Lysohexaenetides A and B, linear lipopeptides from Lysobacter sp. DSM 3655 identified by heterologous expression in Streptomyces [0.03%]
通过异源表达鉴定的裂褶菌DSM 3655产线性脂肽类化合物Lysohexaenetides A和B
Qiushuang Xu,Haochen Zou,Chen Pan et al.
Qiushuang Xu et al.
Lysobacter harbors a plethora of cryptic biosynthetic gene clusters (BGCs), albeit only a limited number have been analyzed to date. In this study, we described the activation of a cryptic polyketide synthase (PKS)/nonribosomal peptide synt...
Bioassay-guided isolation of α-Glucosidase inhibitory constituents from Hypericum sampsonii [0.03%]
基于生物测定的牻牛儿苗属植物 Sampson 奶牛舌草中α-葡萄糖苷酶抑制成分的研究
Linlan Tao,Shuangyu Xu,Zizhen Zhang et al.
Linlan Tao et al.
This study employed the α-glucosidase inhibitory activity model as an anti-diabetic assay and implemented a bioactivity-guided isolation strategy to identify novel natural compounds with potential therapeutic properties. Hypericum sampsoni...
Heterologous production of bioactive xenoacremone analogs in Aspergillus nidulans [0.03%]
异源产生生物活性的外源类acremonone化合物到曲霉菌中
Zhiguo Liu,Wei Li,Peng Zhang et al.
Zhiguo Liu et al.
Tyrosine-decahydrofluorene derivatives are a class of hybrid compounds that integrate the properties of polyketides and nonribosomal peptides. These compounds feature a [6.5.6] tricarbocyclic core and a para-cyclophane ether moiety in their...
Jinyinqingre Oral Liquid alleviates LPS-induced acute lung injury by inhibiting the NF-κB/NLRP3/GSDMD pathway [0.03%]
金芩清热口服液通过抑制NF-κB/NLRP3/GSDMD信号通路缓解内毒素致急性肺损伤
Shuhui Wang,Pan Lei,Ying Feng et al.
Shuhui Wang et al.
Acute lung injury (ALI) is a prevalent and severe clinical condition characterized by inflammatory damage to the lung endothelial and epithelial barriers, resulting in high incidence and mortality rates. Currently, there is a lack of safe a...
Therapeutic potential of alkaloid extract from Codonopsis Radix in alleviating hepatic lipid accumulation: insights into mitochondrial energy metabolism and endoplasmic reticulum stress regulation in NAFLD mice [0.03%]
碱性提取物的治疗潜力可减轻肝脂质蓄积 Codonopsis Radix：NAFLD小鼠线粒体能量代谢和内质网压力调节的新见解
Cailian Fan,Guan Wang,Miao Chen et al.
Cailian Fan et al.
Alkaloids are a class of naturally occurring bioactive compounds that are widely distributed in various food sources and Traditional Chinese Medicine. This study aimed to investigate the therapeutic effects and underlying mechanisms of alka...
Guijiajiao (Colla Carapacis et Plastri, CCP) prevents male infertility via gut microbiota modulation [0.03%]
龟甲胶通过调节肠道菌群防治男性不育
Wen Sheng,Wenjing Xu,Jin Ding et al.
Wen Sheng et al.
Male infertility is a significant cause of psychosocial and marital distress in approximately 50% of couples who are unable to conceive, with male factors being the underlying cause. Guijiajiao (Colla Carapacis et Plastri, CCP) is a Traditi...
Commentary on "A population of stem cells with strong regenerative potential discovered in deer antlers " [0.03%]
评论文章《角鹿角中发现具有强再生潜能的干细胞群体》
Jing Liu,Li Shao,Weihua Huang
Jing Liu
Deciphering suppressive effects of Lianhua Qingwen Capsule on COVID-19 and synergistic effects of its major botanical drug pairs [0.03%]
连花清瘟抑制新型冠状病毒的作用机制及其组分药对的协同作用研究
Yuanyuan Chen,Cheng Zhang,Ning Wang et al.
Yuanyuan Chen et al.
The COVID-19 pandemic has resulted in excess deaths worldwide. Conventional antiviral medicines have been used to relieve the symptoms, with limited therapeutic effect. In contrast, Lianhua Qingwen Capsule is reported to exert remarkable an...
Ephedra Herb extract ameliorates adriamycin-induced nephrotic syndrome in rats via the CAMKK2/AMPK/mTOR signaling pathway [0.03%]
麻黄提取物通过CAMKK2/AMPK/mTOR信号通路改善腺苷诱导的肾病综合征研究
Yuhan Zhang,Mengnan Zeng,Benke Li et al.
Yuhan Zhang et al.
This study aimed to investigate the effect and mechanisms of Ephedra Herb (EH) extract on adriamycin-induced nephrotic syndrome (NS), providing an experimental basis for the clinical treatment of NS. Hematoxylin and eosin staining, creatini...
Shen Qi Wan attenuates renal interstitial fibrosis through upregulating AQP1 [0.03%]
肾气丸通过上调AQP1治疗肾脏间质纤维化作用的研究
Yiyou Lin,Jiale Wei,Yehui Zhang et al.
Yiyou Lin et al.
Renal interstitial fibrosis (RIF) is the crucial pathway in chronic kidney disease (CKD) leading to the end-stage renal failure. However, the underlying mechanism of Shen Qi Wan (SQW) on RIF is not fully understood. In the current study, we...