Involvement of mitochondrial apoptotic pathway and MAPKs/NF-κ B inflammatory pathway in the neuroprotective effect of atractylenolide III in corticosterone-induced PC12 cells [0.03%]
白术内酯III通过线粒体凋亡通路和MAPKs/NF-κB炎症通路发挥糖皮质激素诱导的PC12细胞神经保护作用
Wen-Xia Gong,Yu-Zhi Zhou,Xue-Mei Qin et al.
Wen-Xia Gong et al.
Atractylenolide III (ATL-III), a sesquiterpene compound isolated from Rhizoma Atractylodis Macrocephalae, has revealed a number of pharmacological properties including anti-inflammatory, anti-cancer activity, and neuroprotective effect. Thi...
Astragalus membranaceus improves therapeutic efficacy of asthmatic children by regulating the balance of Treg/Th17 cells [0.03%]
膜荚黄芪通过调节哮喘患儿Treg/Th17细胞平衡提高临床疗效
Wei Wang,Qing-Bin Liu,Wei Jing
Wei Wang
Astragalus membranaceus may be a potential therapy for childhood asthma but its driving mechanism remains elusive. The main components of A. membranaceus were identified by HPLC. The children with asthma remission were divided into two comb...
Zhao-He Li,You Zhou,You-Xiang Ding et al.
Zhao-He Li et al.
Integrin is a large family of cell adhesion molecules (CAMs) which involves in the interaction of cells/cells and cells/ extracellular matrix (ECM) to mediate cell proliferation, differentiation, adhesion, migration, etc. In recent years, a...
Quantification of Panax notoginseng saponins metabolites in rat plasma with in vivo gut microbiota-mediated biotransformation by HPLC-MS/MS [0.03%]
含肠道微生物的体内样品中止血活性皂苷代谢产物的HPLC-MS/MS测定方法
Yin-Ping Guo,Man-Yun Chen,Li Shao et al.
Yin-Ping Guo et al.
Panax notoginseng saponins (PNS) are the major components of Panax notoginseng, with multiple pharmacological activities but poor oral bioavailability. PNS could be metabolized by gut microbiota in vitro, while the exact role of gut microbi...
Two new nimbolinin- and trichilin-class limonoids isolated from the fruits of Melia azedarach [0.03%]
Melia属植物中国晴的果实中新纳木宾和三氯林类衍生物的研究
Lu Qiu,Li Heng,Rong Xu et al.
Lu Qiu et al.
Two new furan fragment isomerized limonoids, meliazedalides A and B (compounds 1 and 2), were isolated from the fruits of Melia azedarach Linn.. Their chemical structures were elucidated on the basis of HR-ESI-MS and 1D and 2D NMR data, whi...
Lower clearance of sodium tanshinone IIA sulfonate in coronary heart disease patients and the effect of total bilirubin: a population pharmacokinetics analysis [0.03%]
冠心病患者红花黄色素钠清除率降低及其胆红素水平影响的群体药代动力学分析
Wei-Wei Qin,Li Wang,Zheng Jiao et al.
Wei-Wei Qin et al.
This study developed a population pharmacokinetic model for sodium tanshinone IIA sulfonate (STS) in healthy volunteers and coronary heart disease (CHD) patients in order to identify significant covariates for the pharmacokinetics of STS. B...
Two natural molecules preferentially inhibit azole-resistant Candida albicans with MDR1 hyperactivation [0.03%]
两种天然分子能够优先抑制MDR1高表达的伏立康唑耐药白念珠菌株
Hong-Zhuo Shi,Wen-Qiang Chang,Ming Zhang et al.
Hong-Zhuo Shi et al.
Antifungal drug resistance is a significant clinical problem, and antifungal agents that can evade resistance are urgently needed. In infective niches, resistant organisms often co-existed with sensitive ones, or a subpopulation of antibiot...
The Zuo Jin Wan Formula increases chemosensitivity of human primary gastric cancer cells by AKT mediated mitochondrial translocation of cofilin-1 [0.03%]
左金丸通过AKT介导的线粒体科菲林-1转位增强人胃癌原代细胞化疗敏感性
Meng-Yao Sun,Dan-Dan Wang,Jian Sun et al.
Meng-Yao Sun et al.
Resistance to cisplatin (DDP)-based chemotherapy is a major cause of treatment failure in human gastric cancer (GC). It is necessary to identify the drugs to re-sensitize GC cells to DDP. In our previous research, Zuo Jin Wan Formula (ZJW) ...
Houttuynia cordata polysaccharide alleviated intestinal injury and modulated intestinal microbiota in H1N1 virus infected mice [0.03%]
Houttuynia cordata多糖通过改善肠道屏障功能和调节肠道菌群结构治疗甲型流感病毒感染小鼠肠道损伤的作用研究
Mei-Yu Chen,Hong Li,Xiao-Xiao Lu et al.
Mei-Yu Chen et al.
Houttuynia cordata polysaccharide (HCP) is extracted from Houttuynia cordata, a key traditional Chinese medicine. The study was to investigate the effects of HCP on intestinal barrier and microbiota in H1N1 virus infected mice. Mice were in...
Ren-Geng Shu,Yi-Li Wan,Xiao-Min Wang
Ren-Geng Shu
Chimonanthus plants widely distributed in southern area of China, which have a long history of edibles and medicine. Phytochemical investigations have shown that Chimonanthus produced 143 non-volatile constituents, including alkaloids, flav...