Xin Zhang,Yang Sun,Ying Cheng et al.
Xin Zhang et al.
To study the biopharmaceutics characteristics of paris saponin VII (PSVII). The solubility of PSVII was evaluated by measurement of the equilibrium solubility in different solvents and media. The permeability of PSVII was evaluated by measu...
Nao-Fu-Cong ameliorates diabetic cognitive dysfunction by inhibition of JNK/CHOP/Bcl2-mediated apoptosis in vivo and in vitro [0.03%]
Nao-Fu-Cong通过抑制JNK / CHOP / Bcl2介导的凋亡改善糖尿病认知功能障碍体内和体外研究
Guang-Chan Jing,Di Liu,Yu-Qin Liu et al.
Guang-Chan Jing et al.
Chinese herbal compound Nao-Fu-Cong (NFC) has been mainly used to treat cognitive disorders in Traditional Chinese Medicine (TCM). The present study aimed to investigate whether its neuroprotective effects might be related to the inhibition...
Natural products as potent inhibitors of hypoxia-inducible factor-1α in cancer therapy [0.03%]
天然产物作为癌症治疗中有效的低氧诱导因子-1α抑制剂
Jin-Cheng Zhong,Xiao-Bo Li,Wen-Yu Lyu et al.
Jin-Cheng Zhong et al.
Hypoxia is a prominent feature of tumors. Hypoxia-inducible factor-1α (HIF-1α), a major subunit of HIF-1, is overexpressed in hypoxic tumor tissues and activates the transcription of many oncogenes. Accumulating evidence has demonstrated ...
Candidate genes involved in the biosynthesis of lignan in Schisandra chinensis fruit based on transcriptome and metabolomes analysis [0.03%]
基于转录组和代谢物分析研究五味子果实中木质素合成的候选基因
Chun-Yu Chen,Shu-Ying Liu,Yan Yan et al.
Chun-Yu Chen et al.
Schisandra chinensis Turcz. (Baill.) is a plant species with fruits that have been well known in Far Eastern medicine for a long time. It has traditionally been used as a stimulating and fortifying agent in cases of physical exhaustion and ...
Characterization of inthomycin biosynthetic gene cluster revealing new insights into carboxamide formation [0.03%]
inthomycin生物合成基因簇的特征揭示了羧酰胺形成的新见解
Yong-Jiang Wang,Li Wang,Xin He et al.
Yong-Jiang Wang et al.
Inthomycins are polyketide antibiotics which contain a terminal carboxamide group and a triene chain. Inthomycin B (1) and its two new analogues 2 and 3 were isolated from the crude extract of Streptomyces pactum L8. Identification of the g...
Engineering CrtW and CrtZ for improving biosynthesis of astaxanthin in Escherichia coli [0.03%]
通过工程改造CrtW和CrtZ来提高大肠杆菌中虾青素的生物合成路径
Di Li,Yang Li,Jiao-Yang Xu et al.
Di Li et al.
This study engineered β-carotene ketolase CrtW and β-carotene hydroxylase CrtZ to improve biosynthesis of astaxanthin in Escherichia coli. Firstly, crtW was randomly mutated to increase CrtW activities on conversion from β-carotene to as...
Molecular cloning and functional characterization of multiple ApOSCs from Andrographis paniculata [0.03%]
多种穿心莲ApOSC的分子克隆与功能鉴定
Jian Wang,Hui-Xin Lin,Huan Zhao et al.
Jian Wang et al.
Triterpenoids have been described in Andrographis paniculata. Oleanolic acid exhibits high biological activity and is widely used in the clinic, and β-sitosterol not only has good biological activity but also plays an important physiologic...
Advance in glycosyltransferases, the important bioparts for production of diversified ginsenosides [0.03%]
糖基转移酶的研究进展：用于生产多样化人参皂苷的重要生物元件部分
Jia-Ning Zhao,Ru-Feng Wang,Shu-Juan Zhao et al.
Jia-Ning Zhao et al.
Ginsenosides are a series of glycosylated triterpenoids predominantly originated from Panax species with multiple pharmacological activities such as anti-aging, mediatory effect on the immune system and the nervous system. During the biosyn...
Wei Gao,Lu-Qi Huang
Wei Gao