Comprehensive profiling and characterization of the absorbed components and metabolites in mice serum and tissues following oral administration of Qing-Fei-Pai-Du decoction by UHPLC-Q-Exactive-Orbitrap HRMS [0.03%]
基于UHPLC-Q-Exactive-Orbitrap高分辨质谱的清肺排毒汤口服给药后小鼠血浆及组织中吸收入血成分和代谢产物的综合剖析与特征研究
Wei Liu,Jian Huang,Feng Zhang et al.
Wei Liu et al.
Qing-Fei-Pai-Du decoction (QFPDD) is a Chinese medicine compound formula recommended for combating corona virus disease 2019 (COVID-19) by National Health Commission of the People's Republic of China. The latest clinical study showed that e...
Simple and robust differentiation of Ganoderma species by high performance thin-layer chromatography coupled with single quadrupole mass spectrometry QDa [0.03%]
一种简单可靠的灵芝属真菌鉴别方法：高效薄层色谱-单四极杆质谱QDa联用技术
Shuai Yao,Jian-Qing Zhang,Jin-Jun Hou et al.
Shuai Yao et al.
In this study, a high performance thin-layer chromatography/single quadrupole mass spectrometry QDa (HPTLC-QDa) method for robust authentication of Ganoderma lucidum, a popular and valuable herbal medicine, has been developed. This method i...
Characterization of the chemical constituents of Jie-Geng-Tang and the metabolites in the serums and lungs of mice after oral administration by LC-Q-TOF-MS [0.03%]
液质联用法研究桔梗汤化学成分及其经口给药后在小鼠血浆和肺部代谢物的变化
Yin-Ning Liu,Meng-Ting Hu,Jing Qian et al.
Yin-Ning Liu et al.
Jie-Geng-Tang (JGT), a traditional formula, is employed in the treatment of sore throat and cough and comprises Platycodonis Radix and Glycyrrhizae Radix et Rhizoma in the ratio 1 : 2. Our previous study demonstrated that JGT protected mice...
Compound Sophorae Decoction: treating ulcerative colitis by affecting multiple metabolic pathways [0.03%]
槐角丸通过多条代谢通路治疗溃疡性结肠炎
Zong-Chao Hong,Quan Cai,He-Zhen Wu et al.
Zong-Chao Hong et al.
Ulcerative colitis (UC) is a chronic refractory non-specific intestinal inflammatory disease that is difficult to be cured. The discovery of new ulcerative colitis-related metabolite biomarkers may help further understand UC and facilitate ...
Polyphyllin I promotes cell death via suppressing UPR-mediated CHOP ubiquitination and degradation in non-small cell lung cancer [0.03%]
姜黄素衍生物桃叶珊瑚苷I通过抑制UPR介导的C/EBP同源蛋白泛素化和降解促进非小细胞肺癌细胞死亡
Ming-Ming Liu,Miao-Lin Zhu,Rui-Fang Dong et al.
Ming-Ming Liu et al.
Polyphyllin I (PPI) purified from Polyphyllarhizomes displays puissant cytotoxicity in many kinds of cancers. Several researches investigated its anti-cancer activity. But novel mechanisms are still worth investigation. This study aimed to ...
Mechanisms exploration of Angelicae Sinensis Radix and Ligusticum Chuanxiong Rhizoma herb-pair for liver fibrosis prevention based on network pharmacology and experimental pharmacologylogy [0.03%]
基于网络药理学和实验药理学的当归-川芎对肝纤维化防治机制探讨研究
Jian-Zhi Wu,Ya-Jing Li,Guang-Rui Huang et al.
Jian-Zhi Wu et al.
Angelicae Sinensis Radix (Danggui) and Ligusticum Chuanxiong Rhizoma (Chuan Xiong) herb-pair (DC) have been frequently used in Traditional Chinese medicine (TCM) prescriptions for hundreds of years to prevent vascular diseases and alleviate...
Preparation and evaluation of a water-in-oil nanoemulsion drug delivery system loaded with salidroside [0.03%]
载有山柳苷素的油包水纳米乳药物传递系统的制备及评价研究
Chun-Xia Liang,Dong-Li Qi,Li-Na Zhang et al.
Chun-Xia Liang et al.
Salidroside (SAL) is a phenolic substance with high solubility and low permeability, which make it easy to cause the efflux effect of P-glycoprotein and degradation of intestinal flora, resulting in lower bioavailability. The aim of this st...
Shou-Yuan Wu,Meng Bai,Qi Zhou et al.
Shou-Yuan Wu et al.
The phytochemical investigation of the stems of Homalium stenophyllum afforded seven new phenolic glycosides (1-5 and 8-9) and two known compounds (6 and 7). Their structures were elucidated by comprehensive analyses of NMR spectroscopic, m...
Comparative metabolism study on chlorogenic acid, cryptochlorogenic acid and neochlorogenic acid using UHPLC-Q-TOF MS coupled with network pharmacology [0.03%]
超高效液相色谱-高分辨质谱联用及网络药理学结合的绿原酸、异绿原酸和新绿原酸代谢组学研究
Jie Li,Shao-Ping Wang,Yu-Qi Wang et al.
Jie Li et al.
Chlorogenic acid (5-CQA), neochlorogenic acid (3-CQA), and cryptochlorogenic acid (4-CQA), usually simultaneously exist in many traditional Chinese medicines (TCMs). However, insufficient attentions have been paid to the comparative metabol...
Regulation of RDN on Th1/ILC1 cell imbalance in HFMD patients caused by EV71 infection [0.03%]
RDN调控肠道病毒感染的手足口病患者Th1/ILC1细胞失衡作用机制研究
Yi-Meng Wang,Ye Tian,Qian-Wen Li et al.
Yi-Meng Wang et al.
Enterovirus 71 (EV71) infection is more likely to cause hand, foot and mouth disease (HFMD) in children, which can lead to neurogenic complications and higher mortality. As a commonly used clinical medicine, Reduning injection (RDN) helps t...