Steroid and triterpenoid saponins from the rhizomes of Paris polyphylla var. stenophylla [0.03%]
Paris polyphylla var. stenophylla块根中的甾体和三萜皂苷成分研究
Jinming Hu,Yunyang Lu,Shuxian Zheng et al.
Jinming Hu et al.
Five new saponins, including three steroid saponins, paristenoids A-C (1-3), and two triterpenoid saponins, paristenoids D-E (4-5), along with four known ones (6-9) were isolated from the rhizomes of Paris polyphylla var. stenophylla. The s...
Network pharmacology and experimental validation of Maxing Shigan decoction in the treatment of influenza virus-induced ferroptosis [0.03%]
基于网络药理学和实验验证的大青龙汤治疗流感病毒诱导的铁死亡研究
Jiawang Huang,Xinyue Ma,Zexuan Liao et al.
Jiawang Huang et al.
Influenza is an acute viral respiratory infection that has caused high morbidity and mortality worldwide. Influenza A virus (IAV) has been found to activate multiple programmed cell death pathways, including ferroptosis. Ferroptosis is a no...
Paeonol reduces microbial metabolite α-hydroxyisobutyric acid to alleviate the ROS/TXNIP/NLRP3 pathway-mediated endothelial inflammation in atherosclerosis mice [0.03%]
苯乙酮酚通过减少肠道微生物代谢产物α-羟异丁酸来缓解ROS/TXNIP/NLRP3途径介导的动脉粥样硬化小鼠内皮炎症作用
Yarong Liu,Hongfei Wu,Tian Wang et al.
Yarong Liu et al.
Gut microbiota dysbiosis is an avenue for the promotion of atherosclerosis (AS) and this effect is mediated partly via the circulating microbial metabolites. More microbial metabolites related to AS vascular inflammation, and the mechanisms...
Ginkgo biloba extract protects against depression-like behavior in mice through regulating gut microbial bile acid metabolism [0.03%]
银杏叶提取物通过调节肠道微生物胆汁酸代谢来保护小鼠免受类似抑郁的行为
Junchi Zhou,Qilin Fan,Xiaoying Cai et al.
Junchi Zhou et al.
Depression is a mental disorder with high morbidity, disability and relapse rates. Ginkgo biloba extract (GBE), a traditional Chinese medicine, has a long history of clinical application in the treatment of cerebral and mental disorders, bu...
Tripterygium hypoglaucum extract ameliorates adjuvant-induced arthritis in mice through the gut microbiota [0.03%]
雷公藤内酯醇通过调控肠道菌群改善小鼠自身免疫性关节炎
Jianghui Hu,Jimin Ni,Junping Zheng et al.
Jianghui Hu et al.
Traditionally, Tripterygium hypoglaucum (Levl.) Hutch (THH) are widely used in Chinese folk to treat rheumatoid arthritis (RA). This study aimed to investigate whether the anti-RA effect of THH is related with the gut microbiota. The main c...
Biotransformation differences of ginsenoside compound K mediated by the gut microbiota from diabetic patients and healthy subjects [0.03%]
糖尿病患者和健康受试者肠道菌群介导的人参皂苷CK生物转化差异性研究
Sutianzi Huang,Li Shao,Manyun Chen et al.
Sutianzi Huang et al.
Many natural products can be bio-converted by the gut microbiota to influence pertinent efficiency. Ginsenoside compound K (GCK) is a potential anti-type 2 diabetes (T2D) saponin, which is mainly bio-transformed into protopanaxadiol (PPD) b...
Bear bile powder alleviates Parkinson's disease-like behavior in mice by inhibiting astrocyte-mediated neuroinflammation [0.03%]
熊胆粉通过抑制星形胶质细胞介导的神经炎症来缓解小鼠帕金森病样行为
Lupeng Wang,Yuyan Bai,Yanlin Tao et al.
Lupeng Wang et al.
Parkinson's disease (PD) is a common neurodegenerative disease in middle-aged and elderly people. In particular, increasing evidence has showed that astrocyte-mediated neuroinflammation is involved in the pathogenesis of PD. As a precious t...
Chuanxiong Rhizoma extracts prevent cholestatic liver injury by targeting H3K9ac-mediated and cholangiocyte-derived secretory protein PAI-1 and FN [0.03%]
川芎提取物通过组蛋白乙酰化修饰和胆管细胞分泌PAI-1及FN防治肝内胆汁淤积损伤研究
Yajing Li,Zhi Ma,Mingning Ding et al.
Yajing Li et al.
Chuanxiong Rhizoma (CX, the dried rhizome of Ligusticum wallichii Franch.), a well-known traditional Chinese medicine, is clinically used for treating cardiovascular, cerebrovascular and hepatobiliary diseases. Cholestatic liver damage is o...
Dihydroartemisinin attenuates ischemia/reperfusion-induced renal tubular senescence by activating autophagy [0.03%]
二氢青蒿素通过激活自噬来减轻缺血/再灌注所致的肾小管衰老作用
Huiling Liu,Zhou Huang,Hong Jiang et al.
Huiling Liu et al.
Acute kidney injury (AKI) is an important factor for the occurrence and development of CKD. The protective effect of dihydroartemisinin on AKI and and reported mechanism have not been reported. In this study, we used two animal models inclu...