Zeshi Sun,Shan Lin,Zhi-Li Wu et al.
Zeshi Sun et al.
Our continued works on the chemical constituents of Ginkgo biloba (G. biloba) leaves has led to the isolation of two novel phenylbutenoids (1, 2), along with five previously unidentified terpene glycosides (3-7). Among them, compounds 1 and...
Xiaolei Huang,Chengrun Tang,Xusheng Huang et al.
Xiaolei Huang et al.
In this study, 37 derivatives of phorbol esters were synthesized and their anti-HIV-1 activities evaluated, building upon our previous synthesis of 51 phorbol derivatives. 12-Para-electron-acceptor-trans-cinnamoyl-13-decanoyl phorbol deriva...
Activation of NRF2 by celastrol increases antioxidant functions and prevents the progression of osteoarthritis in mice [0.03%]
雷公藤红素通过激活NRF2增强抗氧化功能并防止小鼠骨关节炎的进展
Mingming Liu,Jiatian Guo,Jing Zhao et al.
Mingming Liu et al.
Excessive oxidative stress impairs cartilage matrix metabolism balance, significantly contributing to osteoarthritis (OA) development. Celastrol (CSL), a drug derived from Tripterygium wilfordii, has recognized applications in the treatment...
Anti-psoriasis molecular targets and active components discovery of Optimized Yinxieling Formula via affinity-purified strategy [0.03%]
优化银屑灵方抗银屑病分子靶点及活性成分的亲和纯化发现策略
Wei Wang,Lijuan Liu,Zhuo Yang et al.
Wei Wang et al.
Psoriasis, a prevalent inherited skin condition, involves an inflammatory response as a key pathogenic mechanism. The Optimized Yinxieling Formula (OYF), rooted in traditional Chinese medicine, is extensively utilized in clinical settings t...
A naturally derived small molecule compound suppresses tumor growth and metastasis in mice by relieving p53-dependent repression of CDK2/Rb signaling and the Snail-driven EMT [0.03%]
一种天然衍生的小分子化合物通过缓解p53依赖的对CDK2/Rb信号传导和Snail驱动的上皮细胞-间充质转化的抑制作用来抑制小鼠中的肿瘤生长和转移
Boxue Ren,Yang Li,Lei DI et al.
Boxue Ren et al.
The tumor suppressor protein p53 is central to cancer biology, with its pathway reactivation emerging as a promising therapeutic strategy in oncology. This study introduced LZ22, a novel compound that selectively inhibits the growth, migrat...
Recent advances in the culture-independent discovery of natural products using metagenomic approaches [0.03%]
使用宏基因组方法独立于培养发现天然产物的最新进展
Yiping Shen,Nan Liu,Zongqiang Wang
Yiping Shen
Natural products derived from bacterial sources have long been pivotal in the discovery of drug leads. However, the cultivation of only about 1% of bacteria in laboratory settings has left a significant portion of biosynthetic diversity hid...
Effects of traditional Chinese medicine on treatment outcomes in severe COVID-19 patients: a single-centre study [0.03%]
中药对重症COVID-19患者治疗结果的影响：一项单中心研究
Yongjiu Xiao,Binbin Li,Chang Liu et al.
Yongjiu Xiao et al.
As the search for effective treatments for COVID-19 continues, the high mortality rate among critically ill patients in Intensive Care Units (ICU) presents a profound challenge. This study explores the potential benefits of traditional Chin...
Observational Study
Chinese journal of natural medicines. 2024 Jan;22(1):89-96. DOI:10.1016/S1875-5364(24)60565-0 2024
Discovery of proqodine A derivatives with antitumor activity targeting NAD(P)H: quinone oxidoreductase 1 and nicotinamide phosphoribosyltransferase [0.03%]
具有抗肿瘤活性的proqodine A衍生物的发现，针对NAD(P)H：醌氧化还原酶1和烟酰胺磷酸核糖转移酶
Jiangzhou Song,Guiqing Zou,Zhou Zhao et al.
Jiangzhou Song et al.
NAD(P)H: quinone oxidoreductase 1 (NQO1) is a flavin protease highly expressed in various cancer cells. NQO1 catalyzes a futile redox cycle in substrates, leading to substantial reactive oxygen species (ROS) production. This ROS generation ...
Potassium dehydroandrographolide succinate regulates the MyD88/CDH13 signaling pathway to enhance vascular injury-induced pathological vascular remodeling [0.03%]
钾脱氢穿心莲内酯琥珀酸盐通过调节MyD88/CDH13信号通路增强血管损伤所致的病理血管重建
Qiru Guo,Jiali Li,Zheng Wang et al.
Qiru Guo et al.
Pathological vascular remodeling is a hallmark of various vascular diseases. Previous research has established the significance of andrographolide in maintaining gastric vascular homeostasis and its pivotal role in modulating endothelial ba...
Artemisia argyi extract subfraction exerts an antifungal effect against dermatophytes by disrupting mitochondrial morphology and function [0.03%]
黄艾提取物亚级分通过破坏曲霉菌的线粒体形态和功能而产生抗真菌效果
Le Chen,Yunyun Zhu,Chaowei Guo et al.
Le Chen et al.
Artemisia argyi (A. argyi), a plant with a longstanding history as a raw material for traditional medicine and functional diets in Asia, has been used traditionally to bathe and soak feet for its disinfectant and itch-relieving properties. ...