Vitellaria paradoxa nutshells from seven sub-Saharan countries as potential herbal medicines for treating diabetes based on chemical compositions, HPLC fingerprints and bioactivity evaluation [0.03%]
基于化学成分、HPLC指纹图谱和生物活性评价的七国西非荔枝核作为治疗糖尿病的潜在草药
Da Li,Jian-Qi Xiao,Wen-Yuan Liu et al.
Da Li et al.
The aim of the study was to determine the feasibility of the Vitellaria paradoxa nutshell as a new medicinal resource for treating diabetes. A total of forty-one compounds were identified by HPLC-DAD-Q-TOF-MS and phytochemical methods in V....
Cimicifuga heracleifolia is therapeutically similar to black cohosh in relieving menopausal symptoms: evidence from pharmacological and metabolomics studies [0.03%]
益母草流浸膏可能通过改善糖脂代谢及内皮功能治疗绝经期综合征：药理及代谢组学研究证据
Lan-Yun Miao,Thi Thanh Huyen Chu,Ping Li et al.
Lan-Yun Miao et al.
In the market of botanical dietary supplements, Cimicifuga heracleifolia (CH) has always been considered as an adulterated species of Cimicifuga racemosa (CR), a conventional American herb with promising benefits to counteract troubles aris...
Pretreatment of Populus tomentiglandulosa protects hippocampal CA1 pyramidal neurons from ischemia-reperfusion injury in gerbils via increasing SODs expressions and maintaining BDNF and IGF-I expressions [0.03%]
毛腺虎榛子杨预处理通过提高SODs表达及维持BDNF和IGF-I的表达保护沙鼠海马CA1锥体神经元免受缺血再灌注损伤
Tae-Kyeong Lee,Joon Ha Park,Ji Hyeon Ahn et al.
Tae-Kyeong Lee et al.
To examine the effects of Populus tomentiglandulosa (PT) extract on the expressions of antioxidant enzymes and neurotrophic factors in the cornu ammonis 1 (CA1) region of the hippocampus at 5 min after inducing transient global cerebral isc...
3'-Methoxydaidzein exerts analgesic activity by inhibiting voltage-gated sodium channels [0.03%]
3-甲氧基大豆苷元通过抑制电压门控钠离子通道产生镇痛作用
Run-Jia Xu,Shuo-Han Fei,Lin-Yan Chen et al.
Run-Jia Xu et al.
Isoflavones are widely consumed by people around the world in the form of soy products, dietary supplements and drugs. Many isoflavones or related crude extracts have been reported to exert pain-relief activities, but the mechanism remains ...
The mechanisms of traditional Chinese medicine underlying the prevention and treatment of atherosclerosis [0.03%]
中医药防治动脉粥样硬化的机制研究进展
Ting-Ting Li,Zhi-Bin Wang,Yang Li et al.
Ting-Ting Li et al.
Atherosclerosis (AS) is a chronic inflammatory disease associated with high morbidity and mortality. The incidence of AS is increasing in the last decades. So development of safe and effective therapeutics for treating AS has become promine...
Bing-Yu Liu,Fei Xu,Jian Bai et al.
Bing-Yu Liu et al.
Six novel monacolin analogs, monacolins V1-V6 (1-6), together with seven known ones (7-13), were isolated from the ethyl acetate extract of red yeast rice. Their structures and absolute configurations were determined by spectroscopic method...
Dalestones A and B, two anti-inflammatory cyclopentenones from Daldinia eschscholzii with an edited strong promoter for the global regulator LaeA-like gene [0.03%]
来自Daldinia eschscholzii的两个抗炎环戊烯酮 Dalestones A和B及其用于编辑LaeA-like基因高效启动子的工具
Zhen-Zhen Zhou,Hong-Jie Zhu,Cheng-Long Yang et al.
Zhen-Zhen Zhou et al.
Replacement of the native promoter of theglobal regulator LaeA-like gene of Daldinia eschscholzii by a strong gpdA promoter led to the generation of two novel cyclopentenone metabolites, named dalestones A and B, whose structures were assig...
Prenylated stilbenes and flavonoids from the leaves of Cajanus cajan [0.03%]
Cajanus cajan叶子中的牻牛儿基茋和黄酮类化合物
Gui-Yun Wu,Xiao Zhang,Xue-Ying Guo et al.
Gui-Yun Wu et al.
Three new prenylated stilbenes, named as cajanusins A-C (1-3), and one new natural product cajanusin D (4), along with six known derivatives (5-10) were isolated from the leaves of Cajanus cajan. Their structures were fully elucidated by me...
Broussonin E suppresses LPS-induced inflammatory response in macrophages via inhibiting MAPK pathway and enhancing JAK2-STAT3 pathway [0.03%]
白芥素E通过抑制MAPK途径和增强JAK2-STAT3信号通路抑制LPS诱导的巨噬细胞炎症反应
Shao-Peng Huang,Xin Guan,Guo-Yin Kai et al.
Shao-Peng Huang et al.
Macrophages play an important role in inflammation, and excessive and chronic activation of macrophages leads to systemic inflammatory diseases, such as atherosclerosis and rheumatoid arthritis. In this paper, we explored the anti-inflammat...
5, 7, 2', 4', 5'-Pentamethoxyflavanone regulates M1/M2 macrophage phenotype and protects the septic mice [0.03%]
5, 7, 2', 4', 5'-五甲氧基黄烷酮通过调节M1/M2型巨噬细胞极化保护脓毒症小鼠模型
Li-Li Feng,Li-Sha Xu,Meng-Meng Guo et al.
Li-Li Feng et al.
Flavonoids have been reported to exert protective effect against many inflammatory diseases, while the underlying cellular mechanisms are still not completely known. In the present study, we explored the anti-inflammation activity of 5, 7, ...