Identification of multi-target anti-cancer agents from TCM formula by in silico prediction and in vitro validation [0.03%]
基于计算预测与体外验证的中药方多靶抗肿瘤成分识别研究
Bao-Yue Zhang,Yi-Fu Zheng,Jun Zhao et al.
Bao-Yue Zhang et al.
Cancer is a complex disease associated with multiple gene mutations and malignant phenotypes, and multi-target drugs provide a promising therapy idea for the treatment of cancer. Natural products with abundant chemical structure types and r...
Anti-inflammatory effects of Abelmoschus manihot (L.) Medik. on LPS-induced cystitis in mice: potential candidate for cystitis treatment based on classic use [0.03%]
Abelmoschus manihot(L.)Medik的抗炎作用：基于经典用途的小鼠内毒素性膀胱炎治疗候选药物研究
Su Zhou,Kai-Kai Fan,Li-Fei Gu et al.
Su Zhou et al.
Abelmoschus manihot (L.) Medik. (A. manihot) is a traditional Chinese herbal medicine with a variety of pharmacological properties. It was first recorded in Jiayou Materia Medica dating back to the Song dynasty to eliminate urinary tract ir...
Synthesis, and anti-inflammatory activities of gentiopicroside derivatives [0.03%]
Gentiposide衍生物的合成及其抗炎活性研究
Qi-Li Zhang,Peng-Fei Xia,Xue-Jing Peng et al.
Qi-Li Zhang et al.
A series of 26 novel derivatives have been synthesized through structural modification of gentiopicroside, a lead COX-2 inhibitor. And their in vivo and in vitro anti-inflammatory activities have been investigated. The in vitro anti-inflamm...
Polyhydroxylated eudesmane sesquiterpenoids and sesquiterpenoid glucoside from the flower buds of Tussilago farfara [0.03%]
款冬花芽中倍半萜及其苷类成分的研究
Yu-Peng Li,Kang Yang,Hui Meng et al.
Yu-Peng Li et al.
Chemical fractionation of the n-BuOH partition, which was generated from the EtOH extract of the flower buds of Tussilago farfara, afforded a series of polar constituents including four new sesquiterpenoids (1-4), one new sesquiterpenoid gl...
EGCG and ECG induce apoptosis and decrease autophagy via the AMPK/mTOR and PI3K/AKT/mTOR pathway in human melanoma cells [0.03%]
EGCG和ECG通过AMPK/mTOR和PI3K/AKT/mTOR途径诱导人黑素瘤细胞凋亡并降低自噬水平
Bing-Xin DU,Pei Lin,Jun Lin
Bing-Xin DU
Catechins have been proven to exert antitumor effects in different kinds of cancers. However, the underlying mechanisms have not been completely clarified yet. This study aimed to assess the effects and mechanisms of (-)-epigallocatechin-3-...
Study on the mechanism of Wuzi-Yanzong-Wan-medicated serum interfering with the mitochondrial permeability transition pore in the GC-2 cell induced by atractyloside [0.03%]
五子衍宗丸药效血清干预苍术苷诱导的GC-2细胞线粒体过渡孔通道机制研究
De-Ling Wu,Tong-Sheng Wang,Hong-Juan Liu et al.
De-Ling Wu et al.
Wuzi-Yanzong-Wan (WZYZW) is a classic prescription for male infertility. Our previous investigation has demonstrated that it can inhibit sperm apoptosis via affecting mitochondria, but the underlying mechanisms are unclear. The purpose of t...
Bear bile powder attenuates senecionine-induced hepatic sinusoidal obstruction syndrome in mice [0.03%]
熊胆粉可改善毒芹碱所致小鼠肝窦阻塞综合征
Kai-Yuan Jiang,Yi Zhang,Xuan-Ling Ye et al.
Kai-Yuan Jiang et al.
Hepatic sinusoidal obstruction syndrome (HSOS) via exposure to pyrrolizidine alkaloids (PAs) is with high mortality and there is no effective treatment in clinics. Bear bile powder (BBP) is a famous traditional animal drug for curing a vari...
Panax notoginseng saponins prevent colitis-associated colorectal cancer via inhibition IDO1 mediated immune regulation [0.03%]
三七总皂苷通过抑制IDO1介导的免疫调节预防结肠炎相关结直肠癌
Xue-Ming Li,Ding-Yi Yuan,Ya-Hui Liu et al.
Xue-Ming Li et al.
Colorectal cancer (CRC) is the third most lethal cancer and leading cause of cancer mortality worldwide. A key driver of CRC development is colon inflammatory responses especially in patients with inflammatory bowl disease (IBD). It has bee...
Promising natural lysine specific demethylase 1 inhibitors for cancer treatment: advances and outlooks [0.03%]
癌症治疗中具有潜力的天然组蛋白去甲基化酶LSD1抑制剂：进展与展望
Zhong-Rui Li,Meng-Zhen Gu,Xiao Xu et al.
Zhong-Rui Li et al.
Lysine specific demethylase 1 (LSD1), a transcriptional corepressor or coactivator that serves as a demethylase of histone 3 lysine 4 and 9, has become a potential therapeutic target for cancer therapy. LSD1 mediates many cellular signaling...
Design and semisynthesis of oleanolic acid derivatives as VEGF inhibitors: Inhibition of VEGF-induced proliferation, angiogenesis, and VEGFR2 activation in HUVECs [0.03%]
齐墩果酸衍生物作为血管内皮生长因子抑制剂的设计与半合成：对HUVEC增殖、新生血管生成及VEGFR2激活的抑制作用研究
Ning Meng,Hong-Xu Xie,Jia-Rong Hou et al.
Ning Meng et al.
Angiogenesis inhibitors targeting the VEGF signaling pathway are developed into drugs for the treatment of vaious diseases, such as cancer, rheumatoid arthritis, and age-related macular degeneration. Recent studies have revealed that oleano...