Transcriptomic profile of human erythroleukemia cells in response to Sargassum fusiforme polysaccharide and its structure analysis [0.03%]
长柄海带多糖对人红白血病细胞转录组的影响及其结构分析
Hao-Miao Ding,Rui-Jie Fu,Ce Xie et al.
Hao-Miao Ding et al.
Sargassum fusiforme (S. fusiforme) has been used as an ingredient in Chinese herbal medicine for thousands of years. However, there are a limited number of studies concerning its therapeutic mechanism. High performance gel permeation chroma...
Danshen-Chuanxiongqin Injection attenuates cerebral ischemic stroke by inhibiting neuroinflammation via the TLR2/ TLR4-MyD88-NF-κB Pathway in tMCAO mice [0.03%]
丹参清注射液通过抑制TLR2/TLR4-MyD88-NF-κB通路的神经炎症来减轻小鼠局灶性脑缺血再灌注损伤后的脑卒中
Xiao-Jing Xu,Jin-Bo Long,Kai-Yu Jin et al.
Xiao-Jing Xu et al.
Danshen-Chuanxiongqin Injection (DCI) is a commonly used traditional Chinese medicine for the treatment of cerebral ischemic stroke in China. However, its underlying mechanisms remain completely understood. The current study was designed to...
Investigation of the metabolites of five major constituents from Berberis amurensis in normal and pseudo germ-free rats [0.03%]
五味子正伯伯根草中五大主要成分的代谢物在正常的大鼠和假无菌大鼠中的研究
Cui-Ping Liao,Xing-Chao Liu,Shi-Qi Dong et al.
Cui-Ping Liao et al.
Berberis amurensis (Berberidaceae) is a traditional Chinese medicine, which is often used to treat hypertension, inflammation, dysentery and enteritis. It contains alkaloids, mainly including berberine, berbamine, magnoflorine, jatrorrhizin...
Tripterygium wilfordii multiglycoside-induced hepatotoxicity via inflammation and apoptosis in zebrafish [0.03%]
雷公藤多苷通过炎症和凋亡引起斑马鱼肝毒性的研究
Xiu-Ying Duan,Rui-Jiao Ma,Chung-Der Hsiao et al.
Xiu-Ying Duan et al.
Tripterygium wilfordii multiglycoside (GTW) is a commonly used compound for the treatment of rheumatoid arthritis (RA) and immune diseases in clinical practice. However, it can induce liver injury and the mechanism of hepatotoxicity is stil...
Therapeutic effect of neohesperidin on TNF-α-stimulated human rheumatoid arthritis fibroblast-like synoviocytes [0.03%]
新黄酮对TNF-α刺激的人类类风湿性关节炎成纤维细胞样滑膜细胞的治疗作用
Xiao-He Wang,Ce Dai,Jun Wang et al.
Xiao-He Wang et al.
During the pathogensis of rheumatoid arthritis (RA), activated RA fibroblast-like synoviocytes (RA-FLSs) combines similar proliferative features as tumor and inflammatory features as osteoarthritis, which eventually leads to joint erosion. ...
Physalin B reduces Aβ secretion through down-regulation of BACE1 expression by activating FoxO1 and inhibiting STAT3 phosphorylation [0.03%]
physalin B通过激活FoxO1和抑制STAT3磷酸化下调BACE1表达从而降低Aβ分泌
Wei Zhang,Shan-Shan Bai,Qi Zhang et al.
Wei Zhang et al.
Physalin B (PB), one of the major active steroidal constituents of Solanaceae Physalis plants, has a wide variety of biological activities. We found that PB significantly down-regulated β-amyloid (Aβ) secretion in N2a/APPsw cells. However...
Effects of chitooligosaccharide-zinc on the ovarian function of mice with premature ovarian failure via the SESN2/NRF2 signaling pathway [0.03%]
壳寡糖锌通过SESN2/NRF2信号通路对早发性卵巢功能不全小鼠卵巢功能的影响效应研究
Jia Li,Yu-Hang Chen,Jia-Yu Xu et al.
Jia Li et al.
Chitooligosaccharide-zinc (COS·Zn) is a powerful anti-oxidant and anti-aging scavenger, whose anti-oxidative ability immensely exceeds vitamin C. Therefore, this study was aimed to investigate the protective effects of COS·Zn against prem...
Comparison of Murraya exotica and Murraya paniculata by fingerprint analysis coupled with chemometrics and network pharmacology methods [0.03%]
指纹分析结合化学计量学和网络药理学方法比较凤仙花和无刺紫薇的关系
Hai-Zhen Liang,Zhi-Yong DU,Shuo Yuan et al.
Hai-Zhen Liang et al.
There are two source plants for the traditional Chinese medicine Murrayae Folium et Cacumen (MFC) in Chinese Pharmacopoeia, i.e. Murraya exotica L. and M. paniculata (L.) Jack. Herein, a chemical comparison of M. exotica and M. paniculata b...
Sulfite as the substrate of C-sulfonate metabolism of α, β-unsaturated carbonyl containing andrographolide: analysis of sulfite in rats' intestinal tract and the reaction kinetics of andrographolide with sulfite [0.03%]
含α，β不饱和羰基穿心莲内酯C-磺酸代谢的底物亚硫酸盐：大鼠肠道中亚硫酸盐分析及穿心莲内酯与亚硫酸盐反应动力学研究
Zhi-Peng Huo,Xin-Chi Feng,Yu Wang et al.
Zhi-Peng Huo et al.
One-sixth of the currently known natural products contain α, β-unsaturated carbonyl groups. Our previous studies reported a rare C-sulfonate metabolic pathway. Sulfonate groups were linked to the β-carbon of α, β-unsaturated carbonyl-b...
Jian Zou,Shuai Zhang,Huan Zhao et al.
Jian Zou et al.
Biotransformation of α-asarone by Alternaria longipes CGMCC 3.2875 yielded two pairs of new neolignans, (+) (7S, 8S, 7'S, 8'R) iso-magnosalicin (1a)/(-) (7R, 8R, 7'R, 8'S) iso-magnosalicin (1b) and (+) (7R, 8R, 7'S, 8'R) magnosalicin (2a)/...