New anti-pulmonary fibrosis prenylflavonoid glycosides from Epimedium koreanum [0.03%]
朝鲜淫羊藿抗肺纤维化黄烷醇苷类成分的研究
Yu-Dan Zhao,Xin Zhang,Wan-Yue Yang et al.
Yu-Dan Zhao et al.
Four new prenylflavonoid glycosides, namely koreanoside H-K (1-4), together with eleven known ones (5-15) were isolated from the leaves of Epimedium koreanum Nakai. Their structures were elucidated by 1D NMR, 2D NMR, HR-ESI-MS, IR and UV. T...
Yong-Yue Wang,Qiu-Rong Li,Jun Chi et al.
Yong-Yue Wang et al.
Sarglanoids A-F, six new sesquiterpenoids belonging to eudesmane (1-5) and eremophilane (6) types, were isolated from the leaves of Sarcandra glabra, a famous traditional Chinese medicine (TCM). Their structures including absolute configura...
Bioactive neolignans and lignans from the roots of Paeonia lactiflora [0.03%]
毛茛科芍药属植物白芍根的倍半木脂素类成分研究
Huan Xia,Jing-Fang Zhang,Ling-Yan Wang et al.
Huan Xia et al.
Two new neolignans and one new lignan (1-3) were obtained from the roots of Paeonia lactiflora. Their structures were unambiguously elucidated based on extensive spectroscopic analysis, single-crystal X-ray crystallography, and the calculat...
Two cardenolide glycosides from the seed fairs of Asclepias curassavica and their cytotoxic activities [0.03%]
从阿斯佩里亚库拉萨维卡种子中分离出两种夹竹桃糖苷及其细胞毒活性
Ai-Jia Ji,Qing Ma,Mu-Yan Kong et al.
Ai-Jia Ji et al.
Two cardenolide glycosides, corotoxigenin 3-O-[β-D-glucopyranosyl-(1→4)-6-deoxy-β-D-glucopyranoside] (1) and coroglaucigenin 3-O-[β-D-glucopyranosyl-(1→4)-6-deoxy-β-D-glucopyranoside] (2), were isolated from the seed fairs of Asclepia...
Heme peroxidases are responsible for the dehydrogenation and oxidation metabolism of harmaline into harmine [0.03%]
血红素过氧化物酶负责 harmaline 至 harmine 的去氢和氧化代谢作用
You-Xu Wang,Ning Cao,Hui-Da Guan et al.
You-Xu Wang et al.
Harmaline and harmine are β-carboline alkaloids with effective pharmacological effects. Harmaline can be transformed into harmine after oral administration. However, enzymes involved in the metabolic pathway remain unclear. In this study, ...
Protective effects of Wuwei Xiaodu Drink against chronic osteomyelitis through Foxp3+CD25+CD4+ Treg cells via the IL-2/STAT5 signaling pathway [0.03%]
五味消毒饮通过调控Foxp3⁺CD25⁺CD4⁺Treg细胞的IL-2/STAT5信号通路防治慢性骨髓炎的作用机制研究
Kai Huang,Hai-Yong Ren,Bing-Yuan Lin et al.
Kai Huang et al.
To explore the effectiveness and safety of a Chinese medicinal decoction Wuwei Xiaodu Drink (WWXDD) in inhibiting chronic osteomyelitis via regulatory T cells signaling. The effective constitutes of WWXDD and osteomyelitis related genes wer...
Sinkihwan-gamibang ameliorates puromycin aminonucleoside-induced nephrotic syndrome [0.03%]
Sinkihwan-gamibang治疗博来霉素氨聚糖诱导的肾病综合征
Hyeon Kyoung Lee,Youn Jae Jang,Se Won Na et al.
Hyeon Kyoung Lee et al.
Nephrotic syndrome (NS) is a kidney disease characterized by hypertriglyceridemia, massive proteinuria, hypo-albuminemia and peripheral edema. Sinkihwan-gamibang (SKHGMB) was recorded in a traditional Chinese medical book named "Bangyakhapp...
Effective fraction from Simiao Wan prevents hepatic insulin resistant by inhibition of lipolysis via AMPK activation [0.03%]
基于AMPK激活抑制脂解的有效组分防治肝胰岛素抵抗的作用研究
Qi-Xin Jiang,Yi-Meng Chen,Jing-Jie Ma et al.
Qi-Xin Jiang et al.
Simiao Wan (SMW) is a traditional Chinese formula, including Atractylodis Rhizoma, Achyranthis Bidentatae Radix, Phellodendri Chinensis Cortex and Coicis Semen at the ratio of 1:1:2:2. It can be used to the treatment of diabetes. However, i...
Old fusidane-type antibiotics for new challenges: Chemistry and biology [0.03%]
旧有的伏丝地南型抗生素应对新挑战：化学及生物学研究
Chuan Tian,Ke Wang,Xuan Zhang et al.
Chuan Tian et al.
The spread of antibiotic-resistant bacteria and exhausted drug leads render some infections untreatable now and in the future. To deal with these "new challenges", scientists tend to re-pick up "old antibiotics". Fusidane-type antibiotics h...
Three new ursane-type triterpenoids from Rosmarinus officinalis and their biological activities [0.03%]
牻牛儿菊素类化合物玫瑰mary的新倍半萜及其生物活性研究
Xiang-Jian Zhong,Na Zhou,Xin Wang et al.
Xiang-Jian Zhong et al.
Three new ursane-type triterpenoids, 3-oxours-12-en-20, 28-olide (1), 3β-hydroxyurs-12-en-20, 28-olide (2) and 3β-hydroxyurs-11, 13(18)-dien-20, 28-olide (3), were isolated from a potent anti-inflammatory and antibacterial fraction of the...