Scutellaria baicalensis: a promising natural source of antiviral compounds for the treatment of viral diseases [0.03%]
防风草：一种有前景的抗病毒化合物天然来源用于治疗病毒感染性疾病
Qiuju Huang,Muyang Wang,Min Wang et al.
Qiuju Huang et al.
Viruses, the smallest microorganisms, continue to present an escalating threat to human health, being the leading cause of mortality worldwide. Over the decades, although significant progress has been made in the development of therapies an...
New di-spirocyclic labdane diterpenoids from the aerial parts of Leonurus japonicus [0.03%]
日本母亲草乙酸中的二螺环 Labsdan型二萜新化合物
Xinxin Cao,Xinxin Wang,Yu Zhang et al.
Xinxin Cao et al.
Phytochemical investigation on the ethanol extract of a well-known medicinal herb Leonurus japonicus, led to the separation of 18 labdane type diterpenoids (1-18). Through comprehensive spectroscopic analyses and quantum chemical calculatio...
Ginsenoside-Rg1 combined with a conditioned medium from induced neuron-like hUCMSCs alleviated the apoptosis in a cell model of ALS through regulating the NF-κB/Bcl-2 pathway [0.03%]
Ginsenoside-Rg1联合诱导神经元样人脐带间充质干细胞条件培养基通过调节NF-κB/Bcl-2通路缓解ALS细胞模型凋亡
Yu Huang,Huili Yang,Biying Yang et al.
Yu Huang et al.
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease affecting both upper and lower motor neurons in the brain and spinal cord. One important aspect of ALS pathogenesis is superoxide dismutase 1 (SOD1) mutant-mediated mi...
Neotuberostemonine and tuberostemonine ameliorate pulmonary fibrosis through suppressing TGF-β and SDF-1 secreted by macrophages and fibroblasts via the PI3K-dependent AKT and ERK pathways [0.03%]
新藤叶碱和藤叶碱通过PI3K依赖的AKT和ERK途径抑制巨噬细胞和成纤维细胞分泌TGF-β和SDF-1治疗肺纤维化
San Fu,Xianrui Song,Yingying Hu et al.
San Fu et al.
Activated fibroblasts and M2-polarized macrophages may contribute to the progression of pulmonary fibrosis by forming a positive feedback loop. This study was aimed to investigate whether fibroblasts and macrophages form this loop by secret...
Eucommia lignans alleviate the progression of diabetic nephropathy through mediating the AR/Nrf2/HO-1/AMPK axis in vivo and in vitro [0.03%]
杜仲胶通过体内和体外实验介导雄激素受体/核因子E2相关因子2/血红素加氧酶1/腺苷酸活化蛋白激酶轴来缓解糖尿病肾病的进展
Qi Huang,Yinfan Zhang,Yueping Jiang et al.
Qi Huang et al.
Lignans derived from Eucommia ulmoides Oliver (Eucommia lignans) inhibit the progression of inflammatory diseases, while their effect on the progression of diabetic nephropathy (DN) remained unclear. This work was designed to assess the fun...
Juncai Liu,Zhen Ge,Xiao Jiang et al.
Juncai Liu et al.
Natural products exhibit substantial impacts in the field of anti-hypoxic traetment. Hypoxia can cause altitude sickness and other negative effect on the body. Headache, coma, exhaustion, vomiting and, in severe cases, death are some of the...
Herbal medicines for insomnia through regulating 5-hydroxytryptamine receptors: a systematic review [0.03%]
调节5-羟色胺受体治疗失眠的中药系统评价
Haoran Wang,Yanqiu Gu,Rahman Khalid et al.
Haoran Wang et al.
Insomnia is a common sleep disorder without effective therapy and can affect a person's life. The mechanism of the disease is not completely understood. Hence, there is a need to understand the targets related to insomnia, in order to devel...
Shuting Xiang,Mingxi Li,Suxin Li
Shuting Xiang
Deciphering chemical and metabolite profiling of Chang-Kang-Fang by UPLC-Q-TOF-MS/MS and its potential active components identification [0.03%]
基于UPLC-Q-TOF-MS/MS的常 kang 茶化学成分及代谢组学分析及其有效成分筛选与鉴定研究
Fengge Yang,Sihao Zhang,Danmei Tian et al.
Fengge Yang et al.
Chang-Kang-Fang (CKF) formula, a Traditional Chinese Medicine (TCM) prescription, has been widely used for the treatment of irritable bowel syndrome (IBS). However, its potential material basis and underlying mechanism remain elusive. There...