Taxus chinensis ameliorates diabetic nephropathy through down-regulating TGF-β1/Smad pathway [0.03%]
唐松草通过下调TGF-β1/Smad信号通路改善糖尿病肾病
Hong-Bo Weng,Wen-Ke Han,Yan-Wen Xiong et al.
Hong-Bo Weng et al.
Diabetic nephropathy (DN) is one of the common microvascular complications of diabetes mellitus. Renal fibrosis is closely related to the deterioration of renal function. The present study aimed to investigate protective effect of Taxus chi...
Morphological and chemical studies of artificial Andrographis paniculata polyploids [0.03%]
人工穿心莲多倍体的形态和化学研究
Qi-Qing Li,Jian Zhang,Ji-Hua Liu et al.
Qi-Qing Li et al.
Andrographis paniculata (Burm. f.) Nees (AP) is commonly used for the treatment of many infectious diseases and has been cultivated widely in Asian countries, and has been included in United States Pharmacopoeia as a dietary supplement, but...
Rapid screening and identification of sesquiterpene lactones in Kudiezi injection based on high-performance liquid chromatography coupled with linear ion trap-orbitrap mass spectrometry [0.03%]
基于高效液相色谱与线性离子阱-轨道肼质谱联用的苦地丁注射液倍半内酯类成分的快速筛查及鉴定研究
Rong-Rong Liu,Xiu-Ping Zhang,Fang Wang et al.
Rong-Rong Liu et al.
Sesquiterpene lactones are considered as the major active compounds in Kudiezi injection in virtue of their special structures and activities. Herein, an analytical method was developed for rapid screening and identification of sesquiterpen...
Enhancement of oral bioavailability and immune response of Ginsenoside Rh2 by co-administration with piperine [0.03%]
胡椒碱共轭给药改善Ginsenoside Rh2口服生物利用度和免疫反应
Zhao-Hui Jin,Wen Qiu,Hui Liu et al.
Zhao-Hui Jin et al.
Ginsenoside Rh2 (Rh2) is one of the major bioactive ginsenosides in Panax ginseng. However, the oral bioavailability of Rh2 is low, with P-glycoprotein (P-gp) and CYP3A4 being reported to be the main factors. The purpose of the present stud...
Jing DU,Jie Ding,Zhen-Qiang Mu et al.
Jing DU et al.
The present study was designed to determine the chemical constituents of the stem tuber of Pinellia pedatisecta. The chemical constituents were isolated and purified by various chromatographic techniques, and their structures were elucidate...
Novel triterpene saponins isolated from Clematis mandshurica and their inhibitory activities on NO production [0.03%]
Clematis mandshurica 中分离得到的三萜皂苷及其抑制NO生成的作用
Qiang Fu,Min Yang,Yu Ma et al.
Qiang Fu et al.
Four new triterpene saponins, mandshunosides F-I (1-4), together with five known compounds (5-9), were isolated from the roots and rhizomes of Clematis mandshurica. Their structures were elucidated on the basis of spectroscopic evidences an...
Enhancement of gut permeation of amoxicillin with Nigella sativa seed extract and its phytochemical screening [0.03%]
Nigella sativa种子提取物增强阿莫西林肠道通透性及其植化筛选研究
Babar Ali,Mohammad Ali,Saima Amin et al.
Babar Ali et al.
The seeds of Nigella sativa Linn. (Ranunculaceae), commonly known as Black cumin, are predominantly used as carminative, antispasmodic, and stimulant. The main objective of the present study was to evaluate the effect of N. sativa seed extr...
Synthesis and biological evaluation of novel tanshinone IIA derivatives for treating pain [0.03%]
新型丹参素乙二酸衍生物的合成及镇痛活性研究
Qi-Nan Li,Zhi-Peng Huang,Qin-Lan Gu et al.
Qi-Nan Li et al.
Due to ineffectiveness and side effects of existing analgesics, chronic pain has become one of the most complex and difficult problems in the clinic. Monoacylglycerol lipase (MAGL) is an essential hydrolase in the endocannabinoid system and...
Anti-inflammatory effect of external use of escin on cutaneous inflammation: possible involvement of glucocorticoids receptor [0.03%]
escin外用抗炎作用及对糖皮质激素受体的影响
Shu-Qi Zhao,Shi-Qiang Xu,Jing Cheng et al.
Shu-Qi Zhao et al.
Escin, as an internally applied anti-inflammatory agent, has been widely used in the treatment of inflammation and edema resulting from trauma or operation in the clinic. However, the effect of its external use on cutaneous inflammation and...
Improved stability and oral bioavailability of Ganneng dropping pills following transforming lignans of herpetospermum caudigerum into nanosuspensions [0.03%]
滇天南星茋类成分纳米化提高天龙滴丸的稳定性及口服生物利用度
Juan-Juan Li,Ling Cheng,Gang Shen et al.
Juan-Juan Li et al.
The present study was designed to improve storage stability and oral bioavailability of Ganneng dropping pills (GNDP) by transforming lignans of Herpetospermum caudigerum (HL) composed of herpetrione (HPE) and herpetin (HPN) into nanosuspen...