Xiaohuang Qudan decoction alleviates ANIT-induced cholestatic liver injury by inhibiting the JAK2/STAT3 pathway and regulating TH17/Treg [0.03%]
小黄芩旦汤通过抑制JAK2/STAT3信号通路及调控TH17/Treg平衡治疗ANIT致肝胆汁淤积损伤
Zhangkui Tan,Lifeng Chen,Zhiqin Ye et al.
Zhangkui Tan et al.
Xiaohuang Qudan decoction (XHQDD) is a classical traditional Chinese medicine (TCM) formula widely used in the treatment of cholestatic liver injury. Despite its widespread use, the protective mechanism of XHQDD against cholestatic liver in...
Esculetin triggers ferroptosis via inhibition of the Nrf2-xCT/GPx4 axis in hepatocellular carcinoma [0.03%]
Esculetin通过抑制Nrf2-xCT/GPx4轴触发肝癌细胞铁死亡
Zhixin Qu,Jing Zeng,Laifeng Zeng et al.
Zhixin Qu et al.
Esculetin, a natural dihydroxy coumarin derived from the Chinese herbal medicine Cortex Fraxini, has demonstrated significant pharmacological activities, including anticancer properties. Ferroptosis, an iron-dependent form of regulated cell...
Emd-D inhibited ovarian cancer progression via PFKFB4-dependent glycolysis and apoptosis [0.03%]
EMD-D通过依赖PFKFB4的糖酵解和凋亡抑制卵巢癌进展
Xin Zhao,Chao Chen,Xuefei Feng et al.
Xin Zhao et al.
Ovarian cancer poses a significant threat to women's health, necessitating effective therapeutic strategies. Emd-D, an emodin derivative, demonstrates enhanced pharmaceutical properties and bioavailability. In this study, Cell Counting Kit ...
Total alkaloids from Thesium chinense inhibit lipopolysaccharide-induced respiratory inflammation by modulating Nrf2/NF-κB/NLRP3 signaling pathway [0.03%]
中国冬青豆总生物碱通过调节Nrf2/NF-κB/NLRP3信号通路抑制脂多糖诱导的呼吸道炎症作用研究
Guohui Li,Yueqin Guan,Lintao Xu et al.
Guohui Li et al.
Inflammation plays a pivotal role in the etiology and progression of various diseases. In traditional Chinese medicine, the whole plants of Thesium chinense Turcz. and its preparations (e.g. Bairui Granules) have been employed to manage inf...
Mass spectral database-based methodologies for the annotation and discovery of natural products [0.03%]
基于质谱数据库的天然产物注释和鉴定方法学研究进展
Fengyao Yang,Zeyuan Liang,Haoran Zhao et al.
Fengyao Yang et al.
Natural products (NPs) have long held a significant position in various fields such as medicine, food, agriculture, and materials. The chemical space covered by NPs is extensive but often underexplored. Therefore, high-throughput and effici...
Yaoyao Lai,Bing Xie,Wanting Zhang et al.
Yaoyao Lai et al.
Pure drug nanomedicines (PDNs) encompass active pharmaceutical ingredients (APIs), including macromolecules, biological compounds, and functional components. They overcome research barriers and conversion thresholds associated with nanocarr...
New acylphloroglucinol-sesquiterpenoid adducts with antiviral activities from Dryopteris atrata [0.03%]
Dryopteris atrata中新具有抗病毒活性的酰基菲咯啉-倍半萜缩合物
Jihui Zhang,Jinghao Wang,Wei Tang et al.
Jihui Zhang et al.
Seven novel acylphloroglucinol-sesquiterpenoid adducts, designated as dryatraols J-P (1-7), were isolated from the rhizomes of Dryopteris atrata (Wall. ex Kunze) Ching. The structures, including absolute configurations, were elucidated usin...
Discovery of fernane-type triterpenoids from Diaporthe discoidispora using genome mining and HSQC-based SMART technology [0.03%]
利用基因组挖掘和HSQC-based SMART技术发现Diaporthe discoidispora中的蕨甾烷类三萜化合物
Yajing Wang,Yongfu Li,Yan Dong et al.
Yajing Wang et al.
In this study, we employed a combination of genome mining and heteronuclear single quantum coherence (HSQC)-based small molecule accurate recognition technology (SMART) technology to search for fernane-type triterpenoids. Initially, potenti...
Ziyuglycoside II suppressed the progression of osteosarcoma by coordinating estrogen-related receptor gamma and p53 signaling pathway [0.03%]
紫草甘II通过协调雌激素相关受体γ和p53信号通路抑制骨肉瘤进展
Hang Du,Dongjin Wu,Tianyu Zhang et al.
Hang Du et al.
Osteosarcoma (OS) is the most prevalent primary malignant bone tumor affecting children and adolescents. Despite ongoing research efforts, the 5-year survival rate has remained stagnant for many years, highlighting the critical need for nov...
Ustusolate E and 11α-Hydroxy-Ustusolate E induce apoptosis in cancer cell lines by regulating the PI3K/AKT/mTOR and p-53 pathways [0.03%]
Ustusolate E和11α-Hydroxy-Ustusolate E通过调节PI3K/AKT/mTOR和p-53途径诱导癌细胞系凋亡
Mewlude Rehmutulla,Sitian Zhang,Jie Yin et al.
Mewlude Rehmutulla et al.
Cancer represents a significant disease that profoundly impacts human health and longevity. Projections indicate a 47% increase in the global cancer burden by 2040 compared to 2020, accompanied by a further rise in the associated economic b...