TCM network pharmacology: A new trend towards combining computational, experimental and clinical approaches [0.03%]
计算、实验与临床相合的网络药理学新趋势：中药作用复杂性的破解之道
Xin Wang,Zi-Yi Wang,Jia-Hui Zheng et al.
Xin Wang et al.
Traditional Chinese medicine (TCM) is a precious treasure of the Chinese nation and has unique advantages in the prevention and treatment of diseases. The holistic view of TCM coincides with the new generation of medical research paradigm c...
Study on the secondary metabolites of grasshopper-derived fungi Arthrinium sp. NF2410 [0.03%]
草地杂食真菌Arthrinium sp. NF2410次级代谢产物研究
Wei Li,Jing Wei,Dao-Ying Chen et al.
Wei Li et al.
Two new 2-carboxymethyl-3-hexyl-maleic anhydride derivatives, arthrianhydride A (1) and B (2), along with three known compounds 3-5, were isolated from the fermentation broth of a grasshopper-associated fungus Arthrinium sp. NF2410. The str...
Shunt products of aminoansamycins from aas1 overexpressed mutant strain of Streptomyces sp. S35 [0.03%]
从过表达工程菌株S35中分流氨基糖肽类抗生素AAS1的类似物及其新衍生物
Li-Ping Dai,Zi-Shen Wang,Hao-Xin Wang et al.
Li-Ping Dai et al.
Constitutively expression of the pathway-specific activators is an effective method to activate silent gene clusters and improve natural product production. In this study, nine shunt products of aminoansamycins (1-9) were identified from a ...
Traditional Chinese medicine network pharmacology study on exploring the mechanism of Xuebijing Injection in the treatment of coronavirus disease 2019 [0.03%]
基于网络药理学的血必净治疗新冠肺炎作用机制研究
Yan Xing,Ying-Rong Hua,Jing Shang et al.
Yan Xing et al.
As a representative drug for the treatment of severe community-acquired pneumonia and sepsis, Xuebijing (XBJ) injection is also one of the recommended drugs for the prevention and treatment of coronavirus disease 2019 (COVID-19), but its tr...
Ganoderic acid A protects lens epithelial cells from UVB irradiation and delays lens opacity [0.03%]
灵芝酸A保护晶状体上皮细胞免受UVB辐射并延缓白内障发生
Li-Hua Kang,Guo-Wei Zhang,Jun-Fang Zhang et al.
Li-Hua Kang et al.
A contributory role of oxidative stress and protection by antioxidant nutrients have been suspected in cataract formation. Ganoderic acid A (GAA), an effective lanostane triterpene, is widely reported as an antioxidant. The aim of this stud...
Effect of quercetin on chondrocyte phenotype and extracellular matrix expression [0.03%]
槲皮素对软骨细胞表型和细胞外基质表达的影响
Zhi-Peng Gui,Yue Hu,Yu-Ning Zhou et al.
Zhi-Peng Gui et al.
Due to the poor repair ability of cartilage tissue, regenerative medicine still faces great challenges in the repair of large articular cartilage defects. Quercetin is widely applied as a traditional Chinese medicine in tissue regeneration ...
Development of liquiritigenin-phospholipid complex with the enhanced oral bioavailability [0.03%]
一种具有增强口服生物利用度的甘草素-磷脂复合物的开发研究
Chang-Can Shi,Kun-Ming Qin,Ke Xu et al.
Chang-Can Shi et al.
In the present study, liquiritigenin-phospholipid complex (LPC) was developed and evaluated to increase the oral bioavailability of liquiritigenin. A single-factor test methodology was applied to optimize the formulation and process for pre...
The cardiovascular protective effect and mechanism of calycosin and its derivatives [0.03%]
苦参碱及其衍生物的血管保护作用及机制研究
Li Pan,Xuan-Fen Zhang,Wan-Sheng Wei et al.
Li Pan et al.
Cardiovascular disease is the main cause of mortality and morbidity in the world, especially in developing countries. Drug therapy is one of the main ways to treat cardiovascular diseases. Among them, great progress has been made in the tre...
Taurochenodeoxycholic acid mediates cAMP-PKA-CREB signaling pathway [0.03%]
taurolithocholic酸介导cAMP-PKA-CREB信号通路
You-Chao Qi,Guo-Zhen Duan,Wei Mao et al.
You-Chao Qi et al.
Taurochenodeoxycholic acid (TCDCA) is one of the main effective components of bile acid, playing critical roles in apoptosis and immune responses through the TGR5 receptor. In this study, we reveal the interaction between TCDCA and TGR5 rec...
Research progress on the source, production, and anti-cancer mechanisms of paclitaxel [0.03%]
紫杉醇的来源、制备及抗肿瘤机制研究进展
Yan-Hua Yang,Jia-Wang Mao,Xiao-Li Tan
Yan-Hua Yang
Paclitaxel, a tetracyclic diterpenoid compounds, was firstly isolated from the bark of the Pacific yew trees. Currently, as a low toxicity, high efficiency, and broad-spectrum natural anti-cancer drug, paclitaxel has been widely used agains...