Protective mechanisms of Leontopodium leontopodioides extracts on lipopolysaccharide-induced acute kidney injury viathe NF-κB/NLRP3 pathway [0.03%]
Leontopodium leontopodioides提取物通过NF-κB/NLRP3通路对脂多糖诱导的急性肾损伤的保护机制
Xue Bai,Qianqian Ma,Qi Li et al.
Xue Bai et al.
Sepsis-induced uncontrolled systemic inflammatory response syndrome (SIRS) is a critical cause of multiple organ failure. Acute kidney injury (AKI) is one of the most serious complications associated with an extremely high mortality rate in...
Bavachin induces apoptosis in colorectal cancer cells through Gadd45a via the MAPK signaling pathway [0.03%]
Bavachin通过MAPK信号通路经由Gadd45a诱导结肠直肠癌细胞凋亡
Mengru Wang,Baopeng Tian,Jie Shen et al.
Mengru Wang et al.
Bavachin is a dihydroflavonoid compound isolated from Psoralea corylifolia, and exhibits anti-bacterial, anti-inflammatory, anti-tumor and lipid-lowering activities. Recent attention has gradually drawn on bavachin-induced apoptosis in many...
Modulation of type I interferon signaling by natural products in the treatment of immune-related diseases [0.03%]
天然产物通过调节I型干扰素信号转导治疗免疫相关疾病中的作用
Shuo Li,Guifang Fan,Xiaojiaoyang Li et al.
Shuo Li et al.
Type I interferon (IFN) is considered as a bridge between innate and adaptive immunity. Proper activation or inhibition of type I IFN signaling is essential for host defense against pathogen invasion, tumor cell proliferation, and overactiv...
Bioactive peptides from scorpion venoms: therapeutic scaffolds and pharmacological tools [0.03%]
蝎毒中的生物活性肽：治疗支架和药理工具
Kamau Peter Muiruri,Jian Zhong,Bing Yao et al.
Kamau Peter Muiruri et al.
Evolution and natural selection have endowed animal venoms, including scorpion venoms, with a wide range of pharmacological properties. Consequently, scorpions, their venoms, and/or their body parts have been used since time immemorial in t...
Targeted isolation and identification of bioactive pyrrolidine alkaloids from Codonopsis pilosula using characteristic fragmentation-assisted mass spectral networking [0.03%]
利用特征裂解辅助的质谱网络技术从党参中靶向分离鉴定吡咯啶生物碱
Xiyang Tang,Cailian Fan,Jiaxing Zeng et al.
Xiyang Tang et al.
Codonopsis pilosula (CP), a well-known food medicine homology plant, is commonly used in many countries. In our preliminary study, a series of pyrrolidine alkaloids with high MS responses were detected as characteristic absorbed constituent...
Five Rutaceae family ethanol extracts alleviate H2O2 and LPS-induced inflammation via NF-κB and JAK-STAT3 pathway in HaCaT cells [0.03%]
五种芸香科乙醇提取物通过NF-κB和JAK-STAT3途径缓解HaCaT细胞中H2O2和LPS引起的炎症反应
Mengsa Hong,Kun Xiao,Pei Lin et al.
Mengsa Hong et al.
This study was designed to investigate the effects of five Rutaceae family ethanol extracts (FRFEE): Citrus medica Linn (CML), Citrus aurantium L. Cv. Daidai (CAD), Citrus medica Linn. var. sarcodactylis (Noot.) Swingle (CMS),Citrus sinensi...
Chemical composition-based characterization of the anti-allergic effect of Guominkang Formula on IgE-mediated mast cells activation and passive cutaneous anaphylaxis [0.03%]
基于化学成分抗过敏效应的桂敏康方剂对IgE介导的肥大细胞激活和被动皮肤过敏反应的作用研究
Ding Tang,Chen Wang,Qianying Gan et al.
Ding Tang et al.
Guominkang (GMK), a Chinese medicine formula, has been used to treat allergic diseases in clinical settings for many years. To evaluate the antiallergic effect and molecular mechanism of action of GMK extract, RBL-2H3 cell models and passiv...
Houttuynia cordata polysaccharides alleviate ulcerative colitis by restoring intestinal homeostasis [0.03%]
鱼腥草多糖通过恢复肠道稳态缓解溃疡性结肠炎
Lifeng Cen,Tong Yi,Yuanzhen Hao et al.
Lifeng Cen et al.
Houttuynia cordata is traditionally used as phytoantibiotics for treating lung disease in China. Houttuynia cordata polysaccharides (HCPs) have been reported to alleviate influenza virus-induced intestinal and lung immune injury by regulati...
Er-xian ameliorates myocardial ischemia-reperfusion injury in rats through RISK pathway involving estrogen receptors [0.03%]
二仙通过涉及雌激素受体的RISK通路减轻大鼠心肌缺血-再灌注损伤
Mingmin Qiang,Jiping Hao,Huihui Liu et al.
Mingmin Qiang et al.
Curculigo orchioides (CUR) and Epimedium (EPI) are traditional Chinese medicines with estrogen-like biological activity, called Xianmao and Xianlingpi (Er-xian) in Chinese. However, whether Er-xian exerts protective effects on myocardial is...