New diterpenoids isolated from Leonurus japonicus and their acetylcholinesterase inhibitory activity [0.03%]
日本母亲草中两种新的倍半萜及对乙酰胆碱酯酶的抑制作用
Han-Kui Wu,Ting Sun,Feng Zhao et al.
Han-Kui Wu et al.
Three new labdane diterpenoids, leojaponicone A (1), isoleojaponicone A (2) and methylisoleojaponicone A (3), were isolated from the herb of Leonurus japonicus. The chemical structures of these secondary metabolites were elucidated on the b...
Clavuridins A and B, two new trinor-guaiane sesquiterpenes isolated from the Xisha soft coral Clavularia viridis [0.03%]
来自西沙海绵硬骨酸软珊瑚Clavularia viridis的两个新的三去甲基guaiane倍半萜茋类衍生物 клавуридины A и B
Yuan Gao,Wei Xiao,Hong-Chun Liu et al.
Yuan Gao et al.
In the present study, two new trinor-guaiane sesquiterpenes, named clavuridins B (1), and A (2), along with three known sesquiterpenes (3-5), were isolated from the Xisha soft coral Clavularia viridis. Their structures and absolute configur...
Early intervention with Didang decoction delays macrovascular lesions in diabetic rats through regulating AMP-activated protein kinase signaling pathway [0.03%]
早期应用涤荡汤干预通过调节AMPK信号通路延缓糖尿病大鼠MacroVG病变形成
Dan-Dan Ren,Jing Li,Bai Chang et al.
Dan-Dan Ren et al.
The study aimed to investigate the intervening role of Didang decoction (DDD) at different times in macrovascular endothelial defense function, focusing on its effects on the AMP-activated protein kinase (AMPK) signaling pathway. The effect...
Bacopa monnieri extracts prevent hydrogen peroxide-induced oxidative damage in a cellular model of neuroblastoma IMR32 cells [0.03%]
巴革菜提取物可预防过氧化氢诱导的神经母细胞瘤IMR32细胞系模型中的氧化损伤
Gaurav Bhatia,Vikram Dhuna,Kshitija Dhuna et al.
Gaurav Bhatia et al.
Neurodegenerative diseases are the consequences of imbalance between the production of oxidative stress and its nullification by cellular defense mechanisms. Hydrogen peroxide (H2O2), a precursor of deleterious reactive oxygen species, elic...
Garcinia xanthochymus extract protects PC12 cells from H2O2-induced apoptosis through modulation of PI3K/AKT and NRF2/HO-1 pathways [0.03%]
Garcinia xanthochymus提取物通过调节PI3K/AKT和NRF2/HO-1通路保护PC12细胞免受H2O2诱导的凋亡作用
Jing Xu,Sheng Gan,Jun Li et al.
Jing Xu et al.
The aim of the present study was to investigate the protective effects and underlying mechanisms of Garcinia xanthochymus, a perennial medicinal plant native to Yunnan, China, against H2O2-induced oxidative damage in rat pheochromacytoma PC...
Polyphenols isolated from Acacia mearnsii bark with anti-inflammatory and carbolytic enzyme inhibitory activities [0.03%]
具有抗炎和碳酰酶抑制作用的Acacia mearnsii树皮中分离出的多酚类化合物
Jia Xiong,Mary H Grace,Debora Esposito et al.
Jia Xiong et al.
The present study was designed to characterize the polyphenols isolated from Acacia mearnsii bark crude extract (B) and fractions (B1-B7) obtained by high-speed counter-current chromatography (HSCCC) and evaluate their anti-inflammatory and...
Zhan-Peng Shang,Fei Wang,Jia-Yu Zhang et al.
Zhan-Peng Shang et al.
Liriope (Liliaceae) species have been used as folk medicines in Asian countries since ancient times. From Liriope plants (8 species), a total of 132 compounds (except polysaccharides) have been isolated and identified, including steroidal s...
A quantitative analytical method for valienone and its application in the evaluation of valienone production by a breakthrough microbial process [0.03%]
一种定量分析香柑内酯的方法及在突破性微生物合成中的应用
Li Cui,Karin Yanagi,Ting Shi et al.
Li Cui et al.
Valienone is a significant natural carbasugar member of the C7-cyclitol family as a valuable precursor for glycosidase inhibitor drugs. It is an intermediate of validamycin A biosynthesis pathway and exhibits minimal accumulation in the fer...
Characterization of molecular signature of the roots of Paeonia lactiflora during growth [0.03%]
牡丹根生长过程中的分子特征研究
Pei Liu,Yuan Xu,Hui Yan et al.
Pei Liu et al.
The roots of Paeoniae lactiflora Pall. are widely consumed as crude drugs in Asian countries due to their remarkable beneficial health effects. The present research was undertaken to illuminate the dynamic changes in metabolites and enzymes...
Pharmacokinetics of the prototype and hydrolyzed carboxylic forms of ginkgolides A, B, and K administered as a ginkgo diterpene lactones meglumine injection in beagle dogs [0.03%]
原型及水解羧基化苦参碱在比格犬体内药代动力学研究
Shu-Yao Wang,Ji-Ye A,Fei Fei et al.
Shu-Yao Wang et al.
Ginkgo diterpene lactones meglumine injection (GDLI) is a commercially available product used for neuroprotection. However, the pharmacokinetic properties of the prototypes and hydrolyzed carboxylic forms of the primary components in GDLI, ...