Berbamine ameliorates ethanol-induced liver injury by inhibition of hepatic inflammation in mice [0.03%]
贝壳杉胺通过抑制小鼠酒精性肝病中的肝脏炎症来改善酒精引起的肝损伤
Xin-Yu Liu,Guan-Nan Chen,Guo-Ming DU et al.
Xin-Yu Liu et al.
Alcoholic liver disease (ALD) has become one of the leading causes of death in the world. Berbamine (BM), a natural product mainly derived from Berberis vulgaris L, possesses multiple bioactivities as a traditional medicine. However, the pr...
MUC1 promotes glycolysis through inhibiting BRCA1 expression in pancreatic cancer [0.03%]
MUC1通过抑制BRCA1表达促进胰腺癌的糖酵解
Xiao Fu,Neng Tang,Wei-Qi Xie et al.
Xiao Fu et al.
Enhanced glucose metabolism is one of the hallmarks of pancreatic cancer. MUC1, a transmembrane protein, is a global regulator of glucose metabolism and essential for progression of pancreatic cancer. To clarify the role of MUC1 in glucose ...
Selenium-enriched Bifidobacterium longum protected alcohol and high fat diet induced hepatic injury in mice [0.03%]
富硒长双歧杆菌通过减轻酒精和高脂饮食诱导的小鼠肝脏损伤保护肝功能研究
Hong-Wei Yi,Xiao-Xiao Zhu,Xiao-Li Huang et al.
Hong-Wei Yi et al.
The objective of this study was to verify the protective effect of Bifidobacterium longum (BL) and the synergistical effect of Selenium and BL on alcohol plus high fat diet (HFD) induced hepatic injury in mice. We also want to explore the m...
Fatty liver diseases, mechanisms, and potential therapeutic plant medicines [0.03%]
脂肪肝的病因、机制与潜在的治疗中草药
Jia-Zhen Zhu,Hong-Wei Yi,Wei Huang et al.
Jia-Zhen Zhu et al.
The liver is an important metabolic organ and controls lipid, glucose and energy metabolism. Dysruption of hepatic lipid metabolism is often associated with fatty liver diseases, including nonalcoholic fatty liver disease (NAFLD), alcoholic...
Profiling the mid-adult cecal microbiota associated with host healthy by using herbal formula Kang ShuaiLao Pian treated mid-adult mice [0.03%]
基于中药康寿劳片的健康干预对中年小鼠盲肠菌群的影响研究
Shu-Qing Gong,Ting-Ting Ye,Mei-Xia Wang et al.
Shu-Qing Gong et al.
With the occurrence of aging process, decreased neuron dopamine, disrupted brown adipose tissue (BAT) remodeling and decreased butyrate level all reflect a weak host healthy in certain degree. Nevertheless, the signs of mid-adult gut microb...
Antitumor activity of nervosine VII, and the crosstalk between apoptosis and autophagy in HCT116 human colorectal cancer cells [0.03%]
神经宁VII抗肿瘤作用及对HCT116人结肠癌细胞凋亡和自噬的调控作用
Shuai Huang,Shuang-Mei Zhao,Lian-Hai Shan et al.
Shuai Huang et al.
Nervosine VII is one of the known saturated pyrrolizidine alkaloids isolated from the plant of Liparis nervosa. This is first study to investigate the antitumor activity of nervosine VII in vitro, and the results indicated that nervosine VI...
Comprehensive analysis of the chemical constituents in sulfur-fumigated Lonicerae Japonicae Flos using UHPLC-LTQ-Orbitrap mass spectrometry [0.03%]
超高压液相色谱-轨道离子阱质量交替聚焦仪分析硫磺熏蒸对金银花化学成分的影响
Zi-Han Liu,Yu-Qi Wang,Xiao-Dan Mei et al.
Zi-Han Liu et al.
Lonicerae Japonicae Flos (LJF), a kind of traditional Chinese medicines (TCMs), has functions of detoxifying and evacuating heat. In the study, a method based on ultra-high performance liquid chromatography coupled with linear ion trap-Orbi...
Liver metabonomics study on the protective effect of glycyrrhetinic acid against realgar-induced liver injury [0.03%]
甘草酸保护雄黄致小鼠肝损伤的肝脏代谢组学研究
Tao-Guang Huo,Ying Fang,Ying-Hua Zhang et al.
Tao-Guang Huo et al.
Glycyrrhetinic acid (GA) is the bioactive ingredient in Glycyrrhizae Radix et Rhizoma. Our previous study has reported that GA has protective effect on realgar-induced hepatotoxicity. However, the details of the hepatoprotective mechanisms ...
Quantitative proteomics analysis of Fructus Psoraleae-induced hepatotoxicity in rats [0.03%]
补骨脂致小鼠肝损伤的定量蛋白质组学分析
Zhi-Jian Li,Abulizi Abudumijiti,Deng-Qiu Xu et al.
Zhi-Jian Li et al.
Fructus Psoraleae, which is commonly consumed for the treatment of osteoporosis, bone fracture, and leucoderma, induces liver injury. This study investigated the pathogenesis of the ethanol extract of Fructus Psoraleae (EEFP)-induced liver ...
Curcumin-induced cell death depends on the level of autophagic flux in A172 and U87MG human glioblastoma cells [0.03%]
姜黄素诱导的细胞死亡依赖于A172和U87MG人胶质母细胞瘤细胞中的自噬通量水平
Jong-Eun Lee,Sung Sik Yoon,Jae-Wook Lee et al.
Jong-Eun Lee et al.
Glioblastoma is the deadliest neoplasm with the worst 5-year survival rate among all human cancers. Autophagy promotes autophagic cell death or blocks the induction of apoptosis in eukaryotic cells. Here, we investigated whether varying lev...