Design and synthesis of novel saponin-triazole derivatives in the regulation of adipogenesis [0.03%]
新型皂苷三氮唑衍生物调控脂肪生成的设计与合成研究
Yongsheng Fang,Zhiyun Zhu,Chun Xie et al.
Yongsheng Fang et al.
Saponins associated with Panax notoginseng (P. notoginseng) demonstrate significant therapeutic efficacy across multiple diseases. However, certain high-yield saponins face limited clinical applications due to their reduced pharmacological ...
Facilitating microglial phagocytosis by which Jiawei Xionggui Decoction alleviates cognitive impairment via TREM2-mediated energy metabolic reprogramming [0.03%]
启智活血方通过TREM2介导的代谢重编程促进小胶质细胞吞噬作用从而改善认知障碍
Wen Wen,Jie Chen,Junbao Xiang et al.
Wen Wen et al.
Triggering receptor expressed on myeloid cells 2 (TREM2)-mediated microglial phagocytosis is an energy-intensive process that plays a crucial role in amyloid beta (Aβ) clearance in Alzheimer's disease (AD). Energy metabolic reprogramming (...
Advances in the study of pharmacotherapy for addiction to naturally-derived psychoactive substances [0.03%]
天然成瘾药物治疗研究进展
Kexin Xie,Deli Xiao,Peng Xu et al.
Kexin Xie et al.
Drug addiction, a disorder characterized by chronic relapse and compulsive drug use, poses a significant threat to public safety and human health. Addictive substances can be categorized as natural, semi-synthetic, or synthetic based on the...
Combining label-free quantitative proteomics and 2D-DIGE to identify the potential targets of Sini Decoction acting on myocardial infarction [0.03%]
无标记定量蛋白质组学与二维差异凝胶电泳技术结合筛选四逆汤潜在抗心肌梗死靶点
Fei Feng,Weiyue Zhang,Yan Cao et al.
Fei Feng et al.
Sini Decoction (SNT) is a traditional formula recognized for its efficacy in warming the spleen and stomach and dispersing cold. However, elucidating the mechanism of action of SNT remains challenging due to its complex multiple components....
Profiling the chemical differences of diterpenoid alkaloids in different processed products of Aconiti Lateralis Radix Praeparata by UHPLC-LTQ-Orbitrap mass spectrometry combined with untargeted metabolomics and mass spectrometry imaging [0.03%]
结合无靶代谢组学和质谱成像的UHPLC-LTQ-Orbitrap质量测定法分析制附子不同炮制品中二萜生物碱化学差异性研究
Yang Yu,Changliang Yao,Jianqing Zhang et al.
Yang Yu et al.
Aconiti Lateralis Radix Praeparata (Fuzi) represents a significant traditional Chinese medicine (TCM) that exhibits both notable pharmacological effects and toxicity. Various processing methods are implemented to reduce the toxicity of raw ...
Diterpenoids and lignans from fossil Chinese medicinal succinum and their activity against renal fibrosis [0.03%]
琥珀化石中药成分及其抗肾纤维化活性研究
Yefei Chen,Yunfei Wang,Yunyun Liu et al.
Yefei Chen et al.
Five previously undescribed diterpenoids, named succipenoids D‒H (1‒5), along with four undescribed lignans, named succignans A‒D (6‒9), were isolated from the dichloromethane extract of Chinese medicinal succinum. Compounds 1‒5 were c...
Five new meroterpenoids from Rhododendron anthopogonoides and their anti-inflammatory activity [0.03%]
Rhododendron anthopogonoides的新倍半萜醌及其抗炎活性研究
Mengtian Li,Norbu Kelsang,Yongqin Zhao et al.
Mengtian Li et al.
Five meroterpenoids, rhodonoids K-M (1-2), daurichromene E (3), and grifolins A-B (4-5), together with seven known compounds (6-12), were isolated from Rhododendron anthopogonoides. The chemical structures of these compounds were elucidated...
Identification and biomimetic synthesis of iphionanes and cyperanes from Artemisia hedinii and their anti-hepatic fibrosis activity [0.03%]
Artemisia hedinii中依菲奥内烷和香茅烷类倍半萜的鉴定及其生物合成及抗肝纤维化活性研究
Xiaofei Liu,Xing Wang,Chunping Tang et al.
Xiaofei Liu et al.
Two novel skeleton sesquiterpenoids (1 and 6), along with four new iphionane-type sesquiterpenes (2-5) and six new cyperane-type sesquiterpenes (7-11), were isolated from the whole plant of Artemisia hedinii (A. hedinii). The two novel skel...
Natural diosmin alleviating obesity and nonalcoholic fatty liver disease by regulating the activating the AMP-activated protein kinase (AMPK) pathway [0.03%]
天然二氢杨梅素通过激活腺苷酸活化蛋白激酶信号通路缓解肥胖和非酒精性脂肪肝病
Can Liu,Siyu Hao,Mengdi Zhang et al.
Can Liu et al.
Obesity and metabolic dysfunction-associated steatotic liver disease (MASLD) are linked to numerous chronic conditions, including cardiovascular disease, atherosclerosis, chronic kidney disease, and type II diabetes. Previous research ident...
Platycodon grandiflorus polysaccharides combined with hesperidin exerted the synergistic effect of relieving ulcerative colitis in mice by modulating PI3K/AKT and JAK2/STAT3 signaling pathways [0.03%]
Platycodon grandiflorus 多糖联合柚皮素通过调节PI3K/AKT和JAK2/STAT3信号通路协同缓解溃疡性结肠炎小鼠模型的炎症反应
Yang Liu,Quanwei Sun,Xuefei Xu et al.
Yang Liu et al.
Ulcerative colitis (UC) is a chronic inflammatory disorder with a complex etiology, characterized by intestinal inflammation and barrier dysfunction. Platycodon grandiflorus polysaccharides (PGP), the primary component of Platycodon grandif...