Dysideanones F-G and dysiherbols D-E, unusual sesquiterpene quinones with rearranged skeletons from the marine sponge Dysidea avara [0.03%]
来自海绵Dysidea avara的六个重排骨架异维氏酮类新天然产物 Dysideanone F-G和Dysiherbol D-E
Hong-Yan Liu,Mi Zhou,Ru-Yi Shang et al.
Hong-Yan Liu et al.
Four new sesquiterpene quinone meroterpenoids, dysideanones F-G (1-2) and dysiherbols D-E (3-4), were isolated from the marine sponge Dysidea avara collected from the South China Sea. The new structures were elucidated by extensive analysis...
Geranyl phenyl ethers from Illicium micranthum and their anti-HBV activity [0.03%]
细辛属Micranthemum的肉桂醇衍生物及其抗乙型肝炎病毒活性研究
Yu Liu,Yun-Xia You,Li Rao et al.
Yu Liu et al.
Fourteen new geranyl phenyl ethers (1-14) along with three known compounds (15-17) were isolated from Illicium micranthum, and their structures were elucidated by comprehensive spectroscopic methods. Illimicranins A-H (1-8) were characteriz...
Molecular cloning and functional characterization of an isoflavone glucosyltransferase from Pueraria thomsonii [0.03%]
葛根异黄酮糖基转移酶的克隆及功能鉴定
Hai-Yan Duan,Jian Wang,Liang-Ping Zha et al.
Hai-Yan Duan et al.
Pueraria thomsonii has long been used in traditional Chinese medicine. Isoflavonoids are the principle pharmacologically active components, which are primarily observed as glycosyl-conjugates and accumulate in P. thomsonii roots. However, t...
Integrating 16S sequencing and metabolomics study on anti-rheumatic mechanisms against collagen-induced arthritis of Wantong Jingu Tablet [0.03%]
基于肠菌测序和代谢组学研究 WANTONG JINGJU TABLET 治疗类风湿性关节炎的作用机制探讨
Zhao-Dong Li,Fang-Yuan Qi,Fan Li
Zhao-Dong Li
Wantong Jingu Tablet (WJT), a mixture of traditional Chinese medicine, was reported to relieve the symptoms of rheumatoid arthritis (RA), but its pharmacological mechanism was not completely understood. The aim of this study was to investig...
Demethylenetetrahydroberberine protects dopaminergic neurons in a mouse model of Parkinson's disease [0.03%]
异戊基转移四氢巴马汀在帕金森病小鼠模型中的神经保护作用研究
Jing Wen,Yuan-Qiang Zhang,Dong-Qing Liu et al.
Jing Wen et al.
Parkinson's disease (PD) is a multifactorial disorder of the nervous system where a progressive loss of dopaminergic neurons exist. However, the pathogenesis of PD remains undefined, which becomes the main limitation for the development of ...
Dahuang Zhechong pills inhibit liver cancer growth in a mouse model by reversing Treg/Th1 balance [0.03%]
大黄蛰虫丸通过逆转肿瘤免疫微环境中Tregs/Th1平衡来抑制小鼠肝癌的生长
Tian-Tian Chen,Sha-Li DU,Shi-Jun Wang et al.
Tian-Tian Chen et al.
The infiltration of immune cells into the hepatocellular carcinoma microenvironment is the main reason why hepatocellular carcinoma patients are prone to carcinoma recurrence and the disease are incurable. Notably, the infiltration of Treg ...
β-Elemene induces apoptosis and autophagy in colorectal cancer cells through regulating the ROS/AMPK/mTOR pathway [0.03%]
β-艾里酚通过调节ROS/AMPK/mTOR途径诱导结直肠癌细胞凋亡和自噬
Guo-Yu Wang,Lei Zhang,Ya-Di Geng et al.
Guo-Yu Wang et al.
β-Elemene is an effective anti-cancer ingredient extracted from the genus Curcuma (Zingiberaceae familiy). In the present study, we demonstrated that β-elemene inhibited the proliferation of colorectal cancer cells and induced cell cycle ...
Diversity-oriented synthesis of marine sponge derived hyrtioreticulins and their anti-inflammatory activities [0.03%]
来源于海洋海绵的Hyrtioreticulins的多样性导向合成及其抗炎活性研究
Bo-Ru Chen,Cheng-Long Gao,Jin Liu et al.
Bo-Ru Chen et al.
Diversity-oriented synthesis is aimed to increase the chemical diversity of target natural products for extensive biological activity evaluation. Indole ring is an important functional group in a large number of drugs and other biologically...
GKK1032B from endophytic Penicillium citrinum induces the apoptosis of human osteosarcoma MG63 cells through caspase pathway activation [0.03%]
内生青霉菌中的GKK1032B通过激活半胱氨酸凋亡酶途径诱导人成骨肉瘤MG63细胞凋亡
Na Liu,Mei-Na Song,Qian-Qian Zhang et al.
Na Liu et al.
Chemical investigation of the culture extract of an endophytic Penicillium citrinum from Dendrobium officinale, afforded nine citrinin derivatives (1-9) and one peptide-polyketide hybrid GKK1032B (10). The structures of these compounds were...
A network pharmacology-based strategy for predicting the protective mechanism of Ginkgo biloba on damaged retinal ganglion cells [0.03%]
基于网络药理学的预测银杏叶对损伤视网膜神经节细胞保护机制的策略研究
Hua Yu,Li-Hong Dong,Yan Zhang et al.
Hua Yu et al.
Hallmarks of the pathophysiology of glaucoma are oxidative stress and apoptotic death of retinal ganglion cells (RGCs). Ginkgo biloba extract (EGb) with multi-target, multi-pathway functions has been reported to exert positive pharmacologic...