Mechanisms of Compound Kushen Injection for the treatment of bladder cancer based on bioinformatics and network pharmacology with experimental validation [0.03%]
基于生物信息学和网络药理学的复方苦参注射液抗膀胱癌作用机制研究及实验验证
Li-Hui Zhang,Wan-Ying Zhang,Jia-Ming Xiong et al.
Li-Hui Zhang et al.
Bladder cancer is the most common malignancy of the urinary system. Compound Kushen Injection (CKI) is a Chinese medicinal preparation that has been widely used in the treatment of various types of cancers in the past two decades. However, ...
Screening of the ubiquitin-proteasome system activators for anti-Alzheimer's disease by the high-content fluorescence imaging system [0.03%]
基于高内涵荧光成像系统的泛素-蛋白酶体系统激活剂筛选及其抗阿尔茨海默病活性研究
Yi-Ling Wang,Jing You,Jing-Jie Cao et al.
Yi-Ling Wang et al.
Ubiquitin-proteasome system (UPS) plays an important role in neurodegenerative diseases, such as Alzheimer's disease (AD), Parkinson's disease (PD), and Huntington's disease (HD). The discovery of UPS activators for anti-neurodegenerative d...
Luteoloside protects the vascular endothelium against iron overload injury via the ROS/ADMA/DDAH II/eNOS/NO pathway [0.03%]
黄酮甘草素通过ROS/ADMA/DDAH II/eNOS/NO信号通路保护铁过载引起的血管内皮细胞损伤
Shu-Ping Chen,Tian-Hong Hu,Qing Zhou et al.
Shu-Ping Chen et al.
Iron overload injury is considered to be a part of blood stasis syndrome of arthralgia in traditional Chinese medicine. Its primary therapies include clearing heat and detoxification, activating blood circulation, and removing blood stasis....
Gang Chen,Di Zhou,Cheng-Min Wang et al.
Gang Chen et al.
Natural products (NPs), especially those from traditional herbal medicines, can evidently modulate human gene expression at multiple levels, leading to a wide diversity of bioactivities. Although numerous bio-functions of NPs for human body...
Development of an eco-friendly and fast HPLC method for quantitative analysis of four nucleosides in Cordyceps and related products [0.03%]
一种用于冬虫夏草及相关产品中四种核苷类成分定量分析的环保型快速HPLC法的发展研究
Zheng-Ming Qian,Zi Wu,Qi Huang et al.
Zheng-Ming Qian et al.
An eco-friendly and fast HPLC method was developed for the determination of adenosine, inosine, guanosine and uridine in Cordyceps and related products (fermented mycelia of Hirsutella sinensis andPaecilomyces hepiali). The sample was ultra...
Transcriptional profiling and network pharmacology analysis identify the potential biomarkers from Chinese herbal formula Huosu Yangwei Formula treated gastric cancer in vivo [0.03%]
基于活体胃癌模型的归脾汤复方潜在治疗靶点及生物标志物研究
Sheng-Quan Fang,Yue-Han Liu,Kun-Peng Zhao et al.
Sheng-Quan Fang et al.
Huosu Yangwei (HSYW) Formula is a traditioanl Chinese herbal medicine that has been extensively used to treat chronic atrophic gastritis, precancerous lesions of gastric cancer and advanced gastric cancer. However, the effective compounds o...
Transcriptome sequencing and metabolome analysis reveal the mechanism of Shuanghua Baihe Tablet in the treatment of oral mucositis [0.03%]
transcriptome测序及代谢组学分析揭示双黄百合片治疗口腔黏膜炎的作用机制
Qi-Shun Geng,Rui-Juan Liu,Zhi-Bo Shen et al.
Qi-Shun Geng et al.
Oral mucositis (OM) caused by cancer therapy is the most common adverse reaction in the radiotherapy of head and neck tumors. In severe cases, it can lead to the interruption of treatment, which affects the control of the disease and the qu...
Distinctive quality control method for solid-state fermented Isaria cicadae from strain Ic-17-7 and application in a rat model of type 2 diabetes [0.03%]
一种源自蝉拟青霉Ic-17-7菌株的固体发酵全虫质量控制方法及其在2型糖尿病模型中的应用
Chang-Sheng Sun,Yu-Qin Wang,Zhong-Liang Zhang et al.
Chang-Sheng Sun et al.
This work was aimed to establish a quality control method for evaluating the effects on glucose and lipids of the fruiting body of Isaria cicadae Miquel from strain Ic-17-7 (Ic-17-7fb) using a rat model of type 2 diabetes (T2DM). Random amp...
Protective effect of Pai-Nong-San against AOM/DSS-induced CAC in mice through inhibiting the Wnt signaling pathway [0.03%]
帕药农方通过抑制Wnt信号通路对抗AOM/DSS诱导的CAC小鼠的保护作用研究
Meng-Meng Zhang,Deng-Ke Yin,Xue-Lin Rui et al.
Meng-Meng Zhang et al.
Pai-Nong-San (PNS), a prescription of traditional Chinese medicine, has been used for years to treat abscessation-induced diseases including colitis and colorectal cancer. This study was aimed to investigate the preventive effects and possi...
Exploring the mechanism of Buxue Yimu Pill on hemorrhagic anemia through molecular docking, network pharmacology and experimental validation [0.03%]
基于分子对接、网络药理及实验验证的补血益母颗粒治疗失血性贫血的作用机制研究
Yan Xiong,Xu-Yuan Cao,Bo-Yu Liu et al.
Yan Xiong et al.
Buxue Yimu Pill (BYP) is a classic gynecological medicine in China, which is composed of Angelica sinensis (Oliv.) Diels, Leonurus japonicus Houtt, Astragalus membranaceus (Fisch.) Bunge, Colla corii asini and Citrus reticulata Blanco. It h...