Polygalacin D inhibits the growth of hepatocellular carcinoma cells through BNIP3L-mediated mitophagy and endogenous apoptosis pathways [0.03%]
聚甲素D通过BNIP3L介导的线粒体自噬和内源性凋亡途径抑制肝癌细胞增殖
Fulong Nan,Wenlong Nan,Zhongjie Yu et al.
Fulong Nan et al.
Platycodon grandiflorum (Jacq.) A. DC. is a famous medicinal plant commonly used in East Asia. Triterpene saponins isolated from P. grandiflorum are the main biologically active compounds, among which polygalacin D (PGD) has been reported t...
Chang Wei Qing Decoction enhances the anti-tumor effect of PD-1 inhibitor therapy by regulating the immune microenvironment and gut microbiota in colorectal cancer [0.03%]
柴胡清肝汤通过调节免疫微环境及肠道菌群增强PD-1抑制剂治疗结直肠癌的抗肿瘤作用
Ting Wang,Linguangjin Wu,Shuyun Wang et al.
Ting Wang et al.
The anti-tumor effect of anti-PD-1 antibody has long been shown to be strongly related to the tumor immune microenvironment (TIME). This study aimed to mechanistically assess whether Chang Wei Qing (CWQ) Decoction can enhance the anti-tumor...
Network pharmacology approaches for research of Traditional Chinese Medicines [0.03%]
网络药理学在中药研究中的应用
Xiang Li,Ziqi Liu,Jie Liao et al.
Xiang Li et al.
Pharmacodynamics material basis and effective mechanisms are the two main issues to decipher the mechnisms of action of Traditional Chinese medicines (TCMs) for the treatment of diseases. TCMs, in "multi-component, multi-target, multi-pathw...
Zi Fei Xu,Liao-Bin Dong
Zi Fei Xu
Study on the dynamic variation of the secondary metabolites in Viscum coloratum using targeted metabolomics [0.03%]
基于目标代谢组学的槲寄生次生代谢产物动态变化研究
Ruizhen Zhang,Rong Duan,Weiqing Wang et al.
Ruizhen Zhang et al.
Viscum coloratum (Kom.) Nakai is a well-known medicinal plant. However, the optimal harvest time for V. coloratum is unknown. Few studies were performed to analyze compound variation during storage and to improve post-harvest quality contro...
Yang Li,Yajiao Jian,Fan Xu et al.
Yang Li et al.
Five new terpenoids, including two vibsane-type diterpenoids (1, 2) and three iridoid allosides (3-5), together with eight known ones, were isolated from the leaves and twigs of Viburnum odoratissimum var.sessiliflorum. Their planar structu...
Geranylated or prenylated flavonoids from Cajanus volubilis [0.03%]
牻牛儿基或异戊二烯基化黄酮类化合物从Cajanus volubilis中分离鉴定到的新化合物
Li Rao,Yu Su,Qian He et al.
Li Rao et al.
Five new flavonoid derivatives, cajavolubones A-E (1-5), along with six known analogues (6-11) were isolated from Cajanus volubilis, and their structures were elucidated by spectroscopic analysis and quantum chemical calculations. Cajavolub...
Potentilla anserina polysaccharide alleviates cadmium-induced oxidative stress and apoptosis of H9c2 cells by regulating the MG53-mediated RISK pathway [0.03%]
蒲公英多糖通过调节MG53介导的RISK通路缓解镉诱导的H9c2细胞氧化应激和凋亡
Lixia Zhao,Ju Cheng,Di Liu et al.
Lixia Zhao et al.
Oxidative stress plays a crucial role in cadmium (Cd)-induced myocardial injury. Mitsugumin 53 (MG53) and its mediated reperfusion injury salvage kinase (RISK) pathway have been demonstrated to be closely related to myocardial oxidative dam...
Platycodon grandiflorus polysaccharide regulates colonic immunity through mesenteric lymphatic circulation to attenuate ulcerative colitis [0.03%]
北沙参多糖通过肠系膜淋巴循环调节结肠免疫以缓解溃疡性结肠炎
Yang Liu,Yahui Dong,Wei Shen et al.
Yang Liu et al.
Platycodon grandiflorus polysaccharide (PGP) is one of the main components of P. grandiflorus, but the mechanism of its anti-inflammatory effect has not been fully elucidated. The aim of this study was to evaluate the therapeutic effect of ...
Qianjin Wenwu decoction suppresses renal interstitial fibrosis by enhancing the degradation of extracellular matrix in mice with unilateral ureteral obstruction [0.03%]
千金温脾汤通过促进细胞外基质降解抑制单侧输尿管结扎小鼠肾间质纤维化
Chengshan Jin,Xiaotian Wu,Yue You et al.
Chengshan Jin et al.
Diabetic kidney disease (DKD) is the most common complication of diabetes mellitus (DM). Qianjin Wenwu decoction (QWD), a well-known traditional Korean medicine, has been used for the treatment of DKD, with satisfactory therapeutic effects....