Anti-proliferation activity of terpenoids isolated from Euphorbia kansui in human cancer cells and their structure-activity relationship [0.03%]
来源于祁州胎的倍半萜类抗肿瘤活性及其构效关系研究
Jin-Jun Hou,Yao Shen,Zhou Yang et al.
Jin-Jun Hou et al.
Euphorbia kansui is a commonly used traditional Chinese medicine for the treatment of edema, pleural effusion, and asthma, etc. According to the previous researches, terpenoids in E. kansui possess various biological activities, e.g., anti-...
Neuroprotective effects of Yiqihuoxue calm wind capsule on ischemic stroke in rats [0.03%]
益气活血熄风胶囊对缺血性卒中大鼠的神经保护作用
Jun-Xia Zhang,Jiao-Mei Guo,Hong-Jun Lin et al.
Jun-Xia Zhang et al.
Stroke remains the third leading cause of death and of adult disability worldwide. Vascular occlusion, followed by ischemic cascade, leads to irreversible tissue injury. Recombinant tissue plasminogen activator is the only FDA approved drug...
Ginsenoside Rk1 suppresses pro-inflammatory responses in lipopolysaccharide-stimulated RAW264.7 cells by inhibiting the Jak2/Stat3 pathway [0.03%]
原人参二醇型皂苷Rk1通过抑制Jak2/Stat3信号通路抑制LPS诱导的RAW264.7细胞炎症反应
Qian Yu,Ke-Wu Zeng,Xiao-Li Ma et al.
Qian Yu et al.
The saponin ginsenoside Rk1 is a major compound isolated from ginseng. Ginsenoside Rk1 has been reported to have anti-inflammatory and anti-tumor properties and to be involved in the regulation of metabolism. However, the effect and mechani...
Protective effect of Shouwu Yizhi decoction against vascular dementia by promoting angiogenesis [0.03%]
首乌益智汤通过促进血管新生防治血管性痴呆的作用研究
Xiao-Ni Yang,Chang-Sheng Li,Chao Chen et al.
Xiao-Ni Yang et al.
Shouwu is a traditional Chinese medicine (TCM) with neuroprotective effect. Shouwu Yizhi decoction (SYD) was designed based on TCM theory. However, little is known about the roles of SYD in Vascular dementia (VaD). The present study aimed t...
Pomegranate leaf attenuates lipid absorption in the small intestine in hyperlipidemic mice by inhibiting lipase activity [0.03%]
番石榴叶通过抑制脂肪酶活性削弱小肠脂质吸收以改善高血脂小鼠的血清脂质指标
Xuan Yu,Xin-Pei Wang,Fan Lei et al.
Xuan Yu et al.
Pomegranate leaf (PGL) has a definite role in regulating lipid metabolism. However, pharmacokinetic results show the main active ingredient, ellagic acid, in PGL has lower oral bioavailability, suggesting that the lipid-lowering effect of P...
Advances in extraction and analysis of phenolic compounds from plant materials [0.03%]
植物材料酚类化合物提取与分析研究进展
Cong-Cong Xu,Bing Wang,Yi-Qiong Pu et al.
Cong-Cong Xu et al.
Phenolic compounds, the most abundant secondary metabolites in plants, have received more and more attention in recent years because of their distinct bioactivities. This review summarizes different types of phenolic compounds and their ext...
An UHPLC-MS/MS method for simultaneous determination of quercetin 3-O-rutinoside, kaempferol 3-O-rutinoside, isorhamnetin 3-O-rutinoside, bilobalide and ligustrazine in rat plasma, and its application to pharmacokinetic study of Xingxiong injection [0.03%]
一种同时测定鼠血浆中芸香苷、山柰酚芸香糖苷、杨梅素芸香糖苷、银杏内酯和丁香树脂酚的UHPLC-MS/MS方法及其在注射红花药代动力学研究中的应用
Li-Li Dou,Li Duan,Long Guo et al.
Li-Li Dou et al.
The present study was designed to develop and validate a rapid, sensitive, and reliable ultra-high performance liquid chromatography coupled with tandem mass spectrometry (UHPLC-MS/MS) method for the simultaneous determination of five major...
A new approach for identification of medicinal almonds by fourier transform infrared spectroscopy and systematic clustering of characteristic peaks [0.03%]
基于特征峰系统聚类的红外光谱识别药用杏仁的新方法研究
Chun-Song Cheng,Can-Jian Wang,Jie Liang et al.
Chun-Song Cheng et al.
Medicinal almonds have been used for over 2 000 years and its clinical efficacy includes relieving cough and asthma. The domestic market in China is flooded with different kinds of dried almonds, such as bitter almond (Armeniacae Semen Amar...
Identification of human cytochrome P450 and UGT enzymes involved in the metabolism of ferulic acid, a major bioactive component in traditional Chinese medicines [0.03%]
参与大黄素代谢的药物代谢酶鉴定研究
Xiao-Mei Zhuang,Lin Chen,Yan Tan et al.
Xiao-Mei Zhuang et al.
Ferulic acid (FA) is an active component of herbal medicines. One of the best documented activities of FA is its antioxidant property. Moreover, FA exerts antiallergic, anti-inflammatory, and hepatoprotective effects. However, the metabolic...
Combination of LC/MS and GC/MS based metabolomics to study the hepatotoxic effect of realgar nanoparticles in rats [0.03%]
结合LC/MS和GC/MS代谢组学研究雄黄纳米颗粒肝毒性效应
Mo-Han Zhang,Jia-Qing Chen,Hui-Min Guo et al.
Mo-Han Zhang et al.
Realgar nanoparticles (NPs) are increasingly used as therapeutic agents for their enhanced anti-proliferation effect and cytotoxicity on cancer cells. However, the alteration of particle size may enhance biological reactivity as well as tox...