Tetracycline natural products: discovery, biosynthesis and engineering [0.03%]
四环素类天然产物：发现、生物合成及工程改造
Haiyan Wang,Lijun Wang,Keqiang Fan et al.
Haiyan Wang et al.
Tetracycline (TC) natural products possess a variety of remarkable bioactivities and diverse structures. They are an important and fertile source for developing novel drugs. As one of the most successful drug families, TC antibiotics have b...
Junze Ren,Yu Wu,Zhanpin Zhu et al.
Junze Ren et al.
Plant diterpenoids are widely distributed and abundant natural products with diverse structures and functions in nature, which have been commonly used in pharmaceutical, agricultural and industrial production. In recent years, plant diterpe...
Covalent flavoproteins: types, occurrence, biogenesis and catalytic mechanisms [0.03%]
共价黄素蛋白：类型、发生、生物合成和催化机制
Minjun Wang,Wenyuan Zhang,Nan Wang
Minjun Wang
Flavoproteins are proteins that contain a nucleic acid derivative of riboflavin: flavin adenine dinucleotide (FAD) or flavin mononucleotide (FMN). Flavoproteins are involved in a wide array of biological processes, such as photosynthesis, D...
Wenyu DU,Qian Yang,Huimin Xu et al.
Wenyu DU et al.
Sesquiterpenoids are comprised of three C5 units and derived from farnesyl diphosphate. In these C15 family of terpenoids, drimane-type sesquiterpenoids are unique as their chemical structure of decahydronaphthalene along with the methyl gr...
Combining microbial and chemical syntheses for the production of complex natural products [0.03%]
结合微生物合成和化学合成生产复杂天然产物
Haili Zhang,Xiaoyu Tang
Haili Zhang
Nature, a rich source of bioactive natural products, serves as a massive pool of drug candidates for the pharmaceutical industry. However, the supply of these structurally complex chemicals is costly as most of the natural products are scar...
Targeting the biological activity and biosynthesis of hyperforin: a mini-review [0.03%]
穿心莲内酯的生物活性和生物合成的小结综述
Shuqin Liu,Beilei Yu,Jungui Dai et al.
Shuqin Liu et al.
Hyperforin is a representative polycyclic polyprenylated acylphloroglucinols (PPAPs) that exerts a variety of pharmacological activities. The complete biosynthesis pathway of hyperforin has not been elucidated due to its complex structure a...
New prenylated flavonoid glycosides derived from Epimedium wushanense by β-glucosidase hydrolysis and their testosterone production-promoting effects [0.03%]
淫羊藿茋类黄酮苷元的葡萄糖醛酸结合物的体外合成及其促生精作用研究
Xin-Guang Sun,Xu Pang,Hai-Zhen Liang et al.
Xin-Guang Sun et al.
Six new prenylated flavonoid glycosides, including four new furan-flavonoid glycosides wushepimedoside A-D (1-4) and two new prenyl flavonoid derivatives wushepimedoside E-F (5-6), and one know analog epimedkoreside B (7) were isolated from...
Diverse sesquiterpenoids from Litsea lancilimba Merr. with potential neuroprotective effects against H2O2-induced SH-SY5Y cell injury [0.03%]
Litsea lancilimba Merr.倍半萜类化合物的多样性及其潜在的神经保护活性研究
Yi-Jie Zhang,Ming Bai,Jia-Yi Li et al.
Yi-Jie Zhang et al.
Five undescribed sesquiterpenoids (1-5), and nine known sesquiterpenoids (6-14) were obtained from the fruits of Litsea lancilimba Merr. by LC-MS/MS molecular networking strategies. Litsemene A (1) possessed a unique 8-member ring through u...
Identification of a cytochrome P450 from Tripterygium hypoglaucum (Levl.) Hutch that catalyzes polpunonic acid formation in celastrol biosynthesis [0.03%]
从大花清风藤中鉴定出一种黄酮羟基化的细胞色素P450酶TrhCYP91E26参与鬼臼毒素生物合成中的Polpunonic酸的形成
Xiao-Chao Chen,Yun Lu,Yuan Liu et al.
Xiao-Chao Chen et al.
Tripterygium hypoglaucum (Levl.) Hutch, a traditional Chinese medicinal herb with a long history of use, is widely distributed in China. One of its main active components, celastrol, has great potential to be developed into anti-cancer and ...
The combination of EGCG with warfarin reduces deep vein thrombosis in rabbits through modulating HIF-1α and VEGF via the PI3K/AKT and ERK1/2 signaling pathways [0.03%]
儿茶素与华法林联合应用通过调节PI3K/AKT和ERK1/2信号途径中HIF-1α和VEGF的表达降低兔深静脉血栓形成发生率
Yan Li,Jing-Ping Ge,Ke Ma et al.
Yan Li et al.
Deep venous thrombosis (DVT) poses a major challenge to public health worldwide. Endothelial cell injury evokes inflammatory and oxidative responses that contribute to thrombus formation. Tea polyphenol (TP) in the form of epigallocatechin-...