui-Yang Wang et al.
In the present study, two new diterpenoid lactones, 3-deoxy-andrographoside (1) and 14-deoxy-15-methoxy-andrographolide (2), were isolated from the aerial parts of Andrographis paniculata. Their structures were elucidated by combination of ...
Enhanced absorption and inhibited metabolism of emodin by 2, 3, 5, 4'-tetrahydroxystilbene-2-O-β-D-glucopyranoside: Possible mechanisms for Polygoni Multiflori Radix-induced liver injury [0.03%]
2，3，5，4′-四羟基 stilbene-2-O-β-d-葡萄吡喃糖苷对大黄素吸收代谢的调控作用及机制研究
Qiong Yu,Li-Long Jiang,Na Luo et al.
Qiong Yu et al.
Polygoni Multiflori Radix (PMR) has been commonly used as a tonic in China for centuries. However, PMR-associated hepatotoxicity is becoming a safety issue. In our previous in vivo study, an interaction between stilbenes and anthraquinones ...
Heparin-derived oligosaccharide inhibits vascular intimal hyperplasia in balloon-injured carotid artery [0.03%]
肝素寡糖抑制血管内膜增生作用的研究
Jie-Ru Liu,Jie Wu,Xin-Chao Yu et al.
Jie-Ru Liu et al.
The aims of the present study were to determine the effects of heparin-derived oligosaccharides (HDOs) on vascular intimal hyperplasia (IH) in balloon-injured carotid artery and to elucidate the underlying mechanisms of action. An animal mo...
Design of new traditional Chinese medicine herbal formulae for treatment of type 2 diabetes mellitus based on network pharmacology [0.03%]
基于网络药理学的2型糖尿病新复方中药设计研究
Rui-Feng Hu,Xiao-Bo Sun
Rui-Feng Hu
In the present study, 28 Chinese medicinal herbs belonging to traditional Chinese medicine (TCM) for the treatment of type 2 diabetes were selected to explore the application of network pharmacology in developing new Chinese herbal medicine...