Xinglou Chengqi Decoction improves neurological function in experimental stroke mice as evidenced by gut microbiota analysis and network pharmacology [0.03%]
基于网络药理学和肠道菌群分析的星蒌承气汤改善卒中模型小鼠神经功能损伤的作用研究
Qiang Gao,Zhen-Yun Han,Dan-Feng Tian et al.
Qiang Gao et al.
The current study was designed to explore the brain protection mechanism of Xinglou Chengqi Decoction (XCD) based on gut microbiota analysis and network pharmacology. A transient middle cerebral artery occlusion (MCAO) model of mice was est...
Cytotoxic diaporindene and tenellone derivatives from the fungus Phomopsis lithocarpus [0.03%]
来自Phomopsis lithocarpus真菌的细胞毒性二孢尔烷和地脚菇素衍生物
Hui-Bo Liu,Zhao-Ming Liu,Yu-Chan Chen et al.
Hui-Bo Liu et al.
Nine new compounds, including five natural rarely-occurring 2, 3-dihydro-1H-indene derivatives named diaporindenes E-I (1-5), and four new benzophenone analogues named tenellones J-M (6-9) were isolated from the deep-sea sediment-derived fu...
Three new carabrane sesquiterpenoid derivatives from the whole plant of Carpesium abrotanoides L [0.03%]
来源于翠菊全草的三个新的车叶草烷型倍半萜类衍生物
Jie-Wei Wu,Chun-Ping Tang,Sheng Yao et al.
Jie-Wei Wu et al.
Dicarabrols B and C (1 and 2), two new carabrane sesquiterpenoid dimers, along with one new carabrane sesquiterpenoid (3) were isolated from the whole plant of Carpesium abrotanoides L. Their full structures were established by extensive an...
A target lipidomics approach to investigate the acute inflammatory irritation induced by indolealkylamines from Chansu water fraction in rats [0.03%]
采用靶向脂质组学方法研究蟾酥水提部分中的吲哚烷胺对大鼠急性炎症刺激的影响
Xin Yang,Wu-Yue Chen,Yan Gong et al.
Xin Yang et al.
Chansu has demonstrated adverse reactions in clinical settings, which is associated with its toxicity and limits its clinical applications. But there are methodological limitations for drug safety evaluation. In the current study, ultra-hig...
Discovery of Eucalyptin C, derived from the fruits of Eucalyptus globulus Labill., as a novel selective PI3Kγ inhibitor for immunosuppressive treatment [0.03%]
来自Eucalyptus globulus Labill.果实的Eucalyptin C作为新型的选择性PI3Kγ抑制剂在免疫抑制治疗中的发现
Xiao-Long Hu,Wei Shen,Rong Wang et al.
Xiao-Long Hu et al.
The fruits of Eucalyptus globulus Labill. are known to have a plenty of medicinal properties, such as anti-tumor, anti-inflammatory, and immunosuppressive activity. Our previous study found that the phloroglucinol-sesquiterpene adducts in t...
Immunomodulatory effects of flazin from Crassostrea sikamea on splenic lymphocytes of Sprague-Dawley rats [0.03%]
长棘美人蚝多糖对Sprague-Dawley大鼠脾淋巴细胞的免疫调节作用
Ying Kong,Li-Hua Wang,Lei Liu et al.
Ying Kong et al.
Crassostrea sikamea (C.sikamea) is an important edible and medicinal seafood in China. In the present study, a compound named flazin was separated and identified from the ethyl acetate extract of C.sikamea (EAECs) for the first time. In add...
Anti-anaphylactic potential of benzoylpaeoniflorin through inhibiting HDC and MAPKs from Paeonia lactiflora [0.03%]
白芍中苯甲酰芍药苷通过抑制组胺解氨酶和丝裂原活化蛋白激酶来实现抗过敏的潜力
Wan-Chao Zhong,En-Can Li,Rui-Rui Hao et al.
Wan-Chao Zhong et al.
Guided by cell-based anti-anaphylactic assay, eighteen cage-like monoterpenoid glycosides (1-18) were obtained from the bioactive fraction of P. lactiflora extract. Among these, compounds 1, 5, 6, 11, 12, 15, and 17 significantly reduced th...
The anti-neoplastic activities of aloperine in HeLa cervical cancer cells are associated with inhibition of the IL-6-JAK1-STAT3 feedback loop [0.03%]
Aloperine在HeLa宫颈癌细胞中的抗肿瘤活性与IL-6-JAK1-STAT3反馈环的抑制有关
Yao-Dong Chen,Fang-Yu Cai,Yu-Ze Mao et al.
Yao-Dong Chen et al.
Cervical cancer (CC) is recognized as the most common neoplasm in the female reproductive system worldwide. The lack of chemotherapeutic agents with outstanding effectiveness and safety severely compromises the anti-cipated prognosis of pat...
Jia-Rui Zhang,Xuan Ouyang,Chi Hou et al.
Jia-Rui Zhang et al.
Pulmonary hypertension (PH) is a severe pathophysiological condition characterized by pulmonary artery remodeling and continuous increases in pulmonary artery pressure, which may eventually develop to right heart failure and death. Although...
Huan Xia,Gui-Yang Xia,Ling-Yan Wang et al.
Huan Xia et al.
In a continuing search for biological natural products with structure diversity from traditional Chinese herbs, five new sesquineolignans (1-5) were isolated from an ethyl acetate extract of the twigs of Litsea cubeba. Their structures were...