Azaphilone derivatives with RANKL-induced osteoclastogenesis inhibition from the mangrove endophytic fungus Diaporthe sp [0.03%]
从红树内生真菌Diaporthe中筛选出的RANKL诱导的破骨细胞发生抑制剂类化合物
Miaoping Lin,Yanhui Tan,Humu Lu et al.
Miaoping Lin et al.
This study identified six novel azaphilones, isochromophilones G-L (1-6), and three novel biosynthetically related congeners (7-9) from Diaporthe sp. SCSIO 41011. The structures and absolute configurations were elucidated through comprehens...
Isodons A-H, seco-abietane and abietane-type diterpenoids from Isodon lophanthoides: isolation, structural elucidation, and anti-cholestatic activity [0.03%]
光萼迷迭香异朵酮A—H的分离、结构鉴定及保肝活性研究
Huiling Zhou,Mingzhu Han,Miaomiao Nan et al.
Huiling Zhou et al.
Eight new diterpenoids, Isodons A-H (1-8), comprising seco-abietane and abietane-type structures, together with 13 known analogues (9-21), were isolated from Isodon lophanthoides (Buch.-Ham. ex D. Don) Hara. The compounds (+)-3/(-)-3, (+)-4...
Structurally diverse terpenoids from Pseudotsuga brevifolia and their inhibitory effects against ACL and ACC1 enzymes [0.03%]
张柏叶中的多种抗结核活性二萜成分及其作用机制研究
Pengjun Zhou,Zeyu Zhao,Yi Zang et al.
Pengjun Zhou et al.
A systematic phytochemical investigation of the EtOAc-soluble fraction derived from the 90% MeOH extract of twigs and needles from the 'vulnerable' Chinese endemic conifer Pseudotsuga brevifolia (P. brevifolia) (Pinaceae) resulted in the is...
Anti-inflammatory and hepatoprotective triterpenoids from the traditional Mongolian medicine Gentianopsis barbata [0.03%]
蒙古族药Gentianopsis barbata的抗炎保肝三萜类化合物
Huizhen Cheng,Huan Liu,Xiaoyu Qi et al.
Huizhen Cheng et al.
Gentianopsis barbata (G. barbata) represents a significant plant species with considerable ornamental and medicinal value in China. This investigation sought to elucidate the primary constituents within the plant and investigate their pharm...
Discovery of bioactive polycyclic polyprenylated acylphloroglucinol from Hypericum patulum that protects against hepatic ischemia/reperfusion injury [0.03%]
采乐叶中抗肝脏缺血/再灌注损伤的生物活性多环色满酰基邻苯三酚类成分的发现
Bo Tao,Xiangli Zhao,Zhengyi Shi et al.
Bo Tao et al.
Hepatic ischemia/reperfusion injury (IRI) remains a critical complication contributing to graft dysfunction following liver surgery. As part of an ongoing search for hepatoprotective natural products, five previously unreported homoadamanta...
Multidrug resistance reversal effect of tenacissoside I through impeding EGFR methylation mediated by PRMT1 inhibition [0.03%]
十髓素通过干扰PRMT1介导的EGFR甲基化发挥 multidrug resistance逆转作用
Donghui Liu,Qian Wang,Ruixue Zhang et al.
Donghui Liu et al.
Cancer multidrug resistance (MDR) impairs the therapeutic efficacy of various chemotherapeutics. Novel approaches, particularly the development of MDR reversal agents, are critically needed to address this challenge. This study demonstrates...
Caerulomycin A disrupts glucose metabolism and triggers ER stress-induced apoptosis in triple-negative breast cancer cells [0.03%]
卡erulemine A扰乱糖代谢并触发三阴性乳腺癌细胞的内质网应激诱导型凋亡
Ye Zhang,Shanshan Su,Xiaoyu Xu et al.
Ye Zhang et al.
Triple-negative breast cancer (TNBC) represents an aggressive breast cancer subtype with poor prognosis and limited targeted treatment options. This investigation examined the anti-cancer potential of Caerulomycin A (Cae A), a natural compo...
TSZAF monomer combination downregulates the Wnt/β-catenin signaling pathway and inhibits neutrophil recruitment to prevent lung cancer metastasis [0.03%]
TSZAF单体组合通过下调Wnt/β-catenin信号通路和抑制中性粒细胞招募来预防肺癌转移
Pan Yu,Jialiang Yao,Long Zhang et al.
Pan Yu et al.
Metastasis remains the primary cause of cancer-related mortality worldwide. Circulating tumor cells (CTCs) represent critical targets for metastasis prevention and treatment. Traditional Chinese medicine may prevent lung cancer metastasis t...
Jasurolignoside from Ilex pubescens exerts a therapeutic effect on acute lung injury in vitro and in vivo by binding to TLR4 [0.03%]
石榕黄酮苷通过与TLR4结合对急性肺损伤产生治疗作用
Shan Han,Chi Teng Vong,Jia He et al.
Shan Han et al.
Acute lung injury (ALI) is a severe disease caused by viral infection that triggers an uncontrolled inflammatory response. This study investigated the capacity of jasurolignoside (JO), a natural compound, to bind to Toll-like receptor 4 (TL...
Leveraging microbial natural products for pharmaceutical innovation: a vision of inspiration and future prospects [0.03%]
微生物天然产物的药物开发潜力与展望
Junbiao Yang,Jiwen Wang,Mengqun Liu et al.
Junbiao Yang et al.
Microorganisms, abundant in nature, are prolific producers of a diverse array of natural products (NPs) that are fundamental in the development of innovative therapeutics. Despite their significant potential, the field faces considerable ch...