Anti-cancer and anti-inflammatory effects of flavan-4-ol and flavan glycosides from the roots of Pronephrium penangianum [0.03%]
Pronephrium penangianum根中黄烷-4-醇和黄烷糖苷的抗肿瘤及抗炎作用
Feibing Huang,Yong Yang,Qingling Xie et al.
Feibing Huang et al.
Five new flavan-4-ol glycosides jixueqiosides A-E (1-5) and two new flavan glycosides jixueqiosides F and G (6 and 7), along with twelve known flavan-4-ol glycosides (8-19), were isolated from the roots of Pronephrium penangianum. Comprehen...
Pristimerin induces Noxa-dependent apoptosis by activating the FoxO3a pathway in esophageal squamous cell carcinoma [0.03%]
白桦脂素通过激活FoxO3a通路诱导Noxa依赖性凋亡在食管鳞状细胞癌中的作用
Mengyuan Feng,Anjie Zhang,Jingyi Wu et al.
Mengyuan Feng et al.
Pristimerin, which is one of the compounds present in Celastraceae and Hippocrateaceae, has antitumor effects. However, its mechanism of action in esophageal squamous cell carcinoma (ESCC) remains unclear. This study aims to investigate the...
Salidroside inhibits osteoclast differentiation based on osteoblast-osteoclast interaction via HIF-1a pathway [0.03%]
红景天苷通过骨细胞-破骨细胞相互作用的HIF-1α通路抑制破骨细胞分化
Yutong Jin,Yao Wang,Chuan Wang et al.
Yutong Jin et al.
This study investigated the regulatory potential of salidroside (SAL), a primary active compound in Rhodiola rosea L., on osteoclast differentiation by modulating the hypoxia-inducible factor 1-alpha (HIF-1a) pathway in osteoblasts. Lucifer...
Lingguizhugan Decoction improves chronic heart failure by synergistically modulating ?1-AR/Gs/GRKs/?-arrestin signaling bias [0.03%]
苓桂术甘汤通过协同调节偏置信号通路改善慢性心力衰竭
Shuting Guo,Lei Xia,Songru Yang et al.
Shuting Guo et al.
Lingguizhugan Decoction (LGZG) demonstrates significant efficacy in treating various cardiovascular diseases clinically, yet its precise mechanism of action remains elusive. This study aimed to elucidate the potential mechanisms and effects...
Progress on the functions and mechanisms of natural products in anti-glioma therapy [0.03%]
天然产物抗胶质瘤功效及机制研究进展
Yanting Li,Shuhui Qu,Jiayi Zuo et al.
Yanting Li et al.
Glioma, the most prevalent primary tumor of the central nervous system (CNS), is also the most lethal primary malignant tumor. Currently, there are limited chemotherapeutics available for glioma treatment, necessitating further research to ...
Research advances in the treatment of arthritis from natural products (2014-present) [0.03%]
2014年以来基于天然产物治疗关节炎的研究进展
Ruilin Wang,Cen Ji,Jiayao Chen et al.
Ruilin Wang et al.
Arthritis, encompassing osteoarthritis (OA), rheumatoid arthritis (RA), and gouty arthritis (GA), is a prevalent inflammatory disease that significantly impacts quality of life. Natural products (NPs), derived from animals, plants, marine o...
Structurally diverse sesquiterpenoids with anti-MDR cancer activity from Penicillium roqueforti [0.03%]
罗轮青霉菌中抗多药耐药性癌活性的倍半萜类化合物
Shuyuan Mo,Nanjin Ding,Zhihong Huang et al.
Shuyuan Mo et al.
Five novel nor-eremophilane-type sesquiterpenoids, peniroqueforins E-H and J (1-4 and 7), two new eremophilane-type sesquiterpenoids, peniroqueforins I and K (5 and 8), and a new eudesmane-type sesquiterpenoid, peniroqueforin L (9), along w...
Novel araucarene diterpenes from Agathis dammara exert hypoglycemic activity by promoting pancreatic β cell regeneration and glucose uptake [0.03%]
降糖新木脂素类化合物促进胰岛β细胞新生和葡萄糖摄取研究进展
Zhewei Yu,Yi Zhang,Wenhui Wang et al.
Zhewei Yu et al.
In this study, araucarene diterpenes, characterized by a pimarene skeleton with a variably oxidized side chain at C-13, were investigated. A total of 16 araucarene diterpenoids and their derivatives were isolated from the woods of Agathis d...
Andrographolide sulfonate alleviates rheumatoid arthritis by inhibiting glycolysis-mediated activation of PI3K/AKT to restrain Th17 cell differentiation [0.03%]
安卡前列素通过抑制糖酵解介导的PI3K / AKT活化来缓解类风湿性关节炎以抑制Th17细胞分化
Chunhong Jiang,Xi Zeng,Jia Wang et al.
Chunhong Jiang et al.
Andrographolide sulfonate (AS) is a sulfonated derivative of andrographolide extracted from Andrographis paniculata (Burm.f.) Nees, and has been approved for several decades in China. The present study aimed to investigate the novel therape...
Shionone protects cerebral ischemic injury through alleviating microglia-mediated neuroinflammation [0.03%]
石杉叶醇通过减轻小胶质细胞介导的神经炎症来保护缺血性脑损伤
Lushan Xu,Chenggang Li,ChenChen Zhao et al.
Lushan Xu et al.
Microglia, the resident immune cells in the central nervous system (CNS), rapidly transition from a resting to an active state in the acute phase of ischemic brain injury. This active state mediates a pro-inflammatory response that can exac...