Traditional Chinese medicine extraction method by ethanol delivers drug-like molecules [0.03%]
乙醇提取传统中药可得药物分子
William G Miao,Chunping Tang,Yang Ye et al.
William G Miao et al.
Traditional Chinese Medicine (TCM) is an important reservoir for bioactive natural products. TCM extraction methods by water decoction and wine tincture are an integral part of TCM and essential for their widely acknowledged efficacy. In th...
3, 4-seco-Labdane diterpenoids from the leaves of Callicarpa nudiflora with anti-inflammatory effects [0.03%]
具有抗炎活性的Callicarpa nudiflora叶子中3,4-秒LABDANE二萜类化合物
Hong-Gang Wang,Fu-Kang Luo,Xiang Lei et al.
Hong-Gang Wang et al.
Four new 3, 4-seco-labdane diterpenoids, nudiflopenes J-M, were isolated from the leaves of Callicarpa nudiflora along with six known compounds. The structures of these diterpenoids were determined by comprehensive spectroscopic analysis. A...
New aporphine alkaloids with selective cytotoxicity against glioma stem cells from Thalictrum foetidum [0.03%]
Thalictrum foetidum中具有胶质瘤干细胞选择性细胞毒性的新原阿朴菲生物碱
Cai-Feng Ding,Zhi Dai,Hao-Fei Yu et al.
Cai-Feng Ding et al.
Seven new isoquinoline alkaloids, 9-(2'-formyl-5', 6'-dimethoxyphenoxy)-1, 2, 3, 10-tetramethoxy dehydroaporphine (1), 9-(2'-formyl-5', 6'-dimethoxyphenoxy)-1, 2, 3, 10-tetramethoxy oxoaporphine (2), 3-methoxy-2'-formyl oxohernandalin (3), ...
Role of kaempferol to increase bioavailability and pharmacokinetics of nifedipine in rats [0.03%]
kaempferol对增加大鼠硝苯地平生物利用度和药动学的作用研究
Ji-Won Park,Jin-Seok Choi
Ji-Won Park
Herein, the purpose of this study is to evaluate the effects of kaempferol on bioavailability and pharmacokinetics of nifedipine and its metabolite dehydronifedipine in rats. The experimental design is based on with or without kaempferol in...
The inhibition mechanism of the uptake of lamivudine via human organic anion transporter 1 by Stellera chamaejasme L. extracts [0.03%]
Stellera chamaejasmeL.提取物通过人有机阴离子转运体1抑制拉米夫定摄取的机理研究
Lan-Ying Pan,Kui Zeng,Li Li et al.
Lan-Ying Pan et al.
Stellera chamaejasme L. is a traditional Chinese medicine with a long history to treat stubborn skin ulcer, and it also has antiviral and antitumor effects. Neochamaejasmine B (NCB), Neochamaejasmine A (NCA) and Chamaechromone (CMC) are the...
Potential hepatic and renal toxicity induced by the biflavonoids from Ginkgo biloba [0.03%]
银杏双黄酮引起的潜在肝肾毒性
Yun-Ying Li,Xiao-Yan Lu,Jia-Li Sun et al.
Yun-Ying Li et al.
Evidence continues to grow on potential health risks associated with Ginkgo biloba and its constituents. While biflavonoid is a subclass of the flavonoid family in Ginkgo biloba with a plenty of pharmacological properties, the potential tox...
Pyridocarbazole alkaloids from Ochrosia borbonica: lipid-lowering agents inhibit the cell proliferation and adipogenesis of 3T3-L1 adipocyte via intercalating into supercoiled DNA [0.03%]
来自Ochrosia borbonica的吡啶咔唑生物碱：通过嵌入超螺旋DNA降低血脂活性成分可抑制3T3-L1脂肪细胞增殖和促脂生成作用
Yao-Hao Xu,Wei Li,Yong Rao et al.
Yao-Hao Xu et al.
Bioassay-guided fractionation of an ethanolic extract of Ochrosia borbonica led to the isolation of two known pyridocarbazole alkaloids, ellipticine (1) and 9-methoxyellipticine (2), and six known monoterpenoid indole alkaloids (3-8). Lipid...
Exploration of the mechanisms of Ge Gen Decoction against influenza A virus infection [0.03%]
探究桂枝汤对抗流感病毒感染的机制研究
Zi-Kai Geng,Ya-Qun Li,Qing-Hua Cui et al.
Zi-Kai Geng et al.
Ge Gen Decoction (GGD), a Traditional Chinese Medicine prescription, is mainly used to treat infectious respiratory diseases and can relieve the symptoms of influenza A virus (IAV) infection. However, the underlying mechanism of GGD against...
Bupleurum polysaccharides ameliorated renal injury in diabetic mice associated with suppression of HMGB1-TLR4 signaling [0.03%]
防风草多糖通过抑制HMGB1-TLR4信号减轻糖尿病小鼠肾损伤
Zhen-Zhen Liu,Hong-Bo Weng,Li-Jie Zhang et al.
Zhen-Zhen Liu et al.
Bupleurum polysaccharides (BPs) is isolated from Bupleurum smithii var. parvifolium, a key traditional Chinese medicine. The study was to investigate the effects of BPs on diabetic kidney injury. After two intraperitoneal injections of stre...
Determination of five neurotransmitters in the rat brain for the study of the hypnotic effects of Ziziphi Spinosae Semen aqueous extract on insomnia rat model by UPLC-MS/MS [0.03%]
乌梅水提物诱导大鼠睡眠机制研究--脑内五种神经递质的UPLC-MS/MS分析方法建立及应用
Yan Yan,Qiang Li,Hui-Zhi DU et al.
Yan Yan et al.
Ziziphi Spinosae Semen (ZSS) has been used for treatment of insomnia in China for centuries. To reveal the influence of insomnia on the levels of the neurotransmitters including serotonin (5-HT), glutamic acid (Glu), γ-aminobutyric acid (G...