The CXCL12 (SDF-1)/CXCR4 chemokine axis: Oncogenic properties, molecular targeting, and synthetic and natural product CXCR4 inhibitors for cancer therapy [0.03%]
趋化因子cxcl12（sdf-1）/cxcr4轴：致癌特性，分子靶向以及癌症治疗的cxcr4抑制剂（合成和天然产物）
Yu Zhou,Han-Bo Cao,Wen-Jun Li et al.
Yu Zhou et al.
Chemokine 12 (CXCL12), also known as stromal cell derived factor-1 (SDF-1) and a member of the CXC chemokine subfamily, is ubiquitously expressed in many tissues and cell types. It interacts specifically with the ligand for the transmembran...
Profiling and identification of chemical components of Shenshao Tablet and its absorbed components in rats by comprehensive HPLC/DAD/ESI-MSn analysis [0.03%]
高效液相色谱/二极管阵列检测器/串联质谱联用技术综合解析神效救心丸的化学成分及其在大鼠体内的吸收成分
Wen-Juan Miao,Ying Hu,Li Jia et al.
Wen-Juan Miao et al.
Shenshao Tablet (SST), prepared from Paeoniae Radix Alba (PRA) and total ginsenoside of Ginseng Stems and Leaves (GSL), is a traditional Chinese medicine (TCM) preparation prescribed to treat coronary heart disease. However, its chemical co...
Design, synthesis, and biological evaluation of novel nitric oxide releasing dehydroandrographolide derivatives [0.03%]
新型硝酸盐释放去氢苦参素衍生物的设计、合成及生物活性评价
Lin Yan,Yu-Xuan Dai,Guo-Long Gu et al.
Lin Yan et al.
A series of new hybrids of dehydroandrographolide (TAD), a biologically active natural product, bearing nitric oxide (NO)-releasing moieties were synthesized and designated as NO-donor dehydroandrographolide. The biological activities of ta...
Novel berberine derivatives: Design, synthesis, antimicrobial effects, and molecular docking studies [0.03%]
新小檗碱衍生物的研究：设计、合成、抗菌作用及分子对接研究
Ling Yao,Ling-Ling Wu,Qian Li et al.
Ling Yao et al.
A series of berberine derivatives were synthesized by introducing substituted benzyl groups at C-9. All these synthesized compounds (4a-4m) were screened for their in vitro antibacterial activity against four Gram-positive bacteria and four...
Effects of six compounds with different chemical structures on melanogenesis [0.03%]
六种不同化学结构的化合物对黑色素生成的影响
Rakotomalala Manda Heriniaina,Jing Dong,Praveen Kumar Kalavagunta et al.
Rakotomalala Manda Heriniaina et al.
Several chemical compounds can restore pigmentation in vitiligo through mechanisms that vary according to disease etiology. In the present study, we investigated the melanogenic activity of six structurally distinct compounds, namely, scopo...
Systems pharmacology-based investigation of Sanwei Ganjiang Prescription: related mechanisms in liver injury [0.03%]
基于系统药理学的三方干姜汤的肝损伤相关机制研究
Yun-Xia Luo,Xin-Yue Wang,Yu-Jie Huang et al.
Yun-Xia Luo et al.
Liver injury remains a significant global health problem and has a variety of causes, including oxidative stress (OS), inflammation, and apoptosis of liver cells. There is currently no curative therapy for this disorder. Sanwei Ganjiang Pre...
Discovery of differential sequences for improving breeding and yield of cultivated Ophiocordyceps sinensis through ITS sequencing and phylogenetic analysis [0.03%]
基于ITS测序和系统发育分析的冬虫夏草栽培品差异序列发掘及功能验证研究
Qi-Qing Cheng,Chun-Song Cheng,Yue Ouyang et al.
Qi-Qing Cheng et al.
To accelerate the breeding process of cultivated Ophiocordyceps sinensis and increase its yield, it is important to identify molecular fingerprint of dominant O. sinensis. In the present study, we collected 3 batches of industrially cultiva...
Advances in the antitumor activities and mechanisms of action of steroidal saponins [0.03%]
甾体皂苷抗肿瘤活性及作用机制研究进展
Ya-Zheng Zhao,Yuan-Yuan Zhang,Han Han et al.
Ya-Zheng Zhao et al.
The steroidal saponins are one of the saponin types that exist in an unbound state and have various pharmacological activities, such as anticancer, anti-inflammatory, antiviral, antibacterial and nerves-calming properties. Cancer is a growi...
Ethnopharmacology, phytochemistry, and pharmacology of Sterculia lychnophora Hance (Pangdahai) [0.03%]
Sterculia lychnophora Hance（胖大海）的民族药理学、植物化学及药理学研究进展
Mahmood Brobbey Oppong,Yang Li,Prince Osei Banahene et al.
Mahmood Brobbey Oppong et al.
The matured, ripen, and dried seeds of Scaphium affine (Mast.) Pierre, known as Pangdahai (PDH) in Chinese and recorded as Sterculia lychnophora Hance (scientific synonym) in the 2015 edition of the Chinese Pharmacopeia, have been widely us...
Metabolomics analysis and rapid identification of changes in chemical ingredients in crude and processed Astragali Radix by UPLC-QTOF-MS combined with novel informatics UNIFI platform [0.03%]
基于UPLC-QTOF-MS结合UNIFI信息平台的代谢组学分析及黄芪与炙黄芪化学成分变化的快速识别研究
Peng-Peng Liu,Guo-Shun Shan,Fan Zhang et al.
Peng-Peng Liu et al.
Astragali Radix, the root of Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao or Astragalus membranaceus (Fisch.) Bge., is widely used as a tonic decoction pieces in the clinic of traditional Chinese medicine (TCM). Astra...