Evaluation of neuroactive effects of ethanol extract of Schisandra chinensis, Schisandrin, and Schisandrin B and determination of underlying mechanisms by zebrafish behavioral profiling [0.03%]
基于斑马鱼行为图谱的五味子乙醇提取物、Schisandrin和Schisandrin B的神经活性评价及其作用机制研究
Jia-Wei Wang,Feng-Yin Liang,Xiang-Shuo Ouyang et al.
Jia-Wei Wang et al.
Schisandra chinensis, a traditional Chinese medicine (TCM), has been used to treat sleep disorders. Zebrafish sleep/wake behavioral profiling provides a high-throughput platform to screen chemicals, but has never been used to study extracts...
Carnosic acid enhances the anti-lung cancer effect of cisplatin by inhibiting myeloid-derived suppressor cells [0.03%]
岩藻酸增强岩藻糖对肺癌症的抑制通过抑制髓样衍生抑制细胞功效
Wen Liu,Tian-Cong Wu,Dong-Mei Hong et al.
Wen Liu et al.
Cisplatin and other platinum-based drugs are used frequently for treatment of lung cancer. However, their clinical performance are usually limited by drug resistance or toxic effects. Carnosic acid, a polyphenolic diterpene isolated from Ro...
Advanced natural products chemistry research in China between 2015 and 2017 [0.03%]
中国天然产物化学的近期研究进展(2015-2017)
Guo-Xun Yang,Guang-Lei Ma,Hao Li et al.
Guo-Xun Yang et al.
In this review, we intensively focus on the advances in research of natural products (NPs) discovery carried out by domestic scholars in China from 2015 through 2017. In general, a total of 1811 publications (1479 in English and 332 in Chin...
Identification of poliumoside metabolites in rat plasma, urine, bile, and intestinal bacteria with UPLC/Q-TOF-MS [0.03%]
超高效液相色谱/四极杆飞行时间质谱法分析毛蕊花糖苷在大鼠血浆、尿液、胆汁和肠道菌群中的代谢产物
Hao Qian,Fang-Jun Yu,Dan-Yi Lu et al.
Hao Qian et al.
Poliumoside is representative of phenylethanoid glycosides, which are widely found in many plants. Poliumoside is also regarded as the main active component of Callicarpa kwangtungensis Chun (CK), though its oral bioavailability in rat is e...
Yan Shu,Tian-Peng Yin,Jia-Peng Wang et al.
Yan Shu et al.
In the present study, three new aconitine-type diterpenoid alkaloids brochyponines A-C (1-3) were isolated from the roots of Aconitum brevicalcaratum. Their structures were established on the basis of extensive spectroscopic analyses (IR, H...
Ursane derivatives isolated from leaves of Hylocereus undatus inhibit glycation at multiple stages [0.03%]
乙型肝炎病毒核心抗原的水解肽抑制剂诱导树突状细胞产生免疫应答
Pérez-Gutiérrez Rosa Martha,Enriquez-Alvirde Susana Gabriela
Pérez-Gutiérrez Rosa Martha
The present study was designed to evaluate the therapeutic potential of bioactive compounds from chloroform extract of the leaves of Hylocereus undatus in the formation of advanced glycation end products (AGEs) in vitro. Bioactivity-guided ...
Sodium tanshinone IIA sulfonate attenuates cardiac dysfunction and improves survival of rats with cecal ligation and puncture-induced sepsis [0.03%]
丹参酮 ⅡA 磺酸钠改善盲肠结扎穿孔诱导的脓毒症大鼠心脏功能及提高生存率
Zheng-Jie Meng,Chao Wang,Ling-Tong Meng et al.
Zheng-Jie Meng et al.
Cardiac dysfunction, a common consequence of sepsis, is the major contribution to morbidity and mortality in patients. Sodium tanshinone IIA sulfonate (STS) is a water-soluble derivative of Tanshinone IIA (TA), a main active component of Sa...
Salvianolic acids improve liver lipid metabolism in ovariectomized rats via blocking STAT-3/SREBP1 signaling [0.03%]
鼠李糖芸香苷通过抑制STAT-3/SREBP1信号通路改善卵巢切除大鼠肝脏脂代谢紊乱的作用研究
Juan Chen,Jia Yue,Jiao Liu et al.
Juan Chen et al.
Postmenopausal women, who have reduced circulating estrogen levels, are more prone to develop obesity and related metabolic diseases than premenopausal women. The absence of safe and effective treatments for postmenopausal obesity has chang...
Qing-Qing Yao,Li Li,Ming-Cheng Xu et al.
Qing-Qing Yao et al.
Pharmacological activities and adverse side effects of ginkgolic acids (GAs), major components in extracts from the leaves and seed coats of Ginkgo biloba L, have been intensively studied. However, there are few reports on their hepatotoxic...
Ben-Mei Zhang,Zhi-Bin Wang,Ping Xin et al.
Ben-Mei Zhang et al.
The genus Ephedra of the Ephedraceae family contains more than 60 species of nonflowering seed plants distributed throughout Asia, America, Europe, and North Africa. These Ephedra species have medicinal, ecological, and economic value. This...