Paris saponin VII, a direct activator of AMPK, induces autophagy and exhibits therapeutic potential in non-small-cell lung cancer [0.03%]
巴黎莫素VII通过直接激活AMPK诱导自噬并展现出对非小细胞肺癌的治疗潜力
Yu-Chen Xiang,Jie Shen,Yuan Si et al.
Yu-Chen Xiang et al.
Paris saponin VII (PSVII), a bioactive constituent extracted from Trillium tschonoskii Maxim., is cytotoxic to several cancer types. This study was designed to explore whether PSVII prevents non-small-cell lung cancer (NSCLC) proliferation ...
Altered integrity of hepatocyte tight junctions in rats with triptolide-induced cholestasis [0.03%]
三氧茋所致肝胆汁淤积大鼠肝细胞紧密连接结构及通透性的改变
Shan Huang,Li Liu,Hui-Fang Mei et al.
Shan Huang et al.
Triptolide (TP), an active component of Tripterygium wilfordiiHook. f. (TWHF), has been widely used for centuries as a traditional Chinese medicine. However, the clinical application of TP has been restricted due to multitarget toxicity, su...
Anti-rheumatoid arthritis potential of diterpenoid fraction derived from Rhododendron molle fruits [0.03%]
滇白珠果实二萜组分抗类风湿关节炎活性研究
Yan-Chen He,Yu-Min Yao,Qiu-Wen Xue et al.
Yan-Chen He et al.
Rhododendron molle G. Don is first recorded in Shengnong's Herbal Classic, and its fruits, which are termed as Liuzhouzi, are often used to treat rheumatoid arthritis in Chinese folk. During our ongoing investigation to develop a safer and ...
Ligustroflavone ameliorates CCl4-induced liver fibrosis through down-regulating the TGF-β/Smad signaling pathway [0.03%]
Ligustroflavone通过下调TGF-β / Smad信号通路缓解CCl4诱导的肝纤维化
Rong Kang,Wen Tian,Wei Cao et al.
Rong Kang et al.
Liver fibrosis is a pathological process characterized by excess deposition of extracellular matrix (ECM) that are mainly derived from activated hepatic stellate cells. Previous studies suggested that ligustroflavone (LF) was an ingredient ...
Gualou-Xiebai-Banxia decoction protects against type II diabetes with acute myocardial ischemia by attenuating oxidative stress and apoptosis via PI3K/Akt/eNOS signaling [0.03%]
瓜蒌薤白半夏汤通过PI3K/Akt/eNOS信号通路抗氧化和减少凋亡对2型糖尿病急性心肌缺血的保护作用
Yao Fu,Ji-Dong Zhou,Xiao-Yu Sang et al.
Yao Fu et al.
Gualou-Xiebai-Banxia decoction has a long history of medical use for treating cardiovascular diseases in China. In this study, we investigated the protective effect and underlying mechanisms GXB in type II diabetes with acute myocardial isc...
Protective effect of paeoniflorin on H2O2 induced Schwann cells injury based on network pharmacology and experimental validation [0.03%]
基于网络药理学和实验验证的芍药苷保护H₂O₂诱导施万细胞损伤的作用研究
Di Zhang,Bing Yang,Shi-Quan Chang et al.
Di Zhang et al.
This study was to investigate the protective effect of paeoniflorin (PF) on hydrogen peroxide-induced injury. Firstly, "SMILES" of PF was searched in Pubchem and further was used for reverse molecular docking in Swiss Target Prediction data...
cDNA cloning of a novel lectin that induce cell apoptosis from Artocarpus hypargyreus [0.03%]
取自动物蛋白苦瓜树Agglutinin-A基因的克隆及序列分析
Yu Luo,Lin-Jie Zeng,Xiao-Qin Liu et al.
Yu Luo et al.
We isolated a novel lectin (AHL) from Artocarpus hypargyreusHance and showed its immunomodulatory activities. In this study, the amino acid sequence of AHL was determined by cDNA sequencing. AHL cDNA (875bp) contains a 456-bp open reading f...
The effects of borneol on the pharmacokinetics and brain distribution of tanshinone IIA, salvianolic acid B and ginsenoside Rg1 in Fufang Danshen preparation in rats [0.03%]
冰片对复方丹参制剂中丹参素、丹参酮ⅡA和人参皂苷Rg1药代动力学及脑内分布影响研究
Jie Zhang,Sheng-Lan Liu,Hui Wang et al.
Jie Zhang et al.
Fufang Danshen preparation (FDP) is consisted of Salviae Miltiorrhizar Radix et Rhizoma (Danshen), Notoginseng Radix et Rhizoma (Sanqi) and Borneolum Syntheticum (borneol). FDP is usually used to treat myocardial ischemia hypoxia, cerebral ...
Jiedu Sangen decoction inhibits chemoresistance to 5-fluorouracil of colorectal cancer cells by suppressing glycolysis via PI3K/AKT/HIF-1α signaling pathway [0.03%]
基于PI3K/AKT/HIF-1α信号通路抑制糖酵解的泻겐삼환煎通过抑制糖酵解诱导5-氟尿嘧啶耐药性 colorectal cancer cells
Lei-Tao Sun,Le-Yin Zhang,Fei-Yu Shan et al.
Lei-Tao Sun et al.
Drug resistance is a major obstacle in the development of effective colorectal cancer (CRC) therapy. Our study aimed to explore the reversal abilities of Jiedu Sangen decoction (JSD) on the 5-fluorouracil (5-FU) resistance and its underlyin...
Artemisia kruhsiana leaf extract induces autophagic cell death in human prostate cancer cells [0.03%]
芸蓬叶提取物通过自噬诱导人前列腺癌细胞死亡
Se-Eun Lee,Sardana Sivtseva,Chiyeon Lim et al.
Se-Eun Lee et al.
Some species of Artemisia have been reported to induce apoptosis and autophagy, but little is known of the apoptotic and autophagic effects of the stems and leaves of Artemisia kruhsiana Bess. (AkB). This study was conducted to investigate ...