Cyasterone inhibits IL-1β-mediated apoptosis and inflammation via the NF-κB and MAPK signaling pathways in rat chondrocytes and ameliorates osteoarthritisin vivo [0.03%]
赛斯特酮通过NF-κB和MAPK信号通路抑制IL-1β介导的软骨细胞凋亡及炎症反应并改善体内骨关节炎病理进程
Li Teng,Yue Shen,Yuhan Qu et al.
Li Teng et al.
Osteoarthritis is a prevalent global joint disease, which is characterized by inflammatory reaction and cartilage degradation. Cyasterone, a sterone derived from the roots of Cyathula officinalis Kuan, exerts protective effect against sever...
Screening the effective components in treating dampness stagnancy due to spleen deficiency syndrome and elucidating the potential mechanism of Poria water extract [0.03%]
筛选脾虚湿阻证有效成分及茯苓水提物治疗作用机制探讨
Huijun Li,Dandan Zhang,Tianhe Wang et al.
Huijun Li et al.
Poria is an important medicine for inducing diuresis to drain dampness from the middle energizer. However, the specific effective components and the potential mechanism of Poria remain largely unknown. To identify the effective components a...
Steroids and dihydroisocoumarin glycosides from Xylaria sp. by the one strain many compounds strategy and their bioactivities [0.03%]
一株多产物策略从Xylaria孢子中发现的类固醇和茋類糖苷及其生物活性研究
Dong Gan,Chenzhe Li,Yan Shu et al.
Dong Gan et al.
The fungus Xylaria sp. KYJ-15 was isolated from Illigera celebica. Based on the one strain many compounds (OSMAC) strategy, the strain was fermented on potato and rice solid media, respectively. As a result, two novel steroids, xylarsteroid...
Antimicrobial indole alkaloids from Tabernaemontana corymbosa [0.03%]
Tabernaemontana corymbosa的抗菌吲哚生物碱类化合物研究
Kun Fan,Lanchun Zhang,Bangyin Tan et al.
Kun Fan et al.
Four unreported monoterpene indole alkaloids, tabernaecorymines B-E (1-4), together with twenty-one known indole alkaloids (5-25) were obtained from the stem bark of Tabernaemontana corymbosa. Their structures and absolute configurations we...
Berberine targets the electron transport chain complex I and reveals the landscape of OXPHOS dependency in acute myeloid leukemia with IDH1 mutation [0.03%]
小檗碱通过作用于电子传递链复合物I揭示了IDH1突变急性髓系白血病的氧化磷酸化依赖图景
Zhe Huang,Yunfu Shen,Wenjun Liu et al.
Zhe Huang et al.
Metabolic reprogramming, a newly recognized trait of tumor biology, is an intensively studied prospect for oncology medicines. For numerous tumors and cancer cell subpopulations, oxidative phosphorylation (OXPHOS) is essential for their bio...
Stigmasterol protects human brain microvessel endothelial cells against ischemia-reperfusion injury through suppressing EPHA2 phosphorylation [0.03%]
山柰酚通过抑制EPHA2磷酸化保护人脑微血管内皮细胞免受缺血再灌注损伤
Suping Li,Fei Xu,Liang Yu et al.
Suping Li et al.
Stigmasterol is a plant sterol with anti-apoptotic, anti-oxidative and anti-inflammatory effect through multiple mechanisms. In this study, we further assessed whether it exerts protective effect on human brain microvessel endothelial cells...
Marsdenia tenacissima injection induces the apoptosis of prostate cancer by regulating the AKT/GSK3β/STAT3 signaling axis [0.03%]
鸡血藤总皂苷通过调控AKT/GSK3β/STAT3信号轴诱导前列腺癌细胞凋亡
Xiaolan Li,Songhua He,Wei Liang et al.
Xiaolan Li et al.
Marsdenia tenacissima injection, a standard Marsdenia tenacissima extract (MTE), has been approved as an adjuvant therapeutic agent for various cancers. Our previous study showed that MTE inhibited the proliferation and metastasis of prosta...
Flavonoids from the roots and rhizomes of Sophoratonkinensis and their in vitro anti-SARS-CoV-2 activity [0.03%]
Sophoratanキンセンの根と根茎由来のフラボノイドおよびその抗SARS-CoV-2活性
Zhuo Li,Hang Xie,Chunping Tang et al.
Zhuo Li et al.
Acute respiratory infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) had caused a global pandemic since 2019, and posed a serious threat to global health security. Traditional Chinese medicine (TCM) has played ...
Seven drimane-type sesquiterpenoids from an earwig-associated Aspergillus sp [0.03%]
一种耳虫相关曲霉菌中的七个drimane型倍半萜类化合物
Khan Salman,Hongjie Zhu,Ziqian Sun et al.
Khan Salman et al.
Drimane-type sesquiterpenoids are widely distributed in fungi. From the ethyl acetate extract of the earwig-derived Aspergillus sp. NF2396, seven new drimane-type sesquiterpenoids, named drimanenoids A-G (1-7), were isolated. Their structur...