Wenxia Changfu Formula inhibits NSCLC metastasis by halting TAMs-induced epithelial-mesenchymal transition via antagonisticallymodulating CCL18 [0.03%]
温下昌符方通过拮抗调控CCL18抑制巨噬细胞诱导的上皮间质转化从而抑制非小细胞肺癌转移的作用研究
Qianyu Bi,Mengran Wang,Li Luo et al.
Qianyu Bi et al.
Our previous research demonstrated that the Wenxia Changfu Formula (WCF), as a neoadjuvant therapy, inhibits M2 macrophage infiltration in the tumor microenvironment and prevents lung cancer metastasis. Given tumor-associated macrophages (T...
Naturally occurring seco- and nor-polycyclic polyprenylated acylphloroglucinols: distribution, structural diversity, andbiological activity [0.03%]
天然倍半蒈烯基acylphloroglucinol及其衍生的seco-和nor-多环型衍生物：分布、结构多样性和生物学活性
Yulin Duan,Ying Tang,Changxing Qi et al.
Yulin Duan et al.
Polycyclic polyprenylated acylphloroglucinols (PPAPs) represent a distinct subclass of specialized metabolites predominantly found in the plant kingdom, particularly within the Guttiferae (Clusiaceae) family. These compounds exhibit remarka...
The role of 8-OxoG and its repair systems in liver diseases progression: responsible mechanisms and promising natural products [0.03%]
8-氧代鸟嘌呤及其修复系统在肝病进展中的作用：责任机制及前景天然产物
Ying Zheng,Junxin Chen,Ze Liu et al.
Ying Zheng et al.
The accumulation of deoxyribonucleic acid (DNA) oxidative damage mediated by reactive oxygen species (ROS) is closely associated with liver diseases. 8-Oxoguanine (8-OxoG), a prevalent DNA oxidation product, plays a significant role in live...
First-in-class drug oroxylin A tablets for treating hepatic and gastrointestinal disorders: from preclinical development to clinical research [0.03%]
一类新药黄芩素治疗肝胃疾病的从药效学研究到临床试验阶段的研究
Chengju Luo,Xuhong Li,Yuan Gao et al.
Chengju Luo et al.
Oroxylin A (OA) is a natural flavonoid primarily derived from the plants Oroxylum indicum and Scutellaria baicalensis. Currently, OA is obtainable through chemical synthesis and exhibits polypharmacological properties, including anti-cancer...
Host-microbe co-metabolism system as potential targets: the promising way for natural medicine to treat atherosclerosis [0.03%]
宿主微生物共代谢系统作为潜在靶点：天然药物治疗动脉粥样硬化的新方向
Yun Wang,Ziwei Zhou,Haiping Hao et al.
Yun Wang et al.
The host-microbe co-metabolism system, generating diverse exogenous and endogenous bioactive molecules that influence the host's immune and metabolic functions, plays a crucial role in the pathogenesis of atherosclerosis. Recent studies hav...
Haizheng Yu,Fen Lan,Yuan Zhuang et al.
Haizheng Yu et al.
Paclitaxel (PTX), a valuable natural product derived from Taxus species, exhibits remarkable anti-cancer properties. It penetrates nanopores in microtubule walls, interacting with tubulin on the lumen surface and disrupting microtubule dyna...
Withanolide derivatives from Physalis angulata var. villosa and their cytotoxic activities [0.03%]
粗糙枸杞中的_withanolide_衍生物及其细胞毒活性
Peng Wang,Jue Yang,Yu Zhang et al.
Peng Wang et al.
A comprehensive phytochemical investigation of the leaves and twigs of Physalis angulata. var. villosa resulted in the isolation of 23 withanolide derivatives, including one novel 13,20-γ-lactone withanolide derivative (1) and three new wi...
Bioactivity-guided discovery of antiviral templichalasins A‒C from the endophytic fungus Aspergillus templicola [0.03%]
基于生物活性的抗病毒化合物templichalasins A-C的发现及活性研究
Teng Cai,Jingzu Sun,Wenxuan Chen et al.
Teng Cai et al.
The bioactivity-guided isolation of potentially active natural products has been widely utilized in pharmaceutical discovery. In this study, by screening fungal extracts against coxsackievirus B3 (CVB3), three new aspochalasins, templichala...
Oroxylin A inhibits UVB-induced non-melanoma skin cancer by regulating XPA degradation [0.03%]
黄芩素A通过调节XPA降解抑制非黑色素瘤皮肤癌产生
Renjie Dou,Jiarui Sun,Hang Yang et al.
Renjie Dou et al.
Oroxylin A (OA), a natural compound extracted from Scutellaria baicalensis, demonstrates preventive potential against ultraviolet B (UVB)-induced non-melanoma skin cancer (NMSC), the most prevalent cancer worldwide with increasing incidence...
Combination of Astragalus-Salvia and Ophiopogon-Dendrobium herb pairs alleviates Sjögren's Syndrome via inhibiting the JAK1/STAT3 and PI3K/AKT pathways in NOD/Ltj mice [0.03%]
当归党参麦冬石斛药对通过抑制NOD小鼠JAK1/STAT3和PI3K/AKT信号通路治疗舍格伦综合征
Peng Sun,Lili Zhu,Yang Yu et al.
Peng Sun et al.
Sjögren's syndrome (SS) is an autoimmune disease characterized primarily by oral and periocular dryness. Astragalus-Salvia (AS) and Ophiopogon-Dendrobium (OD) represent two frequently utilized herb pairs in SS treatment. While the combinat...