Protective effects of extracts of Schisandra chinensis stems against acetaminophen-induced hepatotoxicity via regulation of MAPK and caspase-3 signaling pathways [0.03%]
五味子茎提取物通过调节MAPK和Caspase-3信号通路对乙酰氨基酚致肝毒性的保护作用
Yan-Zi Li,Zhi-Na Ma,Yin-Shi Sun et al.
Yan-Zi Li et al.
The present study was designed to evaluate protective activity of an ethanol extract of the stems of Schisandra chinensis (SCE) and explore its possible molecular mechanisms on acetaminophen (APAP) induced hepatotoxicity in a mouse model. T...
Gambogic acid induces cell apoptosis through endoplasmic reticulum stress triggered inhibition of Akt signaling pathways in extranodal NK/T-cell lymphoma cells [0.03%]
gambogic酸通过内质网压力诱导抑制Akt信号途径在结外自然杀伤细胞/T细胞淋巴瘤细胞中的凋亡作用
Wei Peng,Bao-An Chen
Wei Peng
As the chemotherapeutic resistance of extranodal NK/T-cell lymphoma (ENKTL) rises year by year, searching for novel chemoprevention compounds has become imminent. Gambogic acid (GA) has recently been shown to have anti-tumor effects, but it...
Discovery of synergistic anti-inflammatory compound combination from herbal formula GuGe FengTong Tablet [0.03%]
从喉症丸中发现协同抑制炎症的药对组合
Le-Le Liu,Qun Liu,Ping Li et al.
Le-Le Liu et al.
Multi-components in herbal formulae exert holistic effects in synergistic or additive manners. However, appropriate strategies and supportive evidences are still lacking to uncover the synergistic or additive combinations. The present inves...
Polysaccharide extracts of Astragalus membranaceus and Atractylodes macrocephala promote intestinal epithelial cell migration by activating the polyamine-mediated K+ channel [0.03%]
膜荚黄芪和大戟属Macrocephala多糖提取物通过激活聚胺介导的钾通道促进肠上皮细胞迁移
Dan Zeng,Can Hu,Ru-Liu Li et al.
Dan Zeng et al.
Astragalus membranaceus (Radix Astragali, RA) and Atractylodes macrocephala (Rhizoma Atractylodis Macrocephalae, RAM) are often used to treat gastrointestinal diseases. In the present study, we determined the effects of polysaccharides extr...
Anti-parasitic effects of water-soluble alkaloid fractions from ethanolic extracts of Sophora moorcroftiana seeds in Caenorhabditis elegans [0.03%]
苦哇拉藤种子乙醇提取物水溶性生物碱组分抗虫活性研究
Yan-Ping Luo,Yuan Zhang,Hui-Min Zhang et al.
Yan-Ping Luo et al.
Parasite infections of humans and animals remain a major global health problem, with limited choice of drugs being available to the treatment of parasitosis in the clinic. Sophora moorcroftiana (S. moorcroftiana) is a shrub that grows in Ti...
Xin-Zhi Wang,Shen-Ye Zhang,Yao Xu et al.
Xin-Zhi Wang et al.
Triptolide (TP) induces severe liver injury, but its hepatotoxicity mechanisms are still unclear. Inflammatory responses may be involved in the pathophysiology. Neutrophils are the first-line immune effectors for sterile and non-sterile inf...
Stems and leaves of Aconitum carmichaelii Debx. as potential herbal resources for treating rheumatoid arthritis: Chemical analysis, toxicity and activity evaluation [0.03%]
毛果防己药材的根茎叶资源再利用：化学分析、毒性及药效评价
Ya-Nan He,Shui-Ping Ou,Xi Xiong et al.
Ya-Nan He et al.
According to folk usage of Aconitum carmichaelii Debx., the present study was designed to determine the feasibility of the stems and leaves of Aconitum carmichaelii Debx. as a new medicinal resource. Fourteen alkaloids in mother roots, fibr...
Anticancer activity and underlying mechanism of neogambogic acid [0.03%]
新生 gambogic 酸的抗肿瘤活性及其作用机制研究
Rui Sun,Hong-Ming Zhang,Bao-An Chen
Rui Sun
Garcinia, a kind of dry resin secreted by Garcinia hanburyi Hook. F. G., is a traditional Chinese medicine with various biological functions such as detoxification, anti-inflammatory, and anthelmintic activities. Recent studies suggest that...
Metabonomics delineates allergic reactions induced by Shuang-huang-lian injection in rats using ultra performance liquid chromatography-mass spectrometry [0.03%]
基于UPLC-MS的代谢组学方法研究双黄连注射液引起的大鼠过敏反应
Yuan-Yuan Gu,Lang Shi,Dan-Dan Zhang et al.
Yuan-Yuan Gu et al.
Shuang-huang-lian Injection (SHLI) is the first successfully developed drug from traditional Chinese medicine (TCM) powder for injection, since its use for the treatment of acute respiratory tract infection, pneumonia, influenza, etc. At th...
Novel sesquiterpenoids isolated from Chimonanthus praecox and their antibacterial activities [0.03%]
冬青属植物的新型倍半萜及其抗菌活性研究
Hua-Yong Lou,Yu Zhang,Xiao-Pan Ma et al.
Hua-Yong Lou et al.
In the present study, four new sesquiterpenoids, chimonols A-D (compounds 1-4), together with four known compounds (5-8) were isolated from the EtOAc extract of Chimonanthus praecox Link. The structures of these new compounds were elucidate...