Madecassoside impedes invasion of rheumatoid fibroblast-like synoviocyte from adjuvant arthritis rats via inhibition of NF-κB-mediated matrix metalloproteinase-13 expression [0.03%]
马洛替酯通过抑制NF-κB介导的基质金属蛋白酶-13表达来阻止II型胶原诱导的关节炎小鼠滑膜纤维样细胞侵袭
Wei-Guang Yu,Yong Shen,Jian-Zhong Wu et al.
Wei-Guang Yu et al.
Fibroblast-like synoviocytes (FLS) play a pivotal role in Rheumatoid arthritis (RA) pathogenesis through aggressive migration and invasion. Madecassoside (Madec), a triterpenoid saponin present in Centella asiatica herbs, has a potent anti-...
Osthole decreases collagen I/III contents and their ratio in TGF-β1-overexpressed mouse cardiac fibroblasts through regulating the TGF-β/Smad signaling pathway [0.03%]
补骨脂内酯通过调节TGF-β/Smad信号途径降低转化生长因子-β1过表达的小鼠心肌纤维细胞中I型和III型胶原含量及二者比例
Jin-Cheng Liu,Lei Zhou,Feng Wang et al.
Jin-Cheng Liu et al.
The present study was designed to elucidate whether the mechanism by which osthole decreases collagenI/III contents and their ratio is regulating the TGF-β/Smad signaling pathway in TGF-β1-overexpressed mouse cardiac fibroblasts (CFs). Th...
An UPLC-MS/MS method for simultaneous determination of multiple constituents in Guizhi Fuling capsule with ultrafast positive/negative ionization switching [0.03%]
超快正负离子切换的UPLC-MS/MS联用技术在桂枝茯苓胶囊多成分同时测定中的应用研究
Rong-Hua Zhang,Chao-Ran Li,Hua Yang et al.
Rong-Hua Zhang et al.
Guizhi Fuling capsule (GFC), a traditional Chinese medicine (TCM) with effects of promoting blood circulation and dissipating blood stasis, has been widely used in the clinic. Because of the complex matrix and various chemical structure typ...
Screening and analysis of key active constituents in Guanxinshutong capsule using mass spectrum and integrative network pharmacology [0.03%]
基于质谱及整合网络药理学的冠心舒通胶囊关键活性成分筛选与分析
Feng Liu,Xia DU,Pei-Rong Liu et al.
Feng Liu et al.
Guanxinshutong capsule (GXSTC) is an effective and safe traditional Chinese medicine used in the treatment of cardiovascular diseases (CVDs) for many years. However, the targets of this herbal formula and the underlying molecular mechanisms...
Formulation development and evaluation of gastroretentive floating beads with Brucea javanica oil using ionotropic gelation technology [0.03%]
采用离子交联技术制备并评价含 Brake javanica 油的胃滞留型浮动微球处方研究
Yue Zhang,Xi-Tong Zhang,Qi Zhang et al.
Yue Zhang et al.
In the present study, a gastric retention floating system for Brucea javanica oil, composed of alginate and carrageenan, was prepared using ionotropic gelation. Parameters for floatability, drug load, encapsulation efficiency, bead morpholo...
Cornus mas L. extract as a multifunctional material for manufacturing cosmetic emulsions [0.03%]
Cornus mas L.提取物作为制备化妆品乳液的多功能材料
Z Nizioł-Łukaszewska,T Wasilewski,T Bujak et al.
Z Nizioł-Łukaszewska et al.
Dogwood fruits are a valuable source of active ingredients, such as phenolic compounds, vitamin C, iridoids, flavonoids and anthocyanins. Plant extracts and substances derived from latin Cornus mas L. exhibit not only strong antibacterial b...
Metabolic profiling of endogenous bile acids: a novel method to assess hepatoprotective effect of Tanreqing capsule on carbon-tetrachloride-induced liver injury in rats [0.03%]
内源性胆酸代谢轮廓测定：评价痰热清对四氯化碳致小鼠肝损伤保护作用的新型方法学研究
Ying Xu,Ping-Ping Zhong,Yan-Yan Tao
Ying Xu
Tanreqing (TRQ), a traditional Chinese medicine (TCM) formula, can alleviate liver injury and improve liver function. Its pharmacological mechanisms of actions are still unclear due to its complex components and multi-target natures. Metabo...
1H NMR-based metabolomics approach to investigating the renal protective effects of Genipin in diabetic rats [0.03%]
基于~1H NMR代谢组学方法研究 Gardeniaphenol 对糖尿病大鼠肾脏保护作用机制
Jun-Sheng Tian,Lei Zhao,Xiao-Li Shen et al.
Jun-Sheng Tian et al.
Diabetic nephropathy is one of the various complications of diabetes mellitus, affecting patients for lifetime. Earlier studies have revealed that genipin can not only improve diabetes, but also induce cytotoxicity. Therefore, it is not cle...
Constituent and effects of polysaccharides isolated from Sophora moorcroftiana seeds on lifespan, reproduction, stress resistance, and antimicrobial capacity in Caenorhabditis elegans [0.03%]
Sophora莫荷草种子多糖的分离、鉴定及其对秀丽隐杆线虫寿命、生殖、抗逆和抗菌能力的影响
Yuan Zhang,Dan-Yang Mi,Jin Wang et al.
Yuan Zhang et al.
Sophora moorcroftiana (S. moorcroftiana) is an endemic leguminous dwarf shrub in Tibet, China. Decoctions of the seeds have been used in Chinese folk medicine for dephlogistication, detoxication, and infectious diseases. The present study a...
Label-free quantitative proteomics reveals fibrinopeptide B and heparin cofactor II as potential serum biomarkers in respiratory syncytial virus-infected mice treated with Qingfei oral liquid formula [0.03%]
基于定量蛋白质组学的清肺口服液治疗呼吸道合胞病毒感染小鼠血清标志物筛选与验证
Li-Hua Zhou,Jian-Ya Xu,Chen Dai et al.
Li-Hua Zhou et al.
Respiratory syncytial virus (RSV) is a leading cause of acute lower respiratory tract infections. Qingfei oral liquid (QFOL), a traditional Chinese medicine, is widely used in clinical treatment for RSV-induced pneumonia. The present study ...