Diphenylemestrins A-E: diketopiperazine-diphenyl ether hybrids from Aspergillus nidulans [0.03%]
来自Aspergillus nidulans的Diphenylemestrin A-E：二酮哌嗪-茋醚杂化物
Aimin Fu,Qin Li,Yang Xiao et al.
Aimin Fu et al.
A chemical investigation of secondary metabolites (SMs) from Aspergillus nidulans resulted in the identification of five novel dioxopiperazine (DKP)-diphenyl ether hybrids, designated as diphenylemestrins A-E (1-5). These compounds 1-5 repr...
Deciphering the therapeutic potential and mechanisms of Artemisia argyit essential oil on flagellum-mediated Salmonella infections [0.03%]
Linlin Ding,Lei Xu,Na Hu et al.
Linlin Ding et al.
Salmonellosis represents a global epidemic, and the emergence of extensively drug-resistant (XDR) Salmonella and its sustained transmission worldwide constitutes a significant public health concern. Flagellum-mediated motility serves as a c...
Harmonizing tradition and technology: Liposomal nanocarriers unlocking the power of natural herbs in Traditional Chinese Medicine [0.03%]
传统与科技的融合：中药天然产物liposome载体制备及纳米药剂学研究
Ibrahim Shaw,Aaron Albert Aryee,Yimer Seid Ali et al.
Ibrahim Shaw et al.
Natural herbs demonstrate significant therapeutic potential in managing chronic and complex diseases; however, their clinical application faces limitations due to low bioavailability, instability, toxicity, and herb-drug interactions. Furth...
Emerging evidence of inter-organ interaction on drug transporters under liver injury [0.03%]
肝损伤下药物转运体发生器官间相互作用的证据
Ling Jiang,Ying Deng,Ruijing Mu et al.
Ling Jiang et al.
Dysfunction of drug transporters significantly affects therapeutic outcomes and drug efficacy in patients with liver injury. Clinical and experimental evidence demonstrates that liver injury involves complex inter-organ interactions among t...
The potential therapeutic role of ginsenosides on fibrosis-associated diseases: a review on molecular mechanisms and call for further research [0.03%]
人参皂苷在与纤维化相关疾病中的潜在治疗作用：分子机制及进一步研究的综述
Mengguang Wei,Yue Zhang,Xiaomeng Sun et al.
Mengguang Wei et al.
Fibrosis is characterized as an aberrant reparative process involving the direct replacement of damaged or deceased cells with connective tissue, leading to progressive architectural remodeling across various tissues and organs. This condit...
Intervention of natural products targeting novel mechanisms after myocardial infarction [0.03%]
作用于心梗后新型靶点的天然药物干预研究
Guangjie Tai,Renhua Liu,Tian Lin et al.
Guangjie Tai et al.
Myocardial infarction is a cardiovascular disease (CVD) with high morbidity and mortality, which can trigger a cascade of cardiac pathophysiological changes, including fibrosis, inflammation, ischemia-reperfusion injury (IRI), and ventricul...
Shiya Wang,Mingyi Cao,Yifei Chen et al.
Shiya Wang et al.
Radiopharmaceuticals operate by combining radionuclides with carriers. The radiation energy emitted by radionuclides is utilized to selectively irradiate diseased tissues while minimizing damage to healthy tissues. In comparison to external...
A CYP80B enzyme from Stephania tetrandra enables the 3'-hydroxylation of N-methylcoclaurine and coclaurine in the biosynthesis of benzylisoquinoline alkaloids [0.03%]
防己四氢藤钩素生物碱中的CYP80B酶能催化N-甲基可卡因和可卡因的3'-羟化反应以合成苯异喹啉类生物碱
Yaoting Li,Yuhan Feng,Wan Guo et al.
Yaoting Li et al.
Benzylisoquinoline alkaloids (BIAs) are a structurally diverse group of plant metabolites renowned for their pharmacological properties. However, sustainable sources for these compounds remain limited. Consequently, researchers are focusing...
Evaluation of pharmacokinetics and metabolism of three marine-derived piericidins for guiding drug lead selection [0.03%]
评估三种海洋生物活性物质皮ericidins的药代动力学和代谢作用以指导先导药物的选择
Weimin Liang,Jindi Lu,Ping Yu et al.
Weimin Liang et al.
This study investigates the pharmacokinetics and metabolic characteristics of three marine-derived piericidins as potential drug leads for kidney disease: piericidin A (PA) and its two glycosides (GPAs), glucopiericidin A (GPA) and 13-hydro...
Comprehensive analysis of the antibacterial activity of 5,8-dihydroxy-1,4-naphthoquinone derivatives against methicillin-resistant Staphylococcus aureus [0.03%]
5,8-二羟基-1,4-萘醌衍生物抗甲氧西林耐药金黄色葡萄球菌活性的全面分析
Qingqing Chen,Yuhang Ding,Zhongyi Li et al.
Qingqing Chen et al.
Given the increasing concern regarding antibacterial resistance, the antimicrobial properties of naphthoquinones have recently attracted significant attention. While 1,4-naphthoquinone and its derivatives have been extensively studied, the ...