New flavonoids and methylchromone isolated from the aerial parts of Baeckea frutescens and their inhibitory activities against cyclooxygenases-1 and -2 [0.03%]
Baeckea frutescens的全草中具有环氧合酶抑制活性的黄酮和甲基氢化苯并吡喃酮化合物研究
Jun-Neng Zhou,Ming Yan,Peng Gao et al.
Jun-Neng Zhou et al.
In the present study, we carried out a phytochemical investigation of the ethanol extract of the aerial parts of Baeckea frutescens, which resulted in the isolation of two new flavonoid glycosides, myricetin 3-O-(5″-O-galloyl)-α-L-arabino...
Dan Zhao,Shan-Shan Su,Shao-Fei Chen et al.
Dan Zhao et al.
The present study was designed to further investigate the C21 steroidal glycosides in Cynanchum plants. Two new steroidal glycosides based on a 13, 14:14, 15-disecopregnane-type aglycone, komaroside P (1) and komaroside Q (2), together with...
1-Methoxycarbony-β-carboline from Picrasma quassioides exerts anti-angiogenic properties in HUVECs in vitro and zebrafish embryos in vivo [0.03%]
碎米丸叶藤素甲氧基碳酰茋衍生物的体外体内抗血管生成作用研究
Qing-Hua Lin,Wei Qu,Jian Xu et al.
Qing-Hua Lin et al.
Angiogenesis is a crucial process in the development of inflammatory diseases, including cancer, psoriasis and rheumatoid arthritis. Recently, several alkaloids from Picrasma quassioides had been screened for angiogenic activity in the zebr...
Global gene expression analysis in liver of db/db mice treated with catalpol [0.03%]
催化pis醇治疗db/db小鼠肝脏全基因表达分析
Jing Liu,He-Ran Zhang,Yan-Bao Hou et al.
Jing Liu et al.
Catalpol, a major bioactive component from Rehmannia glutinosa, which has been used to treat diabetes. The present study was designed to elucidate the anti-diabetic effect and mechanism of action for catalpol in db/db mice. The db/db mice w...
Quercetin modulates iron homeostasis and iNOS expression of splenic macrophages in a rat model of iron deficiency anemia [0.03%]
檞皮素对缺铁性贫血大鼠脾脏巨噬细胞铁稳态及iNOS表达的调节作用
Maryam Mazhar,Nurul Kabir,Shabana U Simjee
Maryam Mazhar
Iron deficiency anemia is one of the most common micronutrient deficient conditions around the globe with various consequences, including the weakened immune system. Quercetin is widely distributed bioflavonoid; it has been debated for its ...
Hypolipidemic effect of SIPI-7623, a derivative of an extract from oriental wormwood, through farnesoid X receptor antagonism [0.03%]
异环阿魏酸通过法尼酯X受体拮抗作用发挥降脂效果：SIPI-7623的研究
Yi-Fang Deng,Xiao-Ling Huang,Mei Su et al.
Yi-Fang Deng et al.
Farnesoid X receptor (FXR) is a member of the nuclear receptor superfamily of ligand-activated transcription factors. As a metabolic regulator, FXR plays key roles in bile acid and cholesterol metabolism and lipid and glucose homeostasis. T...
Application of alkaloids in reversing multidrug resistance in human cancers [0.03%]
生物碱逆转人类肿瘤多药耐药性的应用研究进展
Meng Wang,Ze-Fa Liu,Hua Tang et al.
Meng Wang et al.
Multidrug resistance (MDR) in human cancer is one of greatest challenges in cancer therapy. Natural products, especially the alkaloids, exert reversed effects on MDR with low toxicity, by interacting with various targets. In this review art...
Identification and screening of cardiac glycosides in Streptocaulon griffithii using an integrated data mining strategy based on high resolution mass spectrometry [0.03%]
基于高分辨率质谱的集成数据挖掘策略在Streptocaulon griffithii中识别和筛选强心苷类化合物
Xiao-Yu Zhu,Jia-Zhuo Liu,Zhen-Huan Dong et al.
Xiao-Yu Zhu et al.
The present study was designed to develop a practical strategy to tackle the problem of lacking standard compounds and limited references for identifying structure-related compounds in Streptocaulon griffithii Hook. f., especially those in ...
Identification and characterization of major constituents in Juglans mandshurica using ultra performance liquid chromatography coupled with time-of-flight mass spectrometry (UPLC-ESI-Q-TOF/MS) [0.03%]
采用超高效液相色谱与四极杆-飞行时间质谱联用技术（UPLC-ESI-Q-TOF/MS）鉴定并分析辽 walnut 的化学成分
Jin-Hai Huo,Xiao-Wei DU,Guo-Dong Sun et al.
Jin-Hai Huo et al.
The present study was designed to identify and characterize the major constituents in Juglans mandshurica Maxim. A simple, efficient and sensitive ultra performance liquid chromatography coupled with time-of-flight mass spectrometry (UPLC-E...
Identification of active compound combination contributing to anti-inflammatory activity of Xiao-Cheng-Qi Decoction via human intestinal bacterial metabolism [0.03%]
基于人体肠道菌群代谢的小承气汤抗炎有效物质对群的识别
Xing-Yan Liu,Li Li,Xue-Qing Li et al.
Xing-Yan Liu et al.
Human intestinal bacteria play an important role in the metabolism of herbal medicines, leading to the variations in their pharmacological profile. The present study aimed to investigate the metabolism of Xiao-Cheng-Qi decoction (XCQD) by h...